High-Throughput Doppler Toolbox for Preclinical Drug Development

SLAS Technology - Tập 15 - Trang 287-296 - 2010
Karim Azer1, Michael C. Desiderio1, Christopher Tong2, Michelle Bunzel3, Barry R. Campbell3, Diane Shevell4, Matthew Walker3
1Department of Applied Computer Science and Mathematics, Merck & Co. Inc, Rahway, NJ
2Biometrics Research, Merck & Co. Inc, Rahway, NJ
3Department of Imaging Research, Merck & Co. Inc, Rahway, NJ
4Department of Immunology, Merck & Co. Inc, Rahway, NJ

Tóm tắt

Quantification of hemodynamics may be invaluable in a drug development setting. However, one of the challenges in the application of imaging technologies for compound screening purposes is the large volume of data in a short amount of time. This article focuses on methods developed for large-scale hemodynamic quantification, as measured from high-frequency Doppler ultrasound in rodents. An integrative semiautomated method for processing Doppler ultrasound images is described and validated. In the context of experimental biology, this toolbox allows for a comprehensive hemodynamic evaluation of in vivo physiology as the result of medical intervention, thus enabling rapid compound screening in preclinical drug development.

Tài liệu tham khảo

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SLAS Technology

Tập 15

287-296

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