High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution

Journal of Cellular Biochemistry - Tập 118 Số 12 - Trang 4317-4322 - 2017
Seyed‐Amir Tabatabaeizadeh1, Amir Avan2,3, Afsane Bahrami2, Ezzat Khodashenas4, Habibollah Esmaily5, Gordon A. Ferns6, Mojtaba Fattahi Abdizadeh7, Majid Ghayour‐Mobarhan2,3
1Faculty of Medicine Department of Clinical Nutrition Mashhad University of Medical Sciences Mashhad Iran
2Faculty of Medicine Department of Modern Sciences and Technologies Mashhad University of Medical Sciences Mashhad Iran
3Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Department of Pediatrics, School of Medicine, Mashhad University of Medical sciences, Mashhad, Iran
5Departments of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
6Brighton & Sussex Medical School Division of Medical Education Falmer Brighton Sussex BN1 9PH United Kingdom
7Faculty of Medicine Department of Microbiology Sabzevar University of Medical Sciences Sabzevar Iran

Tóm tắt

ABSTRACTThe prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of vitamin D supplementation on serum C‐Reactive Protein (CRP) level and Neutrophil‐to‐lymphocyte ratio (NLR) distribution in a large cohort of adolescent girls. A total of 580 adolescent girls were recruited follow by evaluation of CRP and hematological parameters before and after supplementation with vitamin D supplements as 9 of 50000 IU cholecalciferol capsules for 9 weeks taken at weekly intervals. At baseline, serum hs‐CRP level was 0.9 (95%CI: 0.5–1.8), while this value after intervention was reduced to 0.8 (95%CI: 0.3–1.6; P = 0.007). Similar results were also detected for NLR (e.g., NLR level was 1.66 ± 0.72 and 1.53 ± 0.67, P = 0.002, before and after therapy with compliance rate of >95.2%). Moreover, we found an association between hs‐CRP and BMI, triglyceride, white blood cell count, and lymphocytes. Interestingly we observed a significant reduction in neutrophil count and CRP level after high dose vitamin D supplementation. Our findings showed that the high dose supplementation of vitamin D affects measures of systemic inflammation: reductions in High Sensitivity C‐Reactive Protein level and Neutrophil‐to‐lymphocyte ratio (NLR) distribution. J. Cell. Biochem. 118: 4317–4322, 2017. © 2017 Wiley Periodicals, Inc.

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Journal of Cellular Biochemistry

Tập 118 Số 12

4317-4322

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