Hibernoma – two patients with a rare lipoid soft-tissue tumour
Tóm tắt
Hibernomas are rare benign soft-tissue tumours arising from brown fat tissue. Although imaging characteristics are not specific certain imaging features, common locations and patient demographics may suggest hibernoma as a differential diagnosis. We report on two 48-year-old male patients with hibernoma. The tumour presented with local swelling of the inguinal region in the first patient and was an incidental imaging finding in the second patient. Imaging included magnetic resonance imaging in both patients and computed tomography as well as 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in the second patient. In both cases histological diagnosis was initially based on excisional and needle core biopsy, respectively. Complete surgical resection confirmed the diagnosis of hibernoma thereafter. In soft tissue tumours with fatty components hibernoma may be included into the differential diagnosis. Because of the risk of sampling errors in hibernoma-like tissue components of myxoid and well-differentiated liposarcoma, complete resection is mandatory. This article also reviews the current imaging literature of hibernomas.
Tài liệu tham khảo
Anderson SE, Schwab C, Stauffer E, Banic A, Steinbach LS. Hibernoma: imaging characteristics of a rare benign soft tissue tumor. Skeletal Radiol. 2001;30:590–5.
Liu W, Bui MM, Cheong D, Caracciolog JT. Hibernoma: comparing imaging appearance with more commonly encountered benign or low-grade lipomatous neoplasms. Skeletal Radiol. 2013;42:1073–8.
Murphey MD, Carroll JF, Flemming DJ, Pope TL, Gannon FH, Kransdorf MJ. From the archives of the AFIP: benign musculoskeletal lipomatous lesions. Radiographics. 2004;24:1433–66.
Merkel H. On a pseudolipoma of the breast. Beitr Pathol Anat. 1906;39:152–7.
Gery L. In discussion of MF Bonnel’s paper. Bull Mem Soc Anat (Paris). 1914;89:111–2.
Miettinen MM, Fanburg-Smith JC, Mandahl N. Hibernoma. In: Fletscher CDM, Unni KK, Mertens F, editors. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; 2002. p. 19–46.
Furlong MA, Fanburg-Smith J, Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol. 2001;25:809–14.
Mertens F, Rydholm A, Brosjö O, Willén H, Mitelman F, Mandahl N. Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Canver. 1994;58:503–5.
Mrózek K, Karakousis CP, Bloomfield CD. Band 11q13 is nonrandomly rearranged in hibernomas. Genes Chrom Cancer. 1994;9:145–7.
Papathanassiou ZG, Alberghini M, Taieb S, Errani C, Picci P, Vanel D. Imaging of hibernomas: a retrospective study on twelve cases. Clin Sarcoma Res. 2011;1(3):1–11.
Hardes J, Scheil-Bertram S, Hartwig E, Gebert C, Gosheger G, Schulte M. Sonographic findings of hibernomas. A report of two cases. J Clin Ultrasound. 2005;33:298–301.
Bonar SF, Watson G, Gragnaniello C, Seex K, Magnussen J, Earwaker J. Intraosseous hibernoma: characterization of five cases and literature review. Skeletal Radiol. 2014;43:939–46.
Dursun M, Agayev A, Bakir B, Ozger H, Eralp L, Sirvanci M, et al. CT and MR characteristics of hibernoma: six cases. Clin Imaging. 2008;32:42–7.
Atilla S, Eilenberg SS, Brown JJ. Hibernoma: MRI appearance of a rare tumor. Magn Reson Imaging. 1995;13:335–7.
Chatterton BE, Mensforth D, Coventry BJ, Cohen P. Hibernoma: intense uptake seen on Tc-99 m tetrofosmin and FDG positron emission tomographic scanning. Clin Nucl Med. 2002;27:369–70.
Schmidt F, Cathomas R, Stallmach T, Putora PM, Mueller J. Have you ever heard of hibernoma? A rare but important pitfall in FDG-PET/CT. Nuklearmedizin. 2010;49:N71–3.
Smith S, Teruya-Feldstein J, Caravelli JF, Yeung HW. False-positive findings on 18 F-FDG PET/CT: differentiation of hibernoma and malignant fatty tumor on the basis of fluctuating standardized uptake values. Am J Roentgenol. 2008;190:1091–6.
Enterline HT, Lowry LD, Richman AV. Does malignant hibernoma exist? Am J Surg Pathol. 1979;3:265–71.
Lele SM, Chundru S, Chaljub G, Adegboyega P, Haque AK. Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med. 2002;126:975–8.
Lee JC, Gupta A, Saifuddin A, Flanagan A, Skinner JA, Briggs TWR, et al. Hibernoma: MRI features in eight consecutive cases. Clin Radiol. 2006;61:1029–34.
Gaskin CM, Helms CA. Lipomas, lipoma variants, and well-differentiated liposarcomas (atypical lipomas): results of MRI evaluations of 126 consecutive fatty masses. Am J Roentgenol. 2004;182:733–9.