Heterochromatin interactions

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Translocations, fusion genes, and acute leukemia. EMBO Reports, [http://embo-reports.oupjournals.org/] Berkeley Drosophila genome project, [http://www.fruitfly.org/] The HP1 chromo shadow domain binds a consensus peptide pentamer. The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.