Stanley J. Sarnoff1, Eugene Braunwald1, G. H. Welch1, Robert B. Case1, W. N. Stainsby1, R Macrúz1
1From the Laboratory of Cardiovascular Physiology, National Heart Institute, Bethesda, Maryland
Tóm tắt
The hemodynamic determinants of myocardial oxygen utilization were ascertained in the isolated, metabolically supported, nonfailing canine heart. The primary determinant was found to be the total tension developed by the myocardium as indicated by the area beneath the systolic pressure curve (Tension-Time Index). The significance of these findings for the understanding of the low efficiency of the failing heart and the consequently increased importance of Laplace's law are discussed.
