Hemocompatibility evaluation of poly(1,8‐octanediol citrate) blend polyethersulfone membranes

Journal of Biomedical Materials Research - Part A - Tập 105 Số 5 - Trang 1510-1520 - 2017
Muhamad Zulhilmi Zailani1, Ahmad Fauzi Ismail1, Siti Hamimah Sheikh Abdul Kadir2, Mohd Hafiz Dzarfan Othman1, Pei Sean Goh1, Hasrinah Hasbullah1, Mohd Sohaimi Abdullah1, Be Cheer Ng1, Fatmawati Kamal2
1Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Skudai, Johor, 81310 Malaysia
2Faculty of Medicine, Institute of Medical Molecular and Biotechnology (IMMB), Universiti Teknologi MARA (UiTM), Sungai Buloh, Selangor, 47000 Malaysia

Tóm tắt

AbstractIn this study, poly (1,8‐octanediol citrate) (POC) was used to modify polyethersulfone (PES)‐based membrane to enhance its hemocompatibility. Different compositions of POC (0–3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase‐inversion technique. The prepared membranes were characterized using attenuated total reflectance‐Fourier transform infrared (ATR‐FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic‐force microscopy (AFM), contact angle, Zeta‐potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection. The hemocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), and thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+absorption on membrane. Results showed that by increasing POC concentration, FBG adsorption was reduced, less platelets adhesion, prolonged APTT and PT, lower TAT, C5a and C3a activation and absorb more Ca2+ion. These results indicated that modification of PES with POC has rendered improved hemocompatibility properties for potential application in the field of blood purification, especially in hemodialysis. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1510–1520, 2017.

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Thông tin xuất bản

Journal of Biomedical Materials Research - Part A

Tập 105 Số 5

1510-1520

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