Helix‐bundle membrane protein fold templates

Protein Science - Tập 8 Số 12 - Trang 2711-2719 - 1999
James U. Bowie1
1Department of Chemistry and Biochemistry and DOE Laboratory of Structural Biology and Molecular Medicine, UCLA, 405 Hilgard Avenue, Los Angeles, California 90095–1570

Tóm tắt

AbstractIn the fold recognition approach to structure prediction, a sequence is tested for compatibility with an already known fold. For membrane proteins, however, few folds have been determined experimentally. Here the feasibility of computing the vast majority of likely membrane protein folds is tested. The results indicate that conformation space can be effectively sampled for small numbers of helices. The vast majority of potential monomeric membrane protein structures can be represented by about 30‐folds for three helices, but increases exponentially to about 1, 500, 000 folds for seven helices. The generated folds could serve as templates for fold recognition or as starting points for conformational searches that are well distributed throughout conformation space.

Từ khóa


Tài liệu tham khảo

10.1038/nsb0295-154

10.1002/(SICI)1097-0134(199611)26:3<257::AID-PROT2>3.0.CO;2-B

10.1002/(SICI)1097-0134(199708)28:4<465::AID-PROT1>3.0.CO;2-9

10.1006/jmbi.1997.1279

10.1016/S0959-440X(05)80118-6

10.1126/science.1853201

10.1002/pro.5560070121

10.1002/prot.340050106

10.1038/357543a0

10.1016/0022-2836(81)90341-7

10.1002/prot.340020209

10.1038/285378a0

10.1096/fasebj.6.15.1464373

10.1006/jmbi.1994.0097

10.1146/annurev.bb.15.060186.001541

10.1096/fasebj.10.1.8566533

10.1016/0022-2836(92)90693-E

10.1002/(SICI)1097-0134(19990601)35:4<408::AID-PROT4>3.0.CO;2-A

10.1006/jmbi.1996.0328

10.1073/pnas.89.7.2536

10.1038/358086a0

10.1038/5794

10.1016/S0968-0004(97)01078-5

10.1038/4878

10.1038/5891

10.1126/science.277.5332.1676

10.1126/science.2667138

10.1002/prot.340090107

10.1089/cmb.1997.4.217

Sternberg M, 1982, A combinatorial approach to the prediction of the tertiary fold of globular proteins, Biochem Soc Trans, 10, 299, 10.1042/bst0100299

10.1002/prot.340180309

10.1002/pro.5560070901

10.1002/pro.5560070420

10.1006/jmbi.1998.2282

10.1038/33612

Thông tin
Thông tin xuất bản

Protein Science

Tập 8 Số 12

2711-2719

Thông tin tác giả