Chất điều chỉnh đầu carboxyl làm tăng độ nhạy của tế bào với quá trình apoptosis qua protein sốc nhiệt 70

Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA: PKB and the mitochondria: AKTing on apoptosis. Cell Signal. 2008, 20 (1): 21-30. Dummler B, Hemmings BA: Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans. 2007, 35 (Pt 2): 231-235. Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA: Protein kinases, from B to C. Biochem Soc Trans. 2007, 35 (Pt 5): 1013-1017. Lawlor MA, Alessi DR: PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?. J Cell Sci. 2001, 114 (Pt 16): 2903-2910. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 1996, 15 (23): 6541-6551. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005, 307 (5712): 1098-1101. Feng J, Park J, Cron P, Hess D, Hemmings BA: Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem. 2004, 279 (39): 41189-41196. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA, Barford D: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell. 2002, 9 (6): 1227-1240. Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D: Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol. 2002, 9 (12): 940-944. Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA: Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science. 2001, 294 (5541): 374-380. Chae KS, Martin-Caraballo M, Anderson M, Dryer SE: Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons. J Neurophysiol. 2005, 93 (3): 1174-1182. Hwang SK, Kwon JT, Park SJ, Chang SH, Lee ES, Chung YS, Beck GR, Lee KH, Piao L, Park J: Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice. Gene Ther. 2007, 14 (24): 1721-1730. Knobbe CB, Reifenberger J, Blaschke B, Reifenberger G: Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. J Natl Cancer Inst. 2004, 96 (6): 483-486. Ryan MT, Hoogenraad NJ: Mitochondrial-nuclear communications. Annu Rev Biochem. 2007, 76: 701-722. Mihara K, Omura T: Cytoplasmic chaperones in precursor targeting to mitochondria: the role of MSF and hsp 70. Trends Cell Biol. 1996, 6 (3): 104-108. Young JC, Hoogenraad NJ, Hartl FU: Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell. 2003, 112 (1): 41-50. Parcellier A, Tintignac LA, Zhuravleva E, Cron P, Schenk S, Bozulic L, Hemmings BA: Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. Cell Signal. 2009, 21 (4): 639-650. Carr SA, Huddleston MJ, Annan RS: Selective detection and sequencing of phosphopeptides at the femtomole level by mass spectrometry. Anal Biochem. 1996, 239 (2): 180-192. Papayannopoulos IA: The Interpretation of collosion-induced dissociation tandem mass spectra of peptides. Mass Spectrometry Reviews. 1995, 14: 49-73. Nakai K, Horton P: PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem Sci. 1999, 24 (1): 34-36. Emanuelsson O, Nielsen H, Brunak S, von Heijne G: Predicting subcellular localization of proteins based on their N-terminal amino acid sequence. J Mol Biol. 2000, 300 (4): 1005-1016. Claros MG, Vincens P: Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur J Biochem. 1996, 241 (3): 779-786. Neupert W, Herrmann JM: Translocation of proteins into mitochondria. Annu Rev Biochem. 2007, 76: 723-749. Beere HM: Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE. 2001, 2001 (93): RE1- Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR: Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol. 2000, 2 (8): 469-475. Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES: Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000, 2 (8): 476-483. Zhang Y, Chan DC: New insights into mitochondrial fusion. FEBS Lett. 2007, 581 (11): 2168-2173. Jin S, DiPaola RS, Mathew R, White E: Metabolic catastrophe as a means to cancer cell death. J Cell Sci. 2007, 120 (Pt 3): 379-383. Fayard E, Tintignac LA, Baudry A, Hemmings BA: Protein kinase B/Akt at a glance. J Cell Sci. 2005, 118 (Pt 24): 5675-5678. Brazil DP, Yang ZZ, Hemmings BA: Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci. 2004, 29 (5): 233-242. Hanada M, Feng J, Hemmings BA: Structure, regulation and function of PKB/AKT – a major therapeutic target. Biochim Biophys Acta. 2004, 1697 (1–2): 3-16. Sasaki K, Sato M, Umezawa Y: Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells. J Biol Chem. 2003, 278 (33): 30945-30951. Gutierrez-Barrera AM, Menter DG, Abbruzzese JL, Reddy SA: Establishment of three-dimensional cultures of human pancreatic duct epithelial cells. Biochem Biophys Res Commun. 2007, 358 (3): 698-703. Braun HP, Schmitz UK: The mitochondrial processing peptidase. Int J Biochem Cell Biol. 1997, 29 (8–9): 1043-1045. Gakh O, Cavadini P, Isaya G: Mitochondrial processing peptidases. Biochim Biophys Acta. 2002, 1592 (1): 63-77. Arretz M, Schneider H, Guiard B, Brunner M, Neupert W: Characterization of the mitochondrial processing peptidase of Neurospora crassa. J Biol Chem. 1994, 269 (7): 4959-4967. Nett JH, Denke E, Trumpower BL: Two-step processing is not essential for the import and assembly of functionally active iron-sulfur protein into the cytochrome bc1 complex in Saccharomyces cerevisiae. J Biol Chem. 1997, 272 (4): 2212-2217. Xanthoudakis S, Nicholson DW: Heat-shock proteins as death determinants. Nat Cell Biol. 2000, 2 (9): E163-165. Miyawaki T, Ofengeim D, Noh KM, Latuszek-Barrantes A, Hemmings BA, Follenzi A, Zukin RS: The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci. 2009, 12 (5): 618-626. Hwang SK, Lim HT, Minai-Tehrani A, Lee ES, Park J, Park SB, Beck GR, Cho MH: Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice. Am J Respir Crit Care Med. 2009, 179 (12): 1131-1140. Lieber A, He CY, Kirillova I, Kay MA: Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol. 1996, 70 (12): 8944-8960. Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D, Zhang-Sun G, Fantus IG, Ng JB, Hall DA, Lum BS: Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem. 1994, 269 (6): 4596-4604. Park J, Hill MM, Hess D, Brazil DP, Hofsteenge J, Hemmings BA: Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J Biol Chem. 2001, 276 (40): 37459-37471. Duclos B, Marcandier S, Cozzone AJ: Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis. Methods Enzymol. 1991, 201: 10-21.