Heart Retransplantation: Candidacy, Outcomes, and Management

Current Transplantation Reports - Tập 7 - Trang 12-17 - 2019
Maya H. Barghash1,2, Sean P. Pinney1,2
1Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, USA
2The Mount Sinai Hospital, New York, USA

Tóm tắt

To describe the incidence and epidemiology of heart retransplantation in adults and children and to review the risk factors associated with adverse outcome following retransplantation to help guide recipient selection. Heart retransplantation is associated with inferior short-term and long-term survival when compared with primary heart transplantation and its use remains controversial although less so in the pediatric heart transplant population. In the most recent era of heart transplantation, patients retransplanted for CAV, greater than 1 year from their primary transplant, and who are not in critical condition have improved survival compared with other retransplant recipients. Survival with retransplantation can approach that of primary transplantation when patients are appropriately selected. More research is needed regarding the optimal timing for retransplantation and the optimal management for patients after retransplantation.

Tài liệu tham khảo

Khush KK, et al. for the International Society for Heart and Lung Transplantation. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation (ISHLT): thirty-fifth Adult Heart and Lung Transplantation Report – 2018; Focus Theme: Multiorgan Transplantation. JHLT. 2018;30(10):1155–68.

• Lund LH et al. for the International Society of Heart and Lung Transplantation. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report – 2014; focus theme: Retransplantation. JHLT 2014; 33(10): 996-1008. This ISHLT report from the international registry focused on providing data on adult heart retransplantation.

Srivastava R, Keck BM, Bennett LE, Hosenpud JD. The results of cardiac retransplantation: an analysis of the joint international society for heart and lung transplantation / united network for organ sharing (UNOS) thoracic registry. Transplantation. 2000, 70(4):606–12.

Costanzo MR, Naftel DC, Pritzker MR, Heilman JK, Boehmer JP, Brozena SC, et al. Heart transplant coronary artery disease detected by coronary angiography: a multiinstitutional study of preoperative donor and recipient risk factors. Cardiac transplant research database. J Heart Lung Transplant. 1998;17:744–75.

Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, et al. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy – 2010. J Heart Lung Transplant. 2010;29:717–27.

Belli E, Moreno JCL, Hosenpud J, Rawal B, Landolfo K. Preoperative risk factors predict survival following cardiac retransplantation: analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg. 2014;147:1972–7.

Johnson MR, Aaronson KD, Canter CE, Kirklin JK, Mancini DM, Mehra MR, et al. Heart retransplantation. Am J Transplant. 2007;7:2075–81.

Magee JC, Barr ML, Basadonna GP, Johnson MR, Mahadevan S, McBride MA, et al. Repeat organ transplantation in the United States, 1996-2005. Am J Transplant. 2007;7(2):1424–33.

Shuhaiber JH, Kim JB, Hur K, Gibbons RD, Nemeh HW, Schwartz JP, et al. Comparison of survival in primary and repeat heart transplantation from 1987 through 2004 in the United States. Ann Thorac Surg. 2007;83:2135–41.

• Khan MS, Mery CM, Zafar F, Adachi I, Heinle JS, Cabrera AG, et al. Is mechanically bridging patients with a failing cardiac graft to retransplantation an effective therapy? Analysis of the United Network of Organ Sharing database. J Heart Lung Transplant. 2012;31:1192–8 Only study focusing on mechanically bridged heart retransplant recipients and found that mechanically bridged retransplant patients performed more than one year after index heart transplant had similar outcomes to primary heart transplant.

Alturi P, Hiesinger W, Gorman RC, Pochettino A, Jessup M, Acker MA, et al. Cardiac retransplantation is an efficacious therapy for primary cardiac allograft failure. J Cardiothorac Surg. 2008;3(26):1–5.

Radovancevic B, McGiffin DC, Kobashigawa KA, Cintron GB, Mullen GM, Pitts DE, et al. Naftel DC, and the Cardiac Transplant Research Database Group at the University of Alabama at Birmingham. J Heart Lung Transplant. 2003;22:862–8.

Savla J, Lin KY, Pradhan M, Ruebner RL, Rogers RS, Haskins SS, et al. Heart retransplant recipients have better survival with concurrent kidney transplant than with heart retransplant alone. J Am Heart Assoc. 2015;4:e002435. https://doi.org/10.1161/JAHA.115.002435.

Tsao L, Uriel N, Leitz K, Naka Y, Mancini D. Higher rate of comborbidities after cardiac retransplantation contributes to decreased survival. J Heart Lung Transplant. 2009;28(10):1072–4.

Johnson SR, Cherikh WS, Kauffman HM, Pavlakis M, Hanto DW. Retransplantation after post-transplant lymphoproliferative disorders: an OPTN/UNOS database analysis. Am J Transplant. 2006;6:2743–9.

Karras A, Thervet E, Le Meur Y, Baudet-Bonneville V, Kessler M, Legendre C. Successful renal retransplantation after post-transplant lymphoproliferative disease. Am J Transplant. 2004;4:1904–9.

Conway J, Manlhiot C, Kirk R, Edwards LB, McCrindle BW, Dipchand AI. Mortality and morbidity after retransplantation after primary heart transplant in childhood: an analysis from the registry of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2014;33:241–51.

Bock MJ, Nguyen K, Malerba S, Harrison K, Bagiella E, Gelb BD, et al. Pediatric cardiac retransplantation: waitlist mortality stratified by age and era. J Heart Lung Transplant. 2015;34:530–7.

Mahle WT, Vincent RN, Kanter KR. Cardiac retransplantation in childhood: analysis of data from the United Network for Organ Sharing. J Thorac Cardiovasc Surg. 2005;130:542–6.

Thông tin
Thông tin xuất bản

Current Transplantation Reports

Tập 7

12-17

Thông tin tác giả