Hair Growth Promotion Activity and Its Mechanism ofPolygonum multiflorum

Evidence-based Complementary and Alternative Medicine - Tập 2015 - Trang 1-10 - 2015
Yunfei Li1, Mingnuan Han1, Pei Lin1, Yanran He1, Jie Yu1, Ronghua Zhao1
1Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China

Tóm tắt

Polygonum multiflorumRadix (PMR) has long history in hair growth promotion and hair coloring in clinical applications. However, several crucial problems in its clinic usage and mechanisms are still unsolved or lack scientific evidences. In this research, C57BL/6J mice were used to investigate hair growth promotion activity and possible mechanism of PMR andPolygonum multiflorumRadix Preparata (PMRP). Hair growth promotion activities were investigated by hair length, hair covered skin ratio, the number of follicles, and hair color. Regulation effects of several cytokines involved in the hair growth procedure were tested, such as fibroblast growth factor (FGF-7), Sonic Hedgehog (SHH),β-catenin, insulin-like growth factor-1 (IGF-1), and hepatocyte growth factor (HGF). Oral PMR groups had higher hair covered skin ratio (100 ± 0.00%) than oral PMRP groups (48%~88%). However, topical usage of PMRP had about 90% hair covered skin ratio. Both oral administration of PMR and topically given PMRP showed hair growth promotion activities. PMR was considered to be more suitable for oral administration, while PMRP showed greater effects in external use. The hair growth promotion effect of oral PMR was most probably mediated by the expression of FGF-7, while topical PMRP promoted hair growth by the stimulation of SHH expression.

Từ khóa


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Evidence-based Complementary and Alternative Medicine

Tập 2015

1-10

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