HPLC method for simultaneous determination of clobazam and N‐desmethylclobazam in human serum, rat serum and rat brain homogenates

Biomedical Chromatography - Tập 3 Số 2 - Trang 79-81 - 1989
Wieslaw R. Gaźik1, Jerzy Podleśany1, Marian Filipek1
1Laboratory Diagnostic Department, Memorial Hospital, Child Health Centre, Al. Dzieci Polskich 20, 04‐736 Warsaw, Poland

Tóm tắt

AbstractA method for simultaneous determination of clobazam (CBZ) and its active metabolite N‐desmethylclobazam (DCBZ) in various biological samples by RP‐HPLC with UV detection is described. The determination of both CBZ and DCBZ is performed without derivatization. The internal standard is diazepam. The method is rapid and simple with sensitivity limits of 10 ng/mL for both CBZ and DCBZ and is suitable for routine analysis as well as for animal studies.

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Tài liệu tham khảo

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Thông tin xuất bản

Biomedical Chromatography

Tập 3 Số 2

79-81

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