HOW DO FISH OILS AFFECT VASCULAR FUNCTION?

Clinical and Experimental Pharmacology and Physiology - Tập 22 Số 2 - Trang 71-81 - 1995
Jaye P.F. Chin1, Anthony M. Dart
1Alfred and Baker Medical Unit, Alfred Hospital and Baker Medical Research Institute, Prahran, Victoria, Australia

Tóm tắt

SUMMARY1. This is a review on the mechanisms by which fish oils affect vascular function and how such changes contribute to their documented cardioprotective effects.2. Evidence that fish oils depress vascular responses to contractile agents will be examined. It is concluded that this effect of fish oils is mediated predominantly by alterations in prostanoid profile.3. Effects of fish oils on arterial relaxation are discussed with particular emphasis on endothelium dependent relaxation. It is suggested that the functional impairment of endothelium dependent relaxation documented in a number of cardiovascular disease states can be reversed by dietary fish oils.4. In addition, possible effects of fish oils on growth factors, inositol trisphosphate and lipid metabolism, the sympathetic nervous system, rheological and membrane properties and inducible nitric oxide are reviewed.

Từ khóa


Tài liệu tham khảo

Abeywardena M. Y., 1991, Differential effects of fish oil on myocardial prostaglandin I2 and thromboxane A2 production, American Journal of Physiology, 260, H379

10.1038/327237a0

Bayorh M. A., 1989, Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system, Research Communications in Chemical Pathology and Pharmacology, 66, 355

10.1111/j.1365-2796.1989.tb01443.x

10.1111/j.1476-5381.1990.tb14673.x

10.1016/0952-3278(93)90003-F

Busse R., 1993, Signal transduction in endothelium dependent vasodilatation, European Heart Journal, 14, 2

10.1067/mva.1988.avs0070108

10.1161/01.HYP.21.1.22

10.1097/00004872-199311000-00010

10.1111/j.1476-5381.1994.tb13111.x

10.1111/j.1440-1681.1994.tb02442.x

10.1016/0140-6736(92)92621-L

10.1111/j.1440-1681.1992.tb00435.x

Cobiac L., 1991, Lipid, lipoprotein, and hemostatic effects offish vs fish oil n‐3 fatty acids in mildly hyperlipidemic males, American Journal of Clinical Nutrition, 53, 1210, 10.1093/ajcn/53.5.1210

Dart A. M., 1993, Effects of dietary supplementation with n‐3 polyunsaturated fatty acids on sympathetic and haemodynamic responses to stress in man, Nutrition, Metabolism and Cardiovascular Diseases, 3, 105

10.1016/0021-9150(89)90019-1

10.1161/01.CIR.82.2.428

Dinarello C. A., 1987, Current concepts: lymphokines, New England Journal of Medicine, 320, 265

Drexler H., 1991, Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolaemia, Hypertension, 19, 1190

Du X‐J, 1993, Lack of modulation by dietary unsaturated fats on sympathetic neurotransmission in rat hearts, American Journal of Physiology, 265, H886

10.1016/S0140-6736(78)91505-2

Ellis E. F., 1990, Effect of fish oil n‐3 fatty acids on cerebral microcirculation, American Journal of Physiology, 258, H1780

10.1056/NEJM198902023200501

10.1097/00005344-199210000-00009

10.1038/307165a0

10.1016/0735-1097(93)90357-7

Forstermann U., 1993, Isoforms of nitric oxide synthase: Functions in the cardiovascular system, European Heart Journal, 14, 10

10.1126/science.3393911

10.1038/288373a0

Galli C., 1981, Prostaglandins and Cardiovascular Disease

10.1001/archinte.153.13.1595

10.1126/science.6994228

10.1172/JCI115011

10.1084/jem.166.1.235

Hallaq H. A., 1992, Stabilization of cardiac arrhythmias by n‐3 PUFA. Third International Congress on Essential Fatty Acids and Eicosanoids, Adelaide, South Australia, Convenors R. Gibson and A. Sinclair., 54

10.1161/01.CIR.87.3.1017

10.1172/JCI113276

10.1016/0021-9150(89)90196-2

10.1016/S0140-6736(82)92841-0

10.1016/0140-6736(93)91981-Q

10.1016/0952-3278(91)90194-A

10.1016/0021-9150(91)90196-A

10.1136/bmj.297.6642.180

10.1097/00004872-199107000-00009

10.1016/0021-9150(90)90095-Z

10.1007/BF00504869

10.1161/01.STR.19.4.476

10.1016/0002-9149(92)90773-R

10.1016/0021-9150(90)90068-T

10.1007/BF00194308

10.1056/NEJM198604103141501

10.1016/S0140-6736(81)90373-1

10.1016/0022-2828(92)90365-7

10.1016/0140-6736(93)90634-S

Lewis T. V., 1993, Effects of human lipoproteins on vascular function, Clinical and Experimental Pharmacology and Physiology, 42

10.1016/0167-4889(89)90109-2

10.1161/01.CIR.67.3.504

10.1161/01.CIR.88.2.523

10.1161/01.ATV.12.6.691

10.1038/345161a0

10.1146/annurev.nu.10.070190.001053

10.1172/JCI113905

10.1111/j.1476-5381.1987.tb11367.x

Reibel D. K., 1988, Effects of dietary fish oil on cardiac responsiveness to adrenoceptor stimulation, American Journal of Physiology, 254, H494

10.1016/S0140-6736(89)90370-X

10.1111/j.1365-2796.1989.tb01442.x

Schini V. B., 1993, Role of the L‐arginine‐nitric oxide pathway in vascular smooth muscle, European Heart Journal, 14, 16

10.1159/000158996

10.1161/01.CIR.76.4.898

10.1161/01.CIR.78.6.1421

10.1016/0021-9150(83)90181-8

10.1007/BF00381515

10.1016/S0140-6736(89)91013-1

10.1016/S0022-2828(86)80940-3

Vekshtein V. I., 1989, Fish oil improves endothelium‐dependent relaxation in patients with coronary artery disease, Circulation, 80, 11

10.1073/pnas.83.19.7311

10.1007/BF01907066

10.1111/j.1476-5381.1991.tb12289.x

10.1111/j.1476-5381.1992.tb14352.x

Yoshimura T., 1987, Effects of highly purified eicosapentaenoic acid on plasma beta thromboglobulin level and vascular reactivity to angiotensin II, Artery, 14, 295

Thông tin
Thông tin xuất bản

Clinical and Experimental Pharmacology and Physiology

Tập 22 Số 2

71-81

Thông tin tác giả