HOTAIR: a key regulator in gynecologic cancers

Cancer Cell International - Tập 17 - Trang 1-6 - 2017
Jing Li1, Jing Wang2, Yan Zhong3, Ruixia Guo4, Danxia Chu4, Haifeng Qiu4, Zhongfu Yuan4
1Department of Oncology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University, Yantai, China
3Department of Gynecological Oncology, Linyi Tumor Hospital, Linyi, China
4Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Tóm tắt

Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown. In this review, we summarize the recent findings on the roles of HOTAIR in gynecologic cancers.

Tài liệu tham khảo

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