HCV‐specific CD27− CD28− memory T cells are depleted in hepatitis C virus and Schistosoma mansoni co‐infection

Immunology - Tập 110 Số 4 - Trang 513-518 - 2003
Mohamed F. El‐Refaei1, Nabila El-Sheikh2, Karim Kamal3, Huyen Cao1
1California Department of Health Services, Richmond, CA, USA
2Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt, and
3US Naval Medical Research Unit #3 (NAMRU‐3), Cairo, Egypt

Tóm tắt

SummaryFactors that influence the generation and maintenance of memory CD8+ T cells are not fully understood. The homeostasis of memory T cells is highly dynamic and tightly regulated by various stimuli, including cytokines and antigen–major histocompatibility complex ligands. We characterized the hepatitis C virus (HCV)‐specific CD8+ T‐cell responses in a cohort of HCV‐infected individuals with or without Schistosoma mansoni co‐infection from Egypt. We observed a significantly decreased CD27− CD28− (late differentiated) memory T‐cell population in the HCV co‐infected individuals compared to those with HCV infection alone. In contrast, there was no significant difference in the CD27+ CD28+ (early differentiated) memory T cells between the two groups. Analysis of human cytomegalovirus‐specific CD8+ T‐cell responses in the same individuals failed to reveal a similar pattern of altered memory T‐cell differentiation. Thus, S. mansoni co‐infection targets a specific subset of memory CD8+ T cells in HCV infection.

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Immunology

Tập 110 Số 4

513-518

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