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Điều Trị Virus Viêm Gan C Trong Các Bệnh Nhân Mắc Bệnh Xơ Gan Không Bù Đắp
Tóm tắt
Bài báo này sẽ xem xét điều trị virus viêm gan C (HCV) bằng các thuốc kháng virus tác động trực tiếp ở các nhóm dân cư đặc biệt. Những bệnh nhân mắc xơ gan không bù đắp có sự khác biệt sinh lý so với những bệnh nhân không mắc xơ gan hoặc mắc xơ gan bù đắp, và do đó cần có thêm các cân nhắc trong điều trị. Thảo luận thêm sẽ tập trung vào các nhóm dân cư độc đáo khác trong điều trị HCV, bao gồm những người mắc bệnh thận giai đoạn cuối, đồng nhiễm HIV hoặc virus viêm gan B, và ung thư tế bào gan. Bệnh nhân mắc xơ gan không bù đắp không đủ điều kiện sử dụng một số thuốc kháng virus tác động trực tiếp do nguy cơ làm xấu đi tình trạng bệnh và tử vong. Nhóm dân cư này cũng khá phức tạp, vì việc ghép gan cũng cần được xem xét, và việc điều trị HCV trước khi ghép có thể tạo ra những hệ quả không mong muốn trong quá trình ghép. Được khuyến nghị rằng các bệnh nhân xơ gan không bù đắp nên điều trị HCV cùng với một trung tâm ghép gan. Các thuốc kháng virus tác động trực tiếp có hiệu quả cao và được dung nạp tốt, và đã đơn giản hóa việc điều trị HCV. Tuy nhiên, những bệnh nhân như bệnh nhân xơ gan không bù đắp, đồng nhiễm virus, bệnh thận giai đoạn cuối, và ung thư tế bào gan là những trường hợp phức tạp hơn và yêu cầu thêm các xét đoán trong điều trị.
Từ khóa
#HCV #virus viêm gan C #điều trị #thuốc kháng virus tác động trực tiếp #xơ gan không bù đắpTài liệu tham khảo
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