Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Tóm tắt
The intestinal tract of mammals is colonized by a large number of microorganisms including trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous microorganisms have co‐evolved with the host in a symbiotic relationship. In addition to metabolic benefits, symbiotic bacteria provide the host with several functions that promote immune homeostasis, immune responses, and protection against pathogen colonization. The ability of symbiotic bacteria to inhibit pathogen colonization is mediated via several mechanisms including direct killing, competition for limited nutrients, and enhancement of immune responses. Pathogens have evolved strategies to promote their replication in the presence of the gut microbiota. Perturbation of the gut microbiota structure by environmental and genetic factors increases the risk of pathogen infection, promotes the overgrowth of harmful pathobionts, and the development of inflammatory disease. Understanding the interaction of the microbiota with pathogens and the immune system will provide critical insight into the pathogenesis of disease and the development of strategies to prevent and treat inflammatory disease.
Từ khóa
Tài liệu tham khảo
Sweeney NJ, 1996, The Escherichia coli K‐12 gntP gene allows E. coli F‐18 to occupy a distinct nutritional niche in the streptomycin‐treated mouse large intestine, Infect Immun, 64, 3497, 10.1128/iai.64.9.3497-3503.1996
Desai MS, 2016, A dietary fiber‐deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility, Cell, 167, e1321
Arike L, 2017, Intestinal Muc2 mucin O‐glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases, Glycobiology, 27, 318
Fiedler K, 2013, MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen, Am J Blood Res, 3, 124
Shimada S, 1999, Generation of polymeric immunoglobulin receptor‐deficient mouse with marked reduction of secretory IgA, J Immunol, 163, 5367, 10.4049/jimmunol.163.10.5367
Prantera C, 2012, Rifaximin‐extended intestinal release induces remission in patients with moderately active Crohn's disease, Gastroenterology, 142, e474
Dianda L, 1997, T cell receptor‐alpha beta‐deficient mice fail to develop colitis in the absence of a microbial environment, Am J Pathol, 150, 91