Guillain–Barré syndrome associated with SARS‐CoV‐2 infection. A systematic review

European Journal of Neurology - Tập 27 Số 11 - Trang 2361-2370 - 2020
Paolo De Sanctis1,2, Pietro Emiliano Doneddu3,2, Leandro L. Souza Viganó4, Carlo Selmi5, Eduardo Nobile‐Orazio6,3
1Department of Neurosurgery Humanitas Clinical and Research Institute – IRCCS Rozzano (MI) Italy
2These authors contributed equally to the review.
3Department of Neurology, Neuromuscular and Neuroimmunology Service Humanitas Clinical and Research Institute – IRCCS Rozzano (MI) Italy
4Department of General Surgery Humanitas Clinical and Research Institute – IRCCS Rozzano (MI) Italy
5Department of Rheumatology and Clinical Immunology Humanitas Clinical and Research Institute – IRCCS Rozzano (MI) Italy
6Department of Medical Biotechnology and Translational Medicine, Milan University, Milan, Italy

Tóm tắt

Guillain‐Barré syndrome (GBS) incidence can increase during outbreaks of infectious illnesses. A few cases of GBS associated with coronavirus disease 2019 (COVID‐19) infection have been reported. The aim was to identify specific clinical features of GBS associated with COVID‐19. PubMed, Embase and Cochrane were searched from 1 November 2019 to 17 May 2020 and included all papers with full text in English, Spanish, French or Italian, reporting original data of patients with GBS and COVID‐19. Data were extracted according to a predefined protocol. A total of 18 patients reported in 14 papers were included in this review. All the patients were symptomatic for COVID‐19, with cough and fever as the most frequently reported symptoms. The interval between the onset of symptoms of COVID‐19 and the first symptoms of GBS ranged from −8 to 24 days (mean 9 days; median 10 days). Most of the patients had a typical GBS clinical form predominantly with a demyelinating electrophysiological subtype. Mechanical ventilation was necessary in eight (44%) patients. Two (11%) patients died. Published cases of GBS associated with COVID‐19 report a sensorimotor, predominantly demyelinating GBS with a typical clinical presentation. Clinical features and disease course seem similar to those observed in GBS related to other etiologies. These results should be interpreted with caution since only 18 cases have been heterogeneously reported so far.

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European Journal of Neurology

Tập 27 Số 11

2361-2370

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