Growth Differentiation Factor 15: A Canary in a Coal Mine?

Kannel, 1961, Factors of risk in the development of coronary heart disease—six year follow-up experience. The Framingham Study, Ann Intern Med, 55, 33, 10.7326/0003-4819-55-1-33

Hlatky, 2009, Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association, Circulation, 119, 2408, 10.1161/CIRCULATIONAHA.109.192278

Morrow, 2007, Benchmarks for the assessment of novel cardiovascular biomarkers, Circulation, 115, 949, 10.1161/CIRCULATIONAHA.106.683110

Rohatgi, 2012, Association of growth differentiation factor-15 with coronary atherosclerosis and mortality in a young, multiethnic population: observations from the Dallas Heart Study, Clin Chem, 58, 172, 10.1373/clinchem.2011.171926

Daniels, 2011, Growth-differentiation factor-15 is a robust, independent predictor of 11-year mortality risk in community-dwelling older adults: the Rancho Bernardo Study, Circulation, 123, 2101, 10.1161/CIRCULATIONAHA.110.979740

Lind, 2009, Growth-differentiation factor-15 is an independent marker of cardiovascular dysfunction and disease in the elderly: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, Eur Heart J, 30, 2346, 10.1093/eurheartj/ehp261

Bootcov, 1997, MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily, Proc Natl Acad Sci U S A, 94, 11514, 10.1073/pnas.94.21.11514

Xu, 2006, GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation, Circ Res, 98, 342, 10.1161/01.RES.0000202804.84885.d0

Kempf, 2006, The transforming growth factor-β superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury, Circ Res, 98, 351, 10.1161/01.RES.0000202805.73038.48

Kempf, 2011, GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice, Nat Med, 17, 581, 10.1038/nm.2354

Taddei, 2010, Growth differentiation factor-15 and cardiovascular dysfunction and disease: malefactor or innocent bystander?, Eur Heart J, 31, 1168, 10.1093/eurheartj/ehq077

Xu, 2011, Growth differentiation factor 15 in cardiovascular diseases: from bench to bedside, Biomarkers, 16, 466, 10.3109/1354750X.2011.580006

Mimeault, 2010, Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer, J Cell Physiol, 224, 626, 10.1002/jcp.22196

Wilson, 2011, Prediction of cardiovascular disease events, Cardiol Clin, 29, 1, 10.1016/j.ccl.2010.10.004

Pencina, 2008, Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond, Stat Med, 27, 157, 10.1002/sim.2929

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, 2001, Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), JAMA, 285, 2486, 10.1001/jama.285.19.2486

Pencina, 2011, Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers, Stat Med, 30, 11, 10.1002/sim.4085