Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

Swerdlow SH et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. IARC, Lyon

Kluin PM et al (2008) B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. In: Swerdlow SH et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, IARC, pp 265–266

Jaffe ES et al (2008) B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin Lymphoma. In: Swerdlow SH et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, IARC, pp 267–268

Macpherson N et al (1999) Small noncleaved, non-Burkitt’s (Burkitt-like) lymphoma: cytogenetics predict outcome and reflect clinical presentation. J Clin Oncol 17(5):1558–1567

Kanungo A et al (2006) Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol 19(1):25–33

Rosenwald A et al (2003) Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 198(6):851–862

Savage KJ et al (2003) The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 102(12):3871–3879

Traverse-Glehen A et al (2005) Mediastinal gray zone lymphoma: the missing link between classic Hodgkin’s lymphoma and mediastinal large B-cell lymphoma. Am J Surg Pathol 29(11):1411–1421

Fan Z et al (2003) Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol 27(10):1346–1356

Boudova L et al (2003) Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma. Blood 102(10):3753–3758

Nakamura S, Jaffe ES, Swerdlow SH (2008) EBV positive diffuse large B-cell lymphoma of the elderly. In: Swerdlow SH et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, IARC, pp 243–244

Burkitt D (1958) A sarcoma involving the jaws in African children. Br J Surg 46(197):218–223

Blum KA, Lozanski G, Byrd JC (2004) Adult Burkitt leukemia and lymphoma. Blood 104(10):3009–3020

Magrath I (1990) The pathogenesis of Burkitt’s lymphoma. Adv Cancer Res 55:133–270

Dave SS et al (2006) Molecular diagnosis of Burkitt’s lymphoma. N Engl J Med 354(23):2431–2442

Hummel M et al (2006) A biologic definition of Burkitt’s lymphoma from transcriptional and genomic profiling. N Engl J Med 354(23):2419–2430

Salaverria I et al (2008) Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt’s lymphoma. Haematologica 93(9):1327–1334

Boerma EG et al (2009) Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of today’s knowledge. Leukemia 23(2):225–234

Haralambieva E et al (2004) Interphase fluorescence in situ hybridization for detection of 8q24/MYC breakpoints on routine histologic sections: validation in Burkitt lymphomas from three geographic regions. Genes Chromosomes Cancer 40(1):10–18

Haralambieva E et al (2005) Clinical, immunophenotypic, and genetic analysis of adult lymphomas with morphologic features of Burkitt lymphoma. Am J Surg Pathol 29(8):1086–1094

Klapper W et al (2008) Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL). Leukemia 22(12):2226–2229

Savage KJ et al (2009) MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood 114(17):3533–3537

Mead GM et al (2008) A prospective clinicopathologic study of dose-modified CODOX-M/IVAC in patients with sporadic Burkitt lymphoma defined using cytogenetic and immunophenotypic criteria (MRC/NCRI LY10 trial). Blood 112(6):2248–2260

Sevilla DW et al (2007) Clinicopathologic findings in high-grade B-cell lymphomas with typical Burkitt morphologic features but lacking the MYC translocation. Am J Clin Pathol 128(6):981–991

Mossafa H et al (2006) Non-Hodgkin’s lymphomas with Burkitt-like cells are associated with c-Myc amplification and poor prognosis. Leuk Lymphoma 47(9):1885–1893

Leucci E et al (2008) MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J Pathol 216(4):440–450

Johnson NA et al (2009) Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survival. Blood 114(11):2273–2279

Le Gouill S et al (2007) The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14;18) and 8q24/c-MYC rearrangement. Haematologica 92(10):1335–1342

Lin P, Medeiros LJ (2007) High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis. Haematologica 92(10):1297–1301

Kramer MH et al (1991) De novo acute B-cell leukemia with translocation t(14;18): an entity with a poor prognosis. Leukemia 5(6):473–478

Lichtenstein AK et al (1980) Primary mediastinal lymphoma in adults. Am J Med 68(4):509–514

Higgins JP, Warnke RA (1999) CD30 expression is common in mediastinal large B-cell lymphoma. Am J Clin Pathol 112(2):241–247

Moller P et al (1986) Primary mediastinal clear cell lymphoma of B-cell type. Virchows Arch A Pathol Anat Histopathol 409(1):79–92

Paulli M et al (1999) Mediastinal B-cell lymphoma: a study of its histomorphologic spectrum based on 109 cases. Hum Pathol 30(2):178–187

Pileri SA et al (2003) Pathobiology of primary mediastinal B-cell lymphoma. Leuk Lymphoma 44(Suppl 3):S21–S26

Moller P et al (1987) Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation. Blood 69(4):1087–1095

Pileri SA et al (2003) Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulins. Am J Pathol 162(1):243–253

Rodig SJ et al (2007) Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphoma. Am J Surg Pathol 31(1):106–112

Calaminici M et al (2004) CD23 expression in mediastinal large B-cell lymphomas. Histopathology 45(6):619–624

Salama ME et al (2009) The value of CD23 expression as an additional marker in distinguishing mediastinal (thymic) large B-cell lymphoma from Hodgkin lymphoma. Int J Surg Pathol (in press)

Bea S et al (2005) Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood 106(9):3183–3190

Joos S et al (2000) Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30+ Hodgkin cells. Cancer Res 60(3):549–552

Joos S et al (1996) Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL gene. Blood 87(4):1571–1578

Kimm LR et al (2007) Frequent occurrence of deletions in primary mediastinal B-cell lymphoma. Genes Chromosomes Cancer 46(12):1090–1097

Copie-Bergman C et al (1999) The MAL gene is expressed in primary mediastinal large B-cell lymphoma. Blood 94(10):3567–3575

Copie-Bergman C et al (2002) MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. Mod Pathol 15(11):1172–1180

Jaffe ES et al (1994) The interrelationship between Hodgkin’s disease and non-Hodgkin’s lymphomas. Ann Oncol 5(Suppl 1):7–11

Jaffe ES, Zarate-Osorno A, Medeiros LJ (1992) The interrelationship of Hodgkin’s disease and non-Hodgkin’s lymphomas—lessons learned from composite and sequential malignancies. Semin Diagn Pathol 9(4):297–303

Perrone T, Frizzera G, Rosai J (1986) Mediastinal diffuse large-cell lymphoma with sclerosis. A clinicopathologic study of 60 cases. Am J Surg Pathol 10(3):176–191

Poppema S et al (2005) Report: workshop on mediastinal grey zone lymphoma. Eur J Haematol Suppl 66:45–52

Rudiger T et al (1998) Workshop report on Hodgkin’s disease and related diseases (‘grey zone’ lymphoma). Ann Oncol 9(Suppl 5):S31–S38

Hsi ED et al (2006) MAL is expressed in a subset of Hodgkin lymphoma and identifies a population of patients with poor prognosis. Am J Clin Pathol 125(5):776–782

Seitz V et al (2000) Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease. Blood 95(10):3020–3024

Rodriguez-Justo M et al (2008) Cyclin D1-positive diffuse large B-cell lymphoma. Histopathology 52(7):900–903

Ehinger M et al (2008) A subset of CD5- diffuse large B-cell lymphomas expresses nuclear cyclin D1 with aberrations at the CCND1 locus. Am J Clin Pathol 129(4):630–638

Lai R et al (2000) Sinusoidal CD30-positive large B-cell lymphoma: a morphologic mimic of anaplastic large cell lymphoma. Mod Pathol 13(3):223–228

Carbone A et al (1997) BCL-6 protein expression in human peripheral T-cell neoplasms is restricted to CD30+ anaplastic large-cell lymphomas. Blood 90(6):2445–2450

Barry TS et al (2003) Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol 27(12):1513–1522

Saffer H et al (2002) Clusterin expression in malignant lymphomas: a survey of 266 cases. Mod Pathol 15(11):1221–1226

Wellmann A et al (2000) Detection of differentially expressed genes in lymphomas using cDNA arrays: identification of clusterin as a new diagnostic marker for anaplastic large-cell lymphomas. Blood 96(2):398–404

Chandra P et al (2009) Clusterin expression correlates with stage and presence of large cells in mycosis fungoides. Am J Clin Pathol 131(4):511–515

Franke S et al (2002) Comparative genomic hybridization pattern distinguishes T-cell/histiocyte-rich B-cell lymphoma from nodular lymphocyte predominance Hodgkin’s lymphoma. Am J Pathol 161(5):1861–1867

Prakash S et al (2006) IgD positive L&H cells identify a unique subset of nodular lymphocyte predominant Hodgkin lymphoma. Am J Surg Pathol 30(5):585–592

Nam-Cha SH et al (2008) PD-1, a follicular T-cell marker useful for recognizing nodular lymphocyte-predominant Hodgkin lymphoma. Am J Surg Pathol 32(8):1252–1257

Poppema S et al (2008) Nodular lymphocyte predominant Hodgkin lymphoma. In: Swerdlow SH et al (eds) B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin Lymphoma. Lyon, IARC, pp 323–325

Anagnostopoulos I et al (2000) European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes. Blood 96(5):1889–1899

Dogan A et al (2003) Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis. Am J Surg Pathol 27(7):903–911

McBride JA et al (1996) T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin’s disease. Am J Surg Pathol 20(2):193–201

Lim MS et al (2002) T-cell/histiocyte-rich large B-cell lymphoma: a heterogeneous entity with derivation from germinal center B cells. Am J Surg Pathol 26(11):1458–1466

von Wasielewski R et al (1997) Classical Hodgkin’s disease. Clinical impact of the immunophenotype. Am J Pathol 151(4):1123–1130

Oyama T et al (2003) Senile EBV+ B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol 27(1):16–26

Shimoyama Y et al (2008) Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease. Cancer Sci 99(6):1085–1091

Asano N et al (2009) Age-related Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classic Hodgkin lymphoma in elderly patients. Blood 113(12):2629–2636

Park S et al (2007) The impact of Epstein-Barr virus status on clinical outcome in diffuse large B-cell lymphoma. Blood 110(3):972–978

Wong HH, Wang J (2009) Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly. Leuk Lymphoma 50(3):335–340

Chang CC et al (2004) Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol 28(4):464–470

Garcia JF et al (2005) Large B-cell lymphoma with Hodgkin’s features. Histopathology 47(1):101–110

Gibson SE, Hsi ED (2009) Epstein-Barr virus-positive B-cell lymphoma of the elderly at a United States tertiary medical center: an uncommon aggressive lymphoma with a nongerminal center B-cell phenotype. Hum Pathol 40(5):653–661

Chuah KL et al (2009) Plasmablastic lymphoma affecting the lung and bone marrow with CD10 expression and t(8;14)(q24;q32) translocation. Int J Surg Pathol 17(2):163–166

Yotsumoto M et al (2009) CD20-negative CD138-positive leukemic large cell lymphoma with plasmablastic differentiation with an IgH/MYC translocation in an HIV-positive patient. Intern Med 48(7):559–562

Montes-Moreno S et al (2008) Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas. Blood 111(1):351–358

Diehl SA et al (2008) STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol 180(7):4805–4815

Teruya-Feldstein J et al (2004) CD20-negative large-cell lymphoma with plasmablastic features: a clinically heterogenous spectrum in both HIV-positive and -negative patients. Ann Oncol 15(11):1673–1679

Jenkins C et al (2005) Human-immunodeficiency-virus-negative, human-herpes-virus-8-negative abdominal cavity primary effusion lymphoma. Clin Oncol (R Coll Radiol) 17(8):636–638

Tanaka S et al (2001) HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype. Pathol Int 51(4):293–300

Ohshima K et al (2002) Chromosomal and comparative genomic analyses of HHV-8-negative primary effusion lymphoma in five HIV-negative Japanese patients. Leuk Lymphoma 43(3):595–601

Liebow AA, Carrington CR, Friedman PJ (1972) Lymphomatoid granulomatosis. Hum Pathol 3(4):457–558

Pfistershammer K et al (2009) Methotrexate-induced primary cutaneous diffuse large B-cell lymphoma with an ‘angiocentric’ histological morphology. Clin Exp Dermatol (in press)

Dodero A et al (2009) Haploidentical stem cell transplantation after a reduced-intensity conditioning regimen for the treatment of advanced hematologic malignancies: posttransplantation CD8-depleted donor lymphocyte infusions contribute to improve T-cell recovery. Blood 113(19):4771–4779

Ricci F et al (2009) Fludarabine in the treatment of chronic lymphocytic leukemia: a review. Ther Clin Risk Manag 5(1):187–207

Abruzzo LV et al (2002) Epstein-Barr virus-positive B-cell lymphoproliferative disorders arising in immunodeficient patients previously treated with fludarabine for low-grade B-cell neoplasms. Am J Surg Pathol 26(5):630–636

de Leval L et al (2004) Distinct clonal origin in two cases of Hodgkin’s lymphoma variant of Richter’s syndrome associated With EBV infection. Am J Surg Pathol 28(5):679–686

Fong D et al (2005) Hodgkin’s disease variant of Richter’s syndrome in chronic lymphocytic leukaemia patients previously treated with fludarabine. Br J Haematol 129(2):199–205

Thornton PD et al (2005) Richter’s transformation of chronic lymphocytic leukemia. The possible role of fludarabine and the Epstein-Barr virus in its pathogenesis. Leuk Res 29(4):389–395

Mao Z et al (2007) IgVH mutational status and clonality analysis of Richter’s transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol 31(10):1605–1614

Ascani S et al (1997) Pyothorax-associated lymphoma: description of the first two cases detected in Italy. Ann Oncol 8(11):1133–1138

Petitjean B et al (2002) Pyothorax-associated lymphoma: a peculiar clinicopathologic entity derived from B cells at late stage of differentiation and with occasional aberrant dual B- and T-cell phenotype. Am J Surg Pathol 26(6):724–732

Childs CC, Parham DM, Berard CW (1987) Infectious mononucleosis. The spectrum of morphologic changes simulating lymphoma in lymph nodes and tonsils. Am J Surg Pathol 11(2):122–132

Lustberg MB, Aras O, Meisenberg BR (2008) FDG PET/CT findings in acute adult mononucleosis mimicking malignant lymphoma. Eur J Haematol 81(2):154–156

Macsween KF, Crawford DH (2003) Epstein-Barr virus—recent advances. Lancet Infect Dis 3(3):131–140

Otteman LA et al (1985) Infectious mononucleosis mimicking a B cell immunoblastic lymphoma associated with an abnormality in regulatory T cells. Am J Med 78(5):885–890

Vrsalovic MM et al (2004) T- and B-cell clonality and frequency of human herpes viruses-6, -8 and Epstein Barr virus in angioimmunoblastic T-cell lymphoma. Hematol Oncol 22(4):169–177

Zhou Y et al (2007) Angioimmunoblastic T-cell lymphoma: histological progression associates with EBV and HHV6B viral load. Br J Haematol 138(1):44–53