Granny trips down: is she carrying the big bad wolf?

van Geel BM, Assies J, Wanders RJ, Barth PG (1997) X linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy. J Neurol Neurosurg Psychiatry 63:4–14 Jangouk P, Zackowski KM, Naidu S, Raymond GV (2012) Adrenoleukodystrophy in female heterozygotes: underrecognized and undertreated. Mol Genet Metab 105:180–185 Salsano E, Tabano S, Sirchia SM, Colapietro P, Castellotti B, Gellera C, Rimoldi M, Pensato V, Mariotti C, Pareyson D, Miozzo M, Uziel G (2012) Preferential expression of mutant ABCD1 allele is common in adrenoleukodystrophy female carriers but unrelated to clinical symptoms. Orphanet J Rare Dis 7:10 Schmidt S, Träber F, Block W, Keller E, Pohl C, von Oertzen J, Schild H, Schlegel U, Klockgether T (2001) Phenotype assignment in symptomatic female carriers of X-linked adrenoleukodystrophy. J Neurol 248:36–44 Jung HH, Wimplinger I, Jung S, Landau K, Gal A, Heppner FL (2007) Phenotypes of female adrenoleukodystrophy. Neurology 68:960–961 Marino S, De Luca M, Dotti MT, Stromillo ML, Formichi P, Galluzzi P, Mondelli M, Bramanti P, Federico A, De Stefano N (2007) Prominent brain axonal damage and functional reorganization in “pure” adrenomyeloneuropathy. Neurology 69:1261–1269 O’Brien TJ, Gates PG, Byrne E (1996) Symptomatic female heterozygotes for adrenoleukodystrophy: a report of two unrelated cases and review of the literature. J Clin Neurosci 3:166–170 Snyder RD, King JN, Keck GM, Orrison WW (1991) MR imaging of the spinal cord in 23 subjects with ALD-AMN complex. AJNR Am J Neuroradiol 12:1095–1098 van Geel BM, Koelman JH, Barth PG, Ongerboer de Visser BW (1996) Peripheral nerve abnormalities in adrenomyeloneuropathy: a clinical and electrodiagnostic study. Neurology 46:112–118 Moser HW, Moser AB, Naidu S, Bergin A (1991) Clinical aspects of adrenoleukodystrophy and adrenomyeloneuropathy. Dev Neurosci 13:254–261