Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging

Blood Advances - Tập 2 - Trang 14-24 - 2018
T.R.L. Klei1, D.Z. de Back1, P.J. Asif1, P.J.J.H. Verkuijlen1, M. Veldthuis2, P.C. Ligthart3, J. Berghuis2, E. Clifford2, B.M. Beuger1, T.K. van den Berg1,4, R. van Zwieten1,2, W. El Nemer5, R. van Bruggen1
1Department of Blood Cell Research, Sanquin Research and Laboratory Services and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;
2Laboratory for Red Blood Cell Diagnostics, Sanquin, Amsterdam, The Netherlands;
3Serology Department, Sanquin, Amsterdam, The Netherlands;
4Department of Molecular Cell Biology, VU Medical Center, Amsterdam, The Netherlands
5Université Sorbonne Paris Cité, Université Paris Diderot, INSERM, Institut National de la Transfusion Sanguine, Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex, Paris, France

Tóm tắt

Key PointsThe Lu/BCAM adhesion molecule is gradually activated during erythrocyte aging due to loss of sialic acid on glycophorin-C. Upon activation, Lu/BCAM engages a sialic acid–dependent interaction with the extracellular matrix protein laminin-α5.

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Blood Advances

Tập 2

14-24

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