Glutamine Synthetase: Glial Localization in Brain

American Association for the Advancement of Science (AAAS) - Tập 195 Số 4284 - Trang 1356-1358 - 1977
Antonio Martinez-Hernandez1, Katherine P. Bell2, Michael D. Norenberg2
1Department of Pathology, University of Colorado Medical Center, Denver 80220
2Laboratory Service, Denver Veterans Administration Hospital, Denver 80220 and Department of Pathology, University of Colorado Medical Center

Tóm tắt

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, γ-aminobutyric acid, and ammonia metabolism in brain.

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