Glutamate Inhibits Ingestive Behaviour

Journal of Neuroendocrinology - Tập 6 Số 4 - Trang 403-408 - 1994
I. Bednar1, Minping Qian1, A. Aziz Qureshi1, Lillemor Källström2, Allan E. Johnson2, Hugo F. Carrer1, Per Södersten1
1Department of Clinical Neuroscience and Clinical Research Centre, Karolinska Institute, S-141 86 Huddinge, Sweden.
2Department of Psychiatry, Ulleråker, University of Uppsala, S-750 17 Uppsala, Sweden.

Tóm tắt

AbstractMale rats treated with reserpine were motionless and ingested only a few of ten consecutive intraoral injections of a 1 M solution of sucrose. While injection of apomorphine, a dopamine agonist, stimulated locomotion and stereotyped sniffing in reserpinized rats, it did not reactivate ingestive responses. The non‐competitive N‐methyl‐D‐aspartate receptor antagonist MK801, however, stimulated locomotion as well as ingestion suggesting involvement of glutamate in the suppressive effect of resperpine on ingestive responses. A series of experiments was therefore undertaken to investigate the possible physiological role of glutamate in feeding.For this purpose, we used Grill's intraoral intake test, in which the rat is infused intraorally with a sucrose solution and the amount ingested measured. In untreated rats, MK801 dose‐dependently facilitated ingestion of the sucrose solution and antagonized inhibition of ingestion by cholecystokinin octapeptide. Administration of cholecystokinin octapeptide or ingestion of sucrose increased the concentration of glutamate in the nucleus of the solitary tract, a brain stem relay transmitting sensory information from the gastrointestinal tract to the forebrain. MK801 was found to bind specifically to this brain area and block the elevation of glutamate and dopamine levels which occurred after treatment with cholecystokinin octapeptide in this neural site. Together these data suggest that dopamine and glutamate may interact within the nucleus of the solitary tract in controlling ingestive behaviour.

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Tài liệu tham khảo

10.1038/245323a0

10.1016/0031-9384(90)90240-5

Deutsch JA, 1990, Handbook of behavioral neurobiology, vol. 10, 151

10.1111/j.1365-2826.1991.tb00308.x

10.1111/j.1365-2826.1992.tb00224.x

10.1111/j.1365-2826.1992.tb00225.x

10.2307/1536346

10.1016/0006-8993(78)90568-1

Grill H, 1991, Handbook of behavioral neurobiology, vol. 10, 125

10.1038/363347a0

10.1016/0166-2236(93)90136-A

10.1146/annurev.pa.30.040190.000403

10.1016/0165-6147(91)90532-W

10.1016/0166-2236(92)90101-D

10.1038/1801200a0

10.1016/0166-2236(90)90108-M

10.1016/0306-4522(93)90341-C

Cooper JR, 1991, The biochemical basis of neuropharmacology, 270

10.1111/j.1365-2826.1992.tb00152.x

10.1002/cne.902730206

Grill HJ, 1988, Cholecystokinin decreases sucrose intake in chronic decerebrate rats, Am J Physiol, 254, R853

10.1007/BF01960229

10.3109/00365528509088832

10.1172/JCI111809

Liddle RA, 1986, Protein, but not amino acids, carbohydrates or fats stimulate cholecystokinin secretion in the rat, Am J Physiol, 251, G243

Mössner J, 1993, Influence of various nutrient and their mode of application on plasma cholecystokinin (CCK) bioactivity, Clin Invest, 70, 125

Mamoun H, 1994, Diet independent suppression of ingestive behaviour by cholecystokinin octapeptide and amino acids, Am J Physiol

10.1111/j.1471-4159.1993.tb13416.x

Vaquez E, 1993, Facilitation of glutamate release by a metabotropic autoreceptor, Eur J Neurosci.

Grill HJ, 1987, Feeding and drinking, 151

10.1007/BF00433091

10.1016/0014-2999(84)90567-3

10.1111/j.1365-2826.1992.tb00184.x

10.1126/science.283.5400.401

10.1002/bmc.1130050508

10.1080/10826079208016371

Subramaniam S, 1991, Quantitative autoradiographic characterization of the binding of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a,d]cyclohepten‐5,10imine([3H]MK‐801) in rat brain: regional effects of polyamines, J Pharmacol Exp Ther, 256, 811

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Journal of Neuroendocrinology

Tập 6 Số 4

403-408

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