Glucose tolerance, plasma lipoproteins and tissue lipoprotein lipase activities in body builders
Tóm tắt
Oral glucose tolerance, insulin binding to erythrocyte receptors, serum lipids, and lipoproteins, and lipoprotein lipase activities of adipose tissue and skeletal muscle were measured in nine body builders (relative body weight (RBW) 118±4%), eight weight-matched (RBW 120±5%) and seven normal-weight controls (RBW 111±3%). The body builders had 50% higher relative muscle mass of body weight (% muscle) and 50% smaller relative body fat content (% fat) than the two other groups (P<0.005). Maximal aerobic power was comparable in the three groups. In the oral glucose tolerance test (OGTT), blood glucose levels, and plasma insulin levels were lower (P<0.05) in the body builders than in weight-matched controls. Insulin binding to erythrocytes was similar in each group. On the basis of multiple linear regression analysis, 87% of the variation in plasma insulin response could be explained by body composition (% muscle and % fat) and
$$V_{O_2 \max }$$
. Plasma total cholesterol, low-density lipoprotein (LDL) cholesterol, and very low-density lipoprotein (VLDL) triglyceride concentrations were significantly lower in the body builders than in weight-matched controls. In comparison with the normal-weight group, the body builders had a lower total cholesterol level. High density lipoprotein (HDL) cholesterol, its subfractions (HDL2 and HDL3 cholesterol) and lipoprotein lipase (LPL) activities of adipose tissue and skeletal muscle were comparable in all three groups. Partial correlation analysis showed a positive relationship between plasma total triglyceride, total cholesterol and LDL cholesterol on the other hand and the % fat on the other. The results indicate that a shift in body composition from the adipose to the muscular type is associated with 1) lower glucose and insulin levels during the OGTT and 2) decrease in total and VLDL triglyceride and in total and LDL cholesterol levels but unchanged HDL cholesterol level. Thus, body builders are characterized by some metabolic features which decrease the risk of coronary heart disease. In contrast to aerobic training, body building does not influence HDL or its subfractions.
Tài liệu tham khảo
Anyan WR, Jr (1978) Adolescent medicine in Primary care. John Wiley et Sons, New York, p 137
Berg A, Keul J, Ringwald G, Deus B, Wybitul K (1980) Physical performance and serum cholesterol fractions in healthy young men. Clin Chim Acta 106: 325–330
Björntorp P, Fahlen M, Grimby G, Gustafson A, Holm J, Renström P, Schersten T (1972) Carbohydrate and lipid metabolism in middle-aged physically well-trained men. Metabolism 21: 1037–1044
Campbell DE (1965) Influence of several physical activities on serum cholesterol concentrations in young men. Lipid Res 6: 478–480
Clarkson PM, Hintermeister R, Fillyow M, Stylos L (1981) High-density lipoprotein cholesterol in young adult weight lifters, runners and untrained subjects. Human Biol 53: 251–257
Desbuquois B, Aurbach GD (1971) Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassay. J Clin Endocrinol Metab 33: 732–738
Dixon WJ (1981) BMDP Statistical software. University of California Press, Berkeley
Dufaux B, Assmann G, Hollmann W (1982) Plasma lipoproteins and physical activity: A review. Int J Sports Med 3: 123–136
Gambhir KK, Archer JA, Carter L (1977) Insulin radioreceptor assay for human erythrocytes. Clin Chem 23: 1590–1595
Glueck CJ, Tylor HL, Jacobs D, Morrison JA, Breaglehole R, Williams OD (1980) Plasma high density lipoprotein cholesterol: association with measurements of body mass. Circulation 62: 62–69
Heymsfield SB, McManus C, Smith J, Stevens V, Nixon DW (1982) Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm-muscle area. Am J Clin Nutr 36: 680–690
HyvÄrinen A, NikkilÄ EA (1962) Specific determination of blood glucose with o-toluidine. Clin Chim Acta 7: 140–143
Jelliffe EFB, Jelliffe DB (1969) The arm circumference as a public health index of protein calorie malnutrition in early childhood. J Trop Pediatr 15: 177–260
Katz LD, Glickman MG, Rapaport S, Ferrannini E, DeFronzo RA (1983) Splanchnic and peripheral disposal of glucose in man. Diabetes 32: 675–679
Kessler G, Lederer H (1965) Fluorometric measurements of triglycerides. In: Skeggs LT (ed) Automation in analytical chemistry. Mediad, New York, p 345
Krauss RM, Lindgren FT, Wood PD, Haskell WL, Albers JJ, Cheung MC (1977) Differential increases in plasma high density lipoprotein subfractions and apoliproteins (Apo-Lp) in runners. Circulation [Suppl III] 56: 4
Lehtonen A, Viikari J (1980) Serum lipids in soccer and ice-hockey players. Metabolism 29: 36–39
Lohmann D, Liebold F, Heilmann W, Senger H, Pohl A (1978) Diminished insulin response in highly trained athletes. Metabolism 27: 521–524
Lopez-S A, Stone MH, Johnson C, Bell L (1980) Effect of resistive training on serum lipids and lipoproteins of middle age sedentary men (Abstract) Am J Clin Nutr 33: 939
MacDougall JD, Sale DG, Elder GCB, Sutton JR (1982) Muscle ultrastructural characteristics of elite powerlifters and bodybuilders. Eur J Applied Physiol 48: 117–126
NikkilÄ EA, Taskinen M-R, Kekki M (1978a) Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man. Atheroclerosis 29: 497–501
NikkilÄ EA, Taskinen M-R, Rehunen S, HÄrkönen M (1978b) Lipoprotein lipase activity in adipose tissue and skeletal muscle of runners: relation to serum lipoproteins. Metabolism 27: 1661–1671
Olefsky J, Reaven GM, Farquhar JW (1974) Effects of weight reduction on obesity. Studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest 53: 64–76
Pipes TV (1979) Physiological characteristics of elite body builders. Physician Sportsmed 7: 116–122
Prince FP, Hikida RS, Hagerman FC (1976) Human muscle fiber types in power lifters, distance runners and untrained subjects. Pflügers Arch 363: 19–26
Salans LB and Wise JK (1970) Metabolic studies in obesity. Med Clin North Am 54: 1533–1542
Saltin B, åstrand P-O (1967) Maximal oxygen uptake in athletes. J Applied Physiol 23: 353–358
Schnabel A, Kindermann W (1982) Effect of maximal oxygen uptake and different forms of physical training on serum lipoproteins. Eur J Applied Physiol 48: 263–277
Solyom A (1972) Effect of androgens on serum lipids and lipoproteins. Lipids 7: 100–105
Soman VR, Koivisto VA, Deibert D, Felig P, DeFronzo RA (1979) Increased insulin sensitivity and insulin binding to monocytes after physical training. N Engl J Med 301: 1200–1204
Stern MP, Olefsky J, Farquhar JW, Reaven GM (1973) Relationship between fasting plasma lipids levels and adipose tissue morphology. Metabolism 22: 1311–1317
Taskinen M-R, NikkilÄ EA, Huttunen JK, Hilden H (1980) A micromethod for the assay of lipoprotein lipase activity in needle biopsy samples of human adipose tissue and skeletal muscle. Clin Chim Acta 104: 107–117
WHO Expert Committee on Diabetes Mellitus (1980) WHO Technical Report Series NO 646
Yki-JÄrvinen H, Koivisto VA (1983) Effects of body composition on insulin sensitivity. Diabetes 32: 965–969