Germs, genomics and global public health

The HUGO Journal - Tập 3 - Trang 5-9 - 2009
T. Pang1
1Research Policy & Cooperation, World Health Organization, Geneva 27, Switzerland

Tóm tắt

Scientific and technological advances derived from the genomics revolution have a central role to play in dealing with continuing infectious disease threats in the developing world caused by emerging and re-emerging pathogens. These techniques, coupled with increasing knowledge of host-pathogen interactions, can assist in the early identification and containment of outbreaks as well as in the development of preventive vaccination and therapeutic interventions, including the urgent need for new antibiotics. However, the effective application of genomics technologies faces key barriers and challenges which occur at three stages: from the research to the products, from the products to individual patients, and, finally, from patients to entire populations. There needs to be an emphasis on research in areas of greatest need, in facilitating the translation of research into interventions and, finally, the effective delivery of such interventions to those in greatest need. Ultimate success will depend on bringing together science, society and policy to develop effective public health implementation strategies to provide health security and health equity for all peoples.

Tài liệu tham khảo

Blacksell SD, Newton PN, Bell D et al (2006) The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue virus infection. Clin Infect Dis 42:1127–1134 Burke MA, Matlin S (eds) (2008) Monitoring Financial Flows for Health Research 2008—Prioritizing research for health equity. Global Forum for Health Research, Geneva Chirac P, Torreele E (2006) Global framework on essential health R&D. Lancet 367:1560–1561 Daar AS, Thorsteinsdottir H, Martin DK et al (2002) Top ten biotechnologies for improving health in developing countries. Nat Genet 32:229–232 Farrar J (2007) Global health science: a threat and an opportunity for collaborative clinical science. Nat Immunol 8:1277–1279 Horton R (2009) The global financial crisis: an acute threat to health. Lancet 373:355–356 Jones G, Steketee RW, Black RE et al (2003) How many child deaths can we prevent this year? Lancet 362:65–71 Jones KE, Patel NG, Levy MA et al (2008) Global trends in emerging infectious diseases. Nature 451:990–993 Katsanis SH, Javitt G, Hudson K et al (2008) A case study of personalized medicine. Science 320:53–54 Keeton K (2008) South African doctors move quickly to contain new virus. Bull WHO 86:912–913 King DA, Peckham C, Waage JK et al (2006) Infectious diseases: preparing for the future. Science 313:1392–1393 Layne SP, Monto AS, Taubenberger JK (2009) Pandemic influenza: an inconvenient mutation. Science 323:1560–1561 Leroy JL, Habicht JP, Pelto G et al (2007) Current priorities in health research funding and lack of impact on the number of child deaths per year. Am J Public Health 97:219–223 Mabey D, Peeling RW, Ustianowski A et al (2004) Diagnostics for the developing world. Nat Revs Microbiol 2:231–240 McGuire AL, Cho MK, McGuire SE et al (2007) The future of personal genomics. Science 317:1687 Moran M, Guzman J, Ropars AL et al (2009) Neglected disease research and development: how much are we really spending? PLoS Med 6:e1000030 Murray CJL, Lopez AD, Chin B et al (2006) Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918–20 pandemic: a quantitative analysis. Lancet 368:2211–2218 NIH. National Institutes of Health. NIH Challenge Grants in Health and Science Research. http://grants.nih.gov/grants/funding/challenge_award/ (Accessed on April 9, 2009) Nijnik A, Hancock REW (2009) Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections. Emerg Health Threats J 2:e1 Normile D (2008) The promise and pitfalls of clinical trials overseas. Science 322:214–216 Normile D (2009) Scientists puzzle over Ebola-Reston virus in pigs. Science 323:451 Peeling RW, Mabey D, Fitzgerald DW et al (2004) Avoiding HIV and dying of syphilis. Lancet 364:1561–1563 Peeling RW, Smith PG, Bossuyt PMM (2006) A guide for diagnostic evaluations. Nat Revs Microbiol 4:52–56 Povelones M, Waterhouse RM, Kafatos F et al (2009) Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites. Science 324:258–261 Rothwell PM (2006) Funding for practice-oriented clinical research. Lancet 368:262–266 Taubes G (2008) The bacteria fight back. Science 321:356–361 White NJ (2006) Clinical trials in tropical diseases: a politically incorrect view. Trop Med Intern Health 11:1483–1484 World Health Organization (2004) World report on knowledge for better health. WHO, Geneva World Health Organization (2006) World health statistics 2006. WHO, Geneva World Health Organization (2008) World health statistics 2008. WHO, Geneva