The HUGO Journal
SCOPUS (2009-2015)
1877-6566
1877-6558
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Clinical and pathological characteristics of Chinese patients with BRCA related breast cancer
- 2009
Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes
- 2011
Abstract Angiotensin-I-converting enzyme (ACE) is known to be associated with
human cardiovascular and psychiatric pathophysiology. We have undertaken a
global survey of the haplotypes in ACE gene to study diversity and to draw
inferences on the nature of selective forces that may be operating on this gene.
We have investigated the haplotype profiles reconstructed using polymorphisms in
the regula...
Intra-consortium data sharing in multi-national, multi-institutional genomic studies: gaps and guidance
Tập 3 - Trang 11-14 - 2009
Growing investments in health research by governments and charitable
organizations have fueled an increase in collaborative research projects between
investigators from affluent and developing countries. Current international
guidelines are silent on common intra-consortium data-sharing issues that arise
in the context of such collaborations. A lack of guidance on intra-consortium
data sharing thr...
Current status and future potential of somatic mutation testing from circulating free DNA in patients with solid tumours
Tập 4 - Trang 11-21 - 2011
Genetic alterations can determine the natural history of cancer and its
treatment response. With further advances in DNA sequencing technology, multiple
novel genetic alterations will be discovered which could be exploited as
prognostic, predictive and pharmacodynamic biomarkers in the development and use
of cancer therapeutics. As such, the importance in clinical practice of
efficient and robust ...
Translational genomics in personalized medicine – scientific challenges en route to clinical practice
Tập 6 - Trang 1-9 - 2012
In the area of omics and translational bio(medical)sciences, there is an
increasing need to integrate, normalize, analyze, store and protect genomics
data. Large datasets and scientific knowledge are rationally combined into
valuable clinical information that ultimately will benefit human healthcare and
are en route to clinical practice. Data from biomarker discovery and Next
Generation Sequencing...
27th HUGO-IABCR congress 2010: poster abstracts 5–7 October 2010, Singapore
Tập 4 - Trang 65-77 - 2011
The impact of cis-acting polymorphisms on the human phenotype
Tập 5 - Trang 13-23 - 2011
Cis-acting polymorphisms that affect gene expression are now known to be
frequent, although the extent and mechanisms by which such variation affects the
human phenotype are, as yet, only poorly understood. Key signatures of
cis-acting variation are differences in gene expression that are tightly
associated with regulatory SNPs or expression Quantitative Trait Loci (eQTL) and
an imbalance of allel...
Genetic determinants of immune-response to a polysaccharide vaccine for typhoid
Tập 3 - Trang 17-30 - 2010
Differences in immunological response among vaccine recipients are determined
both by their genetic differences and environmental factors. Knowledge of
genetic determinants of immunological response to a vaccine can be used to
design a vaccine that circumvents immunogenetic restrictions. The currently
available vaccine for typhoid is a pure polysaccharide vaccine, immune response
to which is T-cel...