Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

Lecia V. Sequist1,2, Belinda A. Waltman1, Dora Dias‐Santagata3,1, Subba R. Digumarthy4,1, Alexa B. Turke1,2, Panos Fidias1,2, Kristin Bergethon3, Alice T. Shaw1,2, Scott Gettinger5, Arjola K. Cosper2, Sara Akhavanfard3,1, Rebecca S. Heist1,2, Jennifer S. Temel1,2, James G. Christensen6, John C. Wain7,1,2, Thomas J. Lynch5, Kathy Vernovsky2, Eugene J. Mark3,1, Michael Lanuti7,1,2, A. John Iafrate3,1, Mari Mino‐Kenudson3,1, Jeffrey A. Engelman1,2
1Harvard Medical School Boston, MA 02115 USA
2Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
3Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
4Department of Radiology, Massachusetts General Hospital, Boston, MA 02114 USA
5Yale University School of Medicine and Yale Cancer Center, New Haven, CT 06520, USA.
6Translational Pharmacology, Pfizer Oncology, La Jolla, CA 92121, USA.
7Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA

Tóm tắt

Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.

Từ khóa


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