Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Tóm tắt
Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors.
Từ khóa
Tài liệu tham khảo
Guix M., Faber A. C., Wang S. E., Olivares M. G., Song Y., Qu S., Rinehart C., Seidel B., Yee D., Arteaga C. L., Engelman J. A., Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J. Clin. Invest. 118, 2609–2619 (2008).
Amann J., Kalyankrishna S., Massion P. P., Ohm J. E., Girard L., Shigematsu H., Peyton M., Juroske D., Huang Y., Stuart Salmon J., Kim Y. H., Pollack J. R., Yanagisawa K., Gazdar A., Minna J. D., Kurie J. M., Carbone D. P., Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res. 65, 226–235 (2005).
Mok T., Spigel D. R., Park K., Socinski M. A., Tung S. Y., Kim D., Borzillo G., Zhang H., O’Connell J. P., Jänne P. A., Efficacy and safety of PF-00299804 (PF299), an oral, irreversible, pan-human epidermal growth factor receptor (pan-HER) tyrosine kinase inhibitor (TKI), as first-line treatment (tx) of selected patients (pts) with advanced (adv) non-small cell lung cancer (NSCLC). J. Clin. Oncol. 28, abstract 7537 (2010).
Regales L., Gong Y., Shen R., de Stanchina E., Vivanco I., Goel A., Koutcher J. A., Spassova M., Ouerfelli O., Mellinghoff I. K., Zakowski M. F., Politi K. A., Pao W., Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J. Clin. Invest. 119, 3000–3010 (2009).
Chung J. H., Rho J. K., Xu X., Lee J. S., Yoon H. I., Lee C. T., Choi Y. J., Kim H. R., Kim C. H., Lee J. C., Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs. Lung Cancer, 10.1016/j.lungcan.2010.11.011 (2010). PubMed
Uramoto H., Iwata T., Onitsuka T., Shimokawa H., Hanagiri T., Oyama T., Epithelial–mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma. Anticancer Res. 30, 2513–2517 (2010).
Oxnard G. R., Arcila M. E., Sima C., Riely G. J., Chmielecki J., Kris M. G., Pao W., Ladanyi M., Miller V. A., Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR mutant lung cancer: Distinct natural history of patients with tumors harboring the T790M mutation. Clin. Cancer Res., 10.1158/1078-0432.CCR-10-2692 (2010). PubMed