Genotoxicity evaluation of two derived products from Allium extracts: s-propylmercaptocysteine and s-propyl mercaptoglutathione

Abad, 2021, Productivity and intestinal microbiota of laying hens, Animals, 11, 1 Abad, 2016, A rapid and simple UHPLC-ESI-MS/MS method for the screening of propyl propane thiosulfonate, a new additive for animal feed, Analythical Methods, 8, 3730, 10.1039/C6AY00219F Baltrop, 1991, 5-((3-Carboxyphenyl)-3-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)) tetrazolium, inner salt (MTS) and related analogs of 2-(4,5-dimethylthiazolyl)-2,5-diphenylterazolium bromide (MTT) reducing to purple water soluble formazan as cell-viability indicators, Bioorganic & Medicinal Chemistry Letters, 1, 611, 10.1016/S0960-894X(01)81162-8 Borkowska, 2012, Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc, European Journal of Nutrition, 51, 817, 10.1007/s00394-011-0260-x Bradford, 1976, A rapid sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, 72, 248, 10.1016/0003-2697(76)90527-3 Cascajosa-Lira, 2022, In vitro toxicity studies of bioactive organosulfur compounds from allium spp. with potential application in the agri-food industry: A review, Foods, 11, 2620, 10.3390/foods11172620 Cascajosa-Lira, 2022, Acute and subchronic 90-days toxicity assessment of propyl-propane-thiosulfinate (PTS) in rats. Food and, Chemical Toxicology, 161 Cascajosa-Lira, 2021, Simultaneous determination of Allium compounds (Propyl propane thiosulfonate and thiosulfinate) in animal feed using UPLC-MS/MS, Food and Chemical Toxicology, 157, 10.1016/j.fct.2021.112619 Cascajosa-Lira, 2020, Safety assessment of propyl-propane-thiosulfonate (PTSO): 90-days oral subchronic toxicity study in rats, Food and Chemical Toxicology, 144 Cascajosa-Lira, 2020, Mutagenicity and genotoxicity assessment of a new biopreservative product rich in Enterocin AS-48, Food and Chemical Toxicology, 146, 10.1016/j.fct.2020.111846 Cascajosa-Lira, 2021, Genotoxicity evaluation of propyl-propane-thiosulfinate (Pts) from allium genus essential oils by a combination of micronucleus and comet assays in rats, Foods, 10, 989, 10.3390/foods10050989 Catanzaro, 2022, Anticancer potential of allicin: A review, Phamacology Research, 117 Collins, 1997, UV-sensitive rodent mutant cell lines of complementation groups 6 and 8 differ phenotypically from their human counterparts, Environmental and Molecular Mutagenesis, 29, 152, 10.1002/(SICI)1098-2280(1997)29:2<152::AID-EM6>3.0.CO;2-G Cozzolino, 2021, Comparative analysis of volatile profiles and phenolic compounds of Four Southern Italian onion (Allium cepa L.) Landraces, Journal of Food Composition and Analysis, 101, 10.1016/j.jfca.2021.103990 2016, EFSA Journal, 14, 4357 2012, Food additives and nutrient sources added to food (ANS); guidance for submission for food additive evaluations, EFSA Journal, 10, 2760 2011, Scientific opinion on genotoxicity testing strategies applicable to food and feed safety as-sessment, EFSA Journal, 9, 2379 Farhat, 2021, Types of garlic and their an-ticancer and antioxidant activity: A review of the epidemiologic and experimental evidence, European Journal of Nutrition, 60, 3585, 10.1007/s00394-021-02482-7 Fujii, 2018, Changes of S-allylmercaptocysteine and γ-glutamyl-S-allylmercaptocysteine contents and their putative production mechanisms in garlic extract during the aging process, Journal of Agricultural and Food Chemistry, 66, 10506, 10.1021/acs.jafc.8b02541 Guillamón, 2018, Effect of phytochemical compounds of the genus Allium on the immune system and the inflammatory response, Ars Pharmaceutica, 59, 185 Guillamón, 2021, Beneficial effects of organosulfur compounds from allium cepa on gut health: A systematic review, Foods, 10, 10.3390/foods10081680 Guyonnet, 2000, Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation, Mutation Research/Genetic Toxicology and Environmental, 466, 17, 10.1016/S1383-5718(99)00234-X Hsu, 2006, Protective effect of s-allyl cysteine and s-propyl cysteine on acetaminophen induced hepatotoxicity in mice, Food and Chemical Toxicology, 44, 393, 10.1016/j.fct.2005.08.012 Hsu, 2004, Five cysteinecontaining compounds delay diabetic deterioration in Balb/cA mice, Journal of Nutrition, 134, 3245, 10.1093/jn/134.12.3245 Imai, 2014, Protective effect of S-allyl-l-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain, Amino Acids, 46, 385, 10.1007/s00726-013-1628-4 Kosuge, 2003, S-allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death, Neuroscience, 122, 0, 10.1016/j.neuroscience.2003.08.026 Krishnan, 2019, Green synthesized selenium nanoparticle as carrier and potent deliver-ing agent of allyl glutathione: Anticancer effect against hepatocarcinoma cell line (HepG2) through induction of cell cy-cle arrest and apoptosis, Journal of Drug Delivery Science and Technology, 53, 10.1016/j.jddst.2019.101207 Llana-Ruiz-Cabello, 2015, Acute toxicological studies of the main organosulfur compound derived from Allium sp. intended to be used in active food packaging, Food and Chemical Toxicology, 82, 1, 10.1016/j.fct.2015.04.027 Llana-Ruiz-Cabello, 2015, Cytotoxic and mutagenic in vitro assessment of two organosulfur compounds derived from onion to be used in the food industry, Food Chemistry, 166, 423, 10.1016/j.foodchem.2014.06.058 Llana-Ruiz-Cabello, 2014, Evaluation of the mutagenicity and genotoxic potential of carvacrol and thymol using the Ames Salmonella test and alkaline, Endo III- and FPG-modified comet assays with the human cell line Caco-2, Food and Chemical Toxicology, 72, 122, 10.1016/j.fct.2014.07.013 Maisanaba, 2015, In vitro genotoxicity testing of carvacrol and thymol using the micronucleus and mouse lymphoma assays, Mutation Research/Genetic Toxicology and Environmental, 784–785, 37, 10.1016/j.mrgentox.2015.05.005 Marimuthu, 2020, Protective effect of diallyl disulfide against cerulein induced acute pancreatitis and as-sociated lung injury in mice, International Immunopharmacology, 80 Martínez-Fernández, 2015, Response of the rumen archaeal and bacterial populations to anti-methanogenic organosulphur compounds in continuous-culture fermenters, FEMS Microbiology Ecology, 91, 1, 10.1093/femsec/fiv079 Medrano-Padial, 2021, In vitro assessment of the mutagenic and genotoxic potential of a pure stilbene extract, Food and Chemical Toxicology, 150, 10.1016/j.fct.2021.112065 Mellado-García, 2015, Genotoxicity assessment of propyl thiosulfinate oxide, an organosulfur compound from Allium extract, intended to food active packaging, Food and Chemical Toxicology, 86, 365, 10.1016/j.fct.2015.11.011 Mellado-García, 2017, In vitro toxicological assessment of an organosulfur compound from Allium extract: Cytotoxicity, mutagenicity and genotoxicity studies, Food and Chemical Toxicology, 99, 231, 10.1016/j.fct.2016.12.007 Mellado-García, 2016, Genotoxicity of a thiosulfonate compound derived from allium sp. intended to be used in active food packaging: In vivo comet assay and micronucleus test, Mutation Research/Genetic Toxicology and Environmental, 800–801, 1 Mong, 2012, Nuclear factor κb-dependent anti-inflammatory effects of S -allyl cysteine and S-propyl cysteine in kidney of diabetic mice, Journal of Agricultural and Food Chemistry, 60, 3158, 10.1021/jf3002685 Mylona, 2019, Influence of two garlic-derived compounds, propyl propane thiosulfonate (PTS) and propyl propane thiosulfinate (PTSO), on growth and mycotoxin production by Fusarium species, Vitro and in Stored Cereals. Toxins, 11, 495 2016, Test No. 487 2020, Vol. 4 Poojary, 2017, Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies, Journal of Food Composition and Analysis, 61, 28, 10.1016/j.jfca.2017.04.007 Puerto, 2009, Effects of dietary N-acetylcysteine on the oxidative stress induced in tilapia (oreochromis niloticus) exposed to a microcystin-producing cyanobacterial water bloom, Environmental Toxicology and Chemistry, 28, 679, 10.1897/08-520.1 Putnik, 2019, An overview of organosulfur compounds from Allium spp.: From processing and preservation to evaluation of their bioavailability, antimicrobial, and anti-inflammatory properties, Food Chemistry, 276, 680, 10.1016/j.foodchem.2018.10.068 Rabelo-Ruiz, 2021, Allium-based phytobiotic enhances egg production in laying hens through microbial composition changes in ileum and cecum, Animals, 11, 1, 10.3390/ani11020448 Rodrigues-Barreto, 2019, Genotoxicological safety assessment of puree-only edible films from onion bulb (Allium cepa L.) for use in food packaging-related applications, Journal of Food Science, 85, 201, 10.1111/1750-3841.14977 Roy, 2017, EGFR gene regulation in colorectal cancer cells by garlic phytocompounds with special emphasis on S-Allyl-L-Cysteine Sulfoxide, Interdisciplinary Sciences: Computational Life Sciences, 10, 686 Sielicka-Dudzin, 2012, Impact of JNK1, JNK2, and ligase Itch on reactive oxygen species formation and survival of prostate cancer cells treated with diallyl trisulfide, European Journal of Nutrition, 51, 573, 10.1007/s00394-011-0241-0 Thayumanavan, 2017, S-Allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency, Environmental Toxicology and Pharmacology, 58, 21, 10.1016/j.etap.2017.12.006 Tsai, 2011, s-Allyl cysteine, sethyl cysteine, and s-propyl cysteine alleviate β-amyloid, glycative, and oxidative injury in brain of mice treated by D galactose, Journal of Agricultural and Food Chemistry, 59, 6319, 10.1021/jf201160a Wu, 2011, Diallyl sulfide induces cell cycle arrest and apoptosis in HeLa human cervical cancer cells through the p53, caspase- and mitochondria-dependent pathways, International Journal of Oncology, 38, 1605 Xiao, 2018, Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway, Acta Pharmaceutica Sinica B, 8, 575, 10.1016/j.apsb.2017.10.003 Yao, 2016, Identification of glutathione and related cysteine conjugates derived from reactive metabolites of methyleugenol in rats, Chemistry & Biology, 253, 143 Zhang, 2010, Cysteine and glutathione mixed disulfide conjugates of thiosulfinates: Chemical synthesis and biological activities, Journal of Agricultural and Food Chemistry, 58, 1564, 10.1021/jf9029354 Zhang, 2014, Garlic-derived compound S-allylmercaptocysteine inhibits cell growth and induces apoptosis via the JNK and p38 pathways in human colorectal carcinoma cells, Oncology Letters, 8, 2591, 10.3892/ol.2014.2579 Zhong, 2001, Differentiation of the mechanism of micronuclei induced by cysteine and glutathione conjugates of methylenedi-p-phenyl diisocyanate from that of 4,4′-methylenedianiline, Chemistry & Biology, 497, 143