Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

PLoS Genetics - Tập 4 Số 10 - Trang e1000242
Manching Ku1,2,3, Richard P. Koche1,4,3, Esther Rheinbay5,1,3, Eric M. Mendenhall1,2,3, Mitsuhiro Endoh6, Tarjei S. Mikkelsen1,4, Aviva Presser1,7, Chad Nusbaum1, Xiaohui Xie8, S. Andrew1,3, Mazhar Adli1,2,3, Simon Kasif5, Leon M. Ptaszek9,10,11, Chad A. Cowan10,11, Eric S. Lander1,12, Haruhiko Koseki6, B Bernstein1,2,10,3
1Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America
2Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
4Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America
5Bioinformatics Program and Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
6RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama, Japan
7School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, United States of America
8Department of Computer Science, University of California Irvine, Irvine, California, United States of America
9Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
10Harvard Stem Cell Institute, Cambridge, Massachusetts, United States of America
11Stowers Medical Institute, Center for Regenerative Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America
12Whitehead Institute for Biomedical Research, MIT, Cambridge, Massachusetts, United States of America

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