Đào Huy Mạnh1, Phan Trong Lan2, Thang M. Cao1, Quang Chấn Lương3, Hang Pham1, Nhung H. P. Vu1, Nghia Van Khuu3, Thinh Viet Nguyen3, Long Thanh Nguyen1, Hieu Trung Nguyen1, Anh Hoang Nguyen1, Loan K. T. Huynh1, T. Huynh1, Quan Nguyen1, Hieu Cong Truong3, Hang Minh Nguyen4, Tung X. Trinh4, Dung T. Nguyen5, Trieu Nguyen6, Hung Thai6, Quang Duy Pham7,8, Thượng Vũ Nguyễn1
1Microbiology and Immunology Department, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam
2Directorial Board, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam
3Department for Disease Control and Prevention, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam
4General Department of Preventive Medicine, Ha Noi, Vietnam
5Ho Chi Minh City Center for Diseases Control, Ho Chi Minh City, Vietnam
6Pasteur Institute of Nha Trang, Nha Trang, Vietnam
7Planning Division, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam
8Training Center, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam
Tóm tắt
AbstractGenome‐wide analysis of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) strains is essential to better understand infectivity and virulence and to track coronavirus disease 2019 (COVID‐19) cases and outbreaks. We performed whole‐genome sequencing of 27 SARS‐CoV‐2 strains isolated between January 2020 and April 2020. A total of 54 mutations in different genomic regions was found. The D614G mutation, first detected in March 2020, was identified in 18 strains and was more likely associated with a lower cycle threshold (<25) in real‐time reverse‐transcription polymerase chain reaction diagnostic tests than the original D614 (prevalence ratio = 2.75; 95% confidence interval, 1.19–6.38). The integration of sequencing and epidemiological data suggests that SARS‐CoV‐2 transmission in both quarantine areas and in the community in Vietnam occur at the beginning of the epidemic although the country implemented strict quarantine quite early, with strict contact tracing, and testing. These findings provide insights into the nature of the epidemic, as well as shape strategies for COVID‐19 prevention and control in Vietnam.
