Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

PLoS Genetics - Tập 7 Số 3 - Trang e1001324
Elizabeth K. Speliotes1,2,3,4, Laura Crisponi5, Jun Wu6, Rubén Hernáez7,8,9, Lauren J. Kim10, Lyle J. Palmer11, Vilmundur Guðnason12,13, Guðný Eiríksdóttir12, Melissa García10, Lenore J. Launer10, Michael E. Weale14, Jeanne M. Clark7,9,15, Braxton D. Mitchell5, Alan R. Shuldiner5,16, Anna L. Gloyn2,3,11, Marta Tomás17,18, Udo Seedorf19,20, Shih‐Jen Hwang21, Joseph M. Massaro22,21, Christopher J. O’Donnell20,23,21, Dushyant V. Sahani19, Ko Willems van Dijk24, Eric J. Brunner25, Stephen M. Schwartz26,27, David S. Siscovick26, Benjamin F. Voight1, J. Jeffrey Carr28, Mary F. Feitosa6, Tamara B. Harris10, Caroline Hayward23,21, Albert Hofman12, W.H. Linda Kao7,15, Joel N. Hirschhorn1,29,11, Ingrid B. Borecki6
1Broad Institute, Cambridge, Massachusetts, United States of America
2Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America
3Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
4Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
5Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
6Division of Statistical Genomics, Department of Genetics, Washington University, Saint Louis, Missouri, United States of America
7Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
8Department of Internal Medicine, Washington Hospital Center, Washington D.C., United States of America
9Division of General Internal Medicine, The Johns Hopkins Hospital, Baltimore, Maryland, United States of America
10Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
11Divisions of Endocrinology and Genetics and Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America
12Icelandic Heart Association, Kopavogur, Iceland
13University of Iceland, Reykjavik, Iceland
14Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
15Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland, United States of America
16Geriatric Research and Education Clinical Center (GRECC), Veterans Administration Medical Center, Baltimore, Maryland, United States of America
17Ciber Epidemiología y Salud Pública, Barcelona, Spain
18Cardiovascular Epidemiology and Genetics, Institut Municipal d'Investigació Mèdica, Barcelona, Spain
19Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
20Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
21Framingham Heart Study, National Heart, Lung, and Blood Institute (NHLBI), Framingham, Massachusetts, United States of America
22Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
23Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America
24Chronic Disease Epidemiology Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland
25Pacific Biosciences, Menlo Park, California, United States of America
26Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
27Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
28Departments of Radiologic Sciences, Internal Medicine-Cardiology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
29 Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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PLoS Genetics

Tập 7 Số 3

e1001324

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