Genome Sequence of a Novel HIV-1 Circulating Recombinant Form 54_01B from Malaysia

Journal of Virology - Tập 86 Số 20 - Trang 11405-11406 - 2012
Yutaka Takebe1, Lai Yee Ong2, Adeeba Kamarulzaman2, Kok Keng Tee2
1Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
2aCentre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Tóm tắt

ABSTRACT We report here the first novel HIV-1 circulating recombinant form (CRF) 54_01B (CRF54_01B) isolated from three epidemiologically unlinked subjects of different risk groups in Malaysia. These recently sampled recombinants showed a complex genome organization composed of parental subtype B′ and CRF01_AE, with identical recombination breakpoints observed in the gag , pol , and vif genes. Such a discovery highlights the ongoing active generation and spread of intersubtype recombinants involving the subtype B′ and CRF01_AE lineages and indicates the potential of the new CRF in bridging HIV-1 transmission among different risk groups in Southeast Asia.

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Tài liệu tham khảo

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Journal of Virology

Tập 86 Số 20

11405-11406

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