Genexpressions- und Proteomanalyse – Reif für die klinische Anwendung?

Gynäkologische Endokrinologie - Tập 16 - Trang 153-159 - 2018
P. Edimiris1, A. P. Bielfeld1
1UniKiD, Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

Tóm tắt

Mit der Einführung der Genexpressionsanalyse des Endometriums eröffnen sich neue diagnostische und therapeutische Möglichkeiten für die Reproduktionsmedizin. Es ist nun möglich, anhand von Genexpressionsmustern den Zykluszeitpunkt einer Endometriumbiopsie sicher zu bestimmen. Darüber hinaus ist es gelungen, die Transkriptomsignatur eines rezeptiven Endometriums zu identifizieren. Bei wiederholtem Implantationsversagen kann darüber bei 25 % der Patientinnen ein verschobenes Implantationsfenster diagnostiziert werden. Die genomische Signatur des individuellen Endometriums im Vergleich zur etablierten „fertilen Signatur“ erlaubt den zeitlich angepassten und damit personalisierten Embryonentransfer. Ein nicht unerheblicher Teil der Patientinnen mit wiederholtem Implantationsversagen kann jedoch nach wie vor nicht adäquat behandelt werden. Pathologische Genexpressionsmuster werden als Ursache diskutiert, sind aber bisher kaum behandelbar. Womöglich können mikroRNA- und Proteomanalysen in der näheren Zukunft weitere diagnostische und therapeutische Lücken schließen.

Tài liệu tham khảo

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