Genetics and variability in opioid response

European Journal of Pain - Tập 9 Số 2 - Trang 101-104 - 2005
Ulrike M. Stamer1, Bettina Bayerer1, Frank Stüber1
1Department of Anaesthesiology and Intensive Care Medicine, Rheinische Friedrich‐Wilhelms‐Universität Bonn, Sigmund‐Freud‐Str. 25, 53105 Bonn, Germany

Tóm tắt

AbstractThe human genome project has revealed data on genomic variation which may influence the pharmacological responses. In pain therapy, the genetic background influencing the efficacy of opioid therapy is of special interest. Screening for variations in expression of drug metabolizing enzymes has been suggested as a potential tool for improving patient therapy. CYP2D6 genetic variability is supposed to be a major factor of adverse drug reaction, possibly influencing hospital stay and total costs. Further candidate genes involved in pain perception, pain processing and pain management like opioid receptors, transporters and other targets of pharmacotherapy are under investigation. Aspects of genetic differences influencing efficacy, side effects and adverse outcome of pharmacotherapy will be of importance for future pain management.

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Tài liệu tham khảo

10.1074/jbc.M006352200

10.1097/00008571-199606000-00001

10.1016/S0304-3959(98)00021-9

10.1200/JCO.2002.09.064

10.1124/mol.58.2.328

10.1001/jama.279.15.1200

10.1097/00008571-200201000-00002

10.1097/00000542-200210000-00011

10.1007/s002280050200

10.1016/S0009-9236(96)90211-8

Raffa R.B., 1993, Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol, J. Pharmacol. Exp. Ther., 267, 331

RittnerHL SteinC.Involvement of cytokines chemokines and adhesion molecules in opioid analgesia.Eur J Pain this issue in press doi:10.1016/j.ejpain.2004.05.009.

Sachse C., 1997, Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences, Am. J. Hum. Genet., 60, 284

10.1016/S0304-3959(03)00212-4

10.1126/science.134.3489.1530

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European Journal of Pain

Tập 9 Số 2

101-104

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