Genetic investigation in mesangial IgA nephropathy

Wiley - Tập 19 Số 2 - Trang 108-114 - 1982
Jean‐Claude Petit1, M. H. Gazes2, F Berthoux3, Erna van Loghem4, Jane Goguen5, J Séger6, C. Chapuis‐Chllier7, M. Marcelin1, Gerda de Lange4, Marvin R. Garovoy5, J. L. Serre8, C.P. Brizard1, Charles B. Carpenter5
1Laboratoire d'Immunologie du C.H.R.—C.T.S. Université de Saint-Etienne, France
2Institut national d'Etude Démographique. (Service du Pr A. JAOUARD), Paris, France
3Unité de Néphrologie. CHR. Université de Saint-Etienne, France
4Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, Netherlands
5Immunogenetics Laboratory, Renal Division, Brigham and Women's Hospital, Boston, U.S.A.
6Centre National de Transfusion Sanguine (Service du Pr Ch. SALMON). Paris, France
7Laboratoire Central de Biochimie B (Service du Pr R. CREYSSEL). Hopital Edouard Herriot. Université de Lyon, France
8INSERM, U. 155, Chareau de Longchamps, Paris, France

Tóm tắt

HLA—A, B. C. DR, MB, Bf, Gm, Am, Pi and Km genes (and 12 erythrocyte genetic systems) have been analyzed and correlated with clinical or biological features in 88 mesangial IgA glomerulonephritis.These data pointed out 2 gene frequency modifications: a significant MB1 specificity decrease in the total patient group and a significant Km I increase in the chronic renal failure mesangial IgA nephropathy subgroup.

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