Genetic and environmental influences on conduct disorder: symptom, domain and full‐scale analyses

Journal of Child Psychology and Psychiatry and Allied Disciplines - Tập 46 Số 6 - Trang 580-591 - 2005
Heather L. Gelhorn1, Michael C. Stallings1, Susan E. Young1, Robin P. Corley1, Soo Hyun Rhee1, John K. Hewitt1
1Institute for Behavioral Genetics, University of Colorado, USA

Tóm tắt

Background: We used variable threshold models which accounted for age and gender differences to investigate the genetic and environmental influences on DSM‐IV conduct disorder (CD) at the level of symptoms, aggressive versus non‐aggressive domains, and full‐scale.Method: A community sample of 1100 twin pairs (age 11–18) was interviewed using the Diagnostic Interview Schedule for Children.Results: Behavior genetic model fitting suggested that genetic and environmental influences on individual symptoms varied by symptom. The best‐fitting models for aggressive and non‐aggressive domains, and full‐scale CD included additive genetic effects and unique environmental effects only (AE models). These effects could be constrained across age cohorts and sex. The results suggest that using models that incorporate age‐ and gender‐appropriate thresholds specific to each subject we can account for prevalence differences between cohorts. Heritability estimates were .49, .55 and .53 for the aggressive domain, non‐aggressive domain, and full‐scales, respectively. These results are in contrast to previous research on antisocial behavior measured with the CBCL reporting higher heritability for aggressive versus non‐aggressive domains.Conclusions: Results suggest that individual symptoms of CD may be differentially heritable. Additionally, CD assessed using DSM‐IV criteria may show differing patterns of heritability compared with estimates obtained for other measures of antisocial behavior such as the CBCL.

Từ khóa


Tài liệu tham khảo

Achenbach T.M., 1991, Manual for the Child Behavior Checklist and 1991 Profile

APA, 1994, Diagnostic and statistical manual of mental disorders

10.1111/1467-8624.00011

10.1176/ajp.156.10.1515

10.1111/j.1469-7610.1997.tb01614.x

10.1111/j.1469-7610.1995.tb01328.x

10.1017/S095457940300021X

10.1111/1467-8624.00012

10.1007/BF01670099

10.1001/archpsyc.58.3.237

10.1017/S0033291797005643

10.1111/j.1469-7610.1997.tb01613.x

10.1017/S0033291799002561

10.1017/S0954579402002110

10.1046/j.1360-0443.2000.9568735.x

10.1097/00004583-199804000-00022

10.1097/00004583-199007000-00017

10.1001/archpsyc.1995.03950230020005

10.1097/00004583-200103000-00009

10.1016/S0376-8716(97)00156-7

10.1037/0033-295X.100.4.674

10.1176/ajp.155.4.479

Neale M.C., 1999, Mx: Statistical modeling

10.1098/rsta.1900.0024

Plomin R., 1990, Individual differences in infancy: Reliability, stability, prediction, 431

10.1037/0033-2909.128.3.490

Robins L., 1996, The Diagnostic Interview Schedule Version IV

Robinson J.L., 2001, Infancy to early childhood: Genetic and environmental influences on developmental change, 23, 10.1093/oso/9780195130126.003.0003

SAS, 1989, SAS Institute Inc., SAS/STAT User's Guide

10.1111/j.1469-7610.1995.tb01674.x

10.1136/bmj.323.7306.191

10.1097/00004583-199305000-00023

Simonoff E., 1998, Genetic and environmental influences on subtypes of conduct disorder behavior in boys, Journal of Abnormal Child Psychology, 26, 495

10.1007/s11920-001-0014-1

10.1037/0021-843X.106.2.266

10.1037/0021-843X.111.1.124

10.1111/j.1530-0277.1999.tb04181.x

10.1002/1097-4679(199103)47:2<310::AID-JCLP2270470219>3.0.CO;2-U

10.1016/0376-8716(94)01069-W

10.1002/1096-8628(20001009)96:5<684::AID-AJMG16>3.0.CO;2-G

Thông tin
Thông tin xuất bản

Journal of Child Psychology and Psychiatry and Allied Disciplines

Tập 46 Số 6

580-591

Thông tin tác giả