Genetic and Metabolic Determinants of Plasma PCSK9 Levels

Journal of Clinical Endocrinology and Metabolism - Tập 94 Số 7 - Trang 2537-2543 - 2009
Susan C. Gilchrist1, Thomas A. Lagace2, Jonathan C. Cohen1, Jay D. Horton1,2, Helen H. Hobbs1,2,3
1Donald W. Reynolds Cardiovascular Clinical Research Center, Departments of Internal Medicine (S.G.L., J.C.C., J.D.H., H.H.H.), University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046
2Molecular Genetics (T.A.L., J.D.H., H.H.H.), University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046
3The Howard Hughes Medical Institute (H.H.H.), University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046

Tóm tắt

Từ khóa


Tài liệu tham khảo

Seidah, 2003, The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation., Proc Natl Acad Sci USA, 100, 928, 10.1073/pnas.0335507100

Cohen, 2005, Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9., Nat Genet, 37, 161, 10.1038/ng1509

Kotowski, 2006, A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol., Am J Hum Genet, 78, 410, 10.1086/500615

Abifadel, 2003, Mutations in PCSK9 cause autosomal dominant hypercholesterolemia., Nat Genet, 34, 154, 10.1038/ng1161

Cohen, 2006, Sequence variations in PCSK9, low LDL, and protection against coronary heart disease., N Engl J Med, 354, 1264, 10.1056/NEJMoa054013

Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis., Science, 232, 34, 10.1126/science.3513311

Horton, 2007, Molecular biology of PCSK9: its role in LDL metabolism., Trends Biochem Sci, 32, 71, 10.1016/j.tibs.2006.12.008

Zaid, 2008, Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration., Hepatology, 48, 646, 10.1002/hep.22354

Lagace, 2006, Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice., J Clin Invest, 116, 2995, 10.1172/JCI29383

Alborn, 2007, Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterol., Clin Chem, 53, 1814, 10.1373/clinchem.2007.091280

Lambert, 2008, Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment., Clin Chem, 54, 1038, 10.1373/clinchem.2007.099747

Mayne, 2008, Plasma PCSK9 levels are significantly modified by statins and fibrates in humans, Lipids Health Dis, 7, 22, 10.1186/1476-511X-7-22

Victor, 2004, The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health., Am J Cardiol, 93, 1473, 10.1016/j.amjcard.2004.02.058

Frank-Kamenetsky, 2008, Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates., Proc Natl Acad Sci USA, 105, 11915, 10.1073/pnas.0805434105

Zhao, 2006, Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote., Am J Hum Genet, 79, 514, 10.1086/507488

Chang, 2007, Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study., J Am Coll Cardiol, 49, 109, 10.1016/j.jacc.2006.10.040

Careskey, 2008, Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9., J Lipid Res, 49, 394, 10.1194/jlr.M700437-JLR200

Boerwinkle, 1988, Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism., Am J Hum Genet, 42, 104

Dubuc, 2004, Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia., Arterioscler Thromb Vasc Biol, 24, 1454, 10.1161/01.ATV.0000134621.14315.43

Rashid, 2005, Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9., Proc Natl Acad Sci USA, 102, 5374, 10.1073/pnas.0501652102

Mayne, 2007, Plasma PCSK9 levels correlate with cholesterol in men but not in women., Biochem Biophys Res Commun, 361, 451, 10.1016/j.bbrc.2007.07.029

Horton, 2003, Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes., Proc Natl Acad Sci USA, 100, 12027, 10.1073/pnas.1534923100

Grefhorst, 2008, Plasma PCSK9 preferentially reduces liver LDL receptors in mice., J Lipid Res, 49, 1303, 10.1194/jlr.M800027-JLR200

Luo, 6 2008, Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice., J Lipid Res, in press

Costet, 2006, Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c., J Biol Chem, 281, 6211, 10.1074/jbc.M508582200

Browning, 2004, Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity., Hepatology, 40, 1387, 10.1002/hep.20466