Genetic Prediction of Lifetime Risk of Fracture

citation_title=Meta-analysis: excess mortality after hip fracture among older women and men; citation_author=Haentjens P; citation_author=Magaziner J; citation_author=Colon-Emeric CS; citation_journal_title=Ann Intern Med; citation_year=2010; citation_volume=152; citation_issue=6; citation_pages=380-390; citation_title=Fracture risk assessment: from population to individual; citation_author=Nguyen TV; citation_author=Eisman JA; citation_journal_title=J Clin Densitom; citation_year=2017; citation_volume=20; citation_issue=3; citation_pages=368-378; citation_title=The impact of fragility fracture and approaches to osteoporosis risk assessment worldwide; citation_author=Curtis EM; citation_author=Moon RJ; citation_author=Harvey NC; citation_author=Cooper C; citation_journal_title=Bone; citation_year=2017; citation_volume=104; citation_issue=Supplement C; citation_pages=29-38; citation_title=Persistence of excess mortality following individual nonhip fractures: a relative survival analysis; citation_author=Tran T; citation_author=Bliuc D; citation_author=Hansen L; citation_journal_title=J Clin Endocrinol Metab; citation_year=2018; citation_volume=103; citation_issue=9; citation_pages=3205-3214; citation_title=Estimation of the lifetime risk of hip fracture for women and men in Canada; citation_author=Hopkins RB; citation_author=Pullenayegum E; citation_author=Goeree R; citation_journal_title=Osteoporos Int; citation_year=2012; citation_volume=23; citation_issue=3; citation_pages=921-927; citation_title=Recent trends in the incidence and lifetime risk of hip fracture in Tottori, Japan; citation_author=Hagino H; citation_author=Furukawa K; citation_author=Fujiwara S; citation_journal_title=Osteoporos Int; citation_year=2009; citation_volume=20; citation_issue=4; citation_pages=543-548; citation_title=Residual lifetime and 10 year absolute risks of osteoporotic fractures in Chinese men and women; citation_author=Si L; citation_author=Winzenberg TM; citation_author=Chen M; citation_author=Jiang Q; citation_author=Palmer AJ; citation_journal_title=Curr Med Res Opin; citation_year=2015; citation_volume=31; citation_issue=6; citation_pages=1149-1156; citation_title=The incidence and residual lifetime risk of osteoporosis-related fractures in Korea; citation_author=Park C; citation_author=Ha Y-C; citation_author=Jang S; citation_author=Jang S; citation_author=Yoon H-K; citation_author=Lee Y-K; citation_journal_title=J Bone Miner Metab; citation_year=2011; citation_volume=29; citation_issue=6; citation_pages=744-751; citation_title=Residual lifetime risk for developing hypertension in middle-aged women and men: the Framingham Heart Study; citation_author=Vasan RS; citation_author=Beiser A; citation_author=Seshadri S; citation_journal_title=JAMA; citation_year=2002; citation_volume=287; citation_issue=8; citation_pages=1003-1010; citation_title=The gender- and age-specific 10-year and lifetime absolute fracture risk in Tromsø, Norway; citation_author=Ahmed LA; citation_author=Schirmer H; citation_author=Bjørnerem Å; citation_journal_title=Eur J Epidemiol; citation_year=2009; citation_volume=24; citation_issue=8; citation_pages=441-448; citation_title=Residual lifetime risk of fractures in women and men; citation_author=Nguyen ND; citation_author=Ahlborg HG; citation_author=Center JR; citation_author=Eisman JA; citation_author=Nguyen TV; citation_journal_title=J Bone Miner Res; citation_year=2007; citation_volume=22; citation_issue=6; citation_pages=781-788; citation_title=BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure; citation_author=Nethander M; citation_author=Pettersson-Kymmer U; citation_author=Vandenput L; citation_journal_title=J Clin Endocrinol Metab; citation_year=2020; citation_volume=105; citation_issue=4; citation_pages=e1344-e1357; citation_title=GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures; citation_author=Styrkarsdottir U; citation_author=Stefansson OA; citation_author=Gunnarsdottir K; citation_journal_title=Nat Commun; citation_year=2019; citation_volume=10; citation_issue=1; citation_pages=2054 citation_title=Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture; citation_author=Estrada K; citation_author=Styrkarsdottir U; citation_author=Evangelou E; citation_journal_title=Nat Genet; citation_year=2012; citation_volume=44; citation_issue=5; citation_pages=491-501; citation_title=An atlas of genetic influences on osteoporosis in humans and mice; citation_author=Morris JA; citation_author=Kemp JP; citation_author=Youlten SE; citation_journal_title=Nat Genet; citation_year=2019; citation_volume=51; citation_issue=2; citation_pages=258-266; citation_title=Multiple genetic loci for bone mineral density and fractures; citation_author=Styrkarsdottir U; citation_author=Halldorsson BV; citation_author=Gretarsdottir S; citation_journal_title=N Engl J Med; citation_year=2008; citation_volume=358; citation_issue=22; citation_pages=2355-2365; citation_title=Prediction of bone mineral density and fragility fracture by genetic profiling; citation_author=Ho-Le TP; citation_author=Center JR; citation_author=Eisman JA; citation_author=Nguyen HT; citation_author=Nguyen TV; citation_journal_title=J Bone Miner Res; citation_year=2017; citation_volume=32; citation_issue=2; citation_pages=285-293; citation_title=Prediction of osteoporotic fractures by postural instability and bone density; citation_author=Nguyen T; citation_author=Sambrook P; citation_author=Kelly P; citation_journal_title=BMJ; citation_year=1993; citation_volume=307; citation_issue=6912; citation_pages=1111-1115; citation_title=The Dubbo study: an Australian prospective community study of the health of elderly; citation_author=Simons LA; citation_author=McCallum J; citation_author=Simons J; citation_journal_title=Aust N Z J Med; citation_year=1990; citation_volume=20; citation_issue=6; citation_pages=783-789; citation_title=Reference ranges for bone densitometers adopted Australia-wide: Geelong Osteoporosis Study; citation_author=Henry MJ; citation_author=Pasco JA; citation_author=Pocock NA; citation_author=Nicholson GC; citation_author=Kotowicz MA; citation_journal_title=Australas Radiol; citation_year=2004; citation_volume=48; citation_issue=4; citation_pages=473-475; citation_title=Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering; citation_author=Browning SR; citation_author=Browning BL; citation_journal_title=Am J Hum Genet; citation_year=2007; citation_volume=81; citation_issue=5; citation_pages=1084-1097; Ho-Le TP,Tran TS,Nguyen HG,Center JC,Eisman JA,Nguyen TV. Genetic prediction of lifetime risk of fracture. Published April 12 2023. figshare. https://doi.org/10.6084/m9.figshare.22597975 Australian Institute of Health and Welfare. Life expectancy and disability in Australia: expected years living with and without disability. 2017. https://www.aihw.gov.au/reports/disability/life-expectancy-and-disability-in-australia-expected-years-living-with-and-without-disability/summary. Accessed 10 February 2020. citation_title=Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age; citation_author=Lloyd-Jones DM; citation_author=Leip EP; citation_author=Larson MG; citation_journal_title=Circulation; citation_year=2006; citation_volume=113; citation_issue=6; citation_pages=791-798; citation_title=Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro; citation_author=Beiser A; citation_author=D'Agostino RB; citation_author=Seshadri S; citation_author=Sullivan LM; citation_author=Wolf PA; citation_journal_title=Stat Med; citation_year=2000; citation_volume=19; citation_issue=11-12; citation_pages=1495-1522; citation_author=Grambsch PM; citation_author=Therneau TM; citation_publisher=Springer-Verlag New York Springer, ; citation_title=Modeling Survival Data: Extending the Cox Model; citation_year=2000; citation_author=R Core Team; citation_publisher=R Foundation for Statistical Computing, ; citation_title=R: A Language and Environment for Statistical Computing; citation_year=2020; citation_author=Jui-Chung Allen L; citation_publisher=SAGE publication Inc, ; citation_title=Modeling Survival Data: Extending the Cox Model; citation_year=2003; citation_pages=117-120; citation_title=Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects; citation_author=Eriksson J; citation_author=Evans DS; citation_author=Nielson CM; citation_journal_title=J Bone Miner Res; citation_year=2015; citation_volume=30; citation_issue=1; citation_pages=184-194; citation_title=Prediction of future osteoporotic fracture occurrence by genetic profiling: a 6-year follow-up observational study; citation_author=Lee SH; citation_author=Cho E-H; citation_author=Ahn SH; citation_journal_title=J Clin Endocrinol Metab; citation_year=2016; citation_volume=101; citation_issue=3; citation_pages=1215-1224; citation_title=Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture; citation_author=Kim SK; citation_journal_title=PLoS One; citation_year=2018; citation_volume=13; citation_issue=7; citation_pages=e0200785 citation_title=Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures; citation_author=Tranah GJ; citation_author=Taylor BC; citation_author=Lui LY; citation_journal_title=Calcif Tissue Int; citation_year=2008; citation_volume=83; citation_issue=3; citation_pages=155-166; citation_title=Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study; citation_author=Forgetta V; citation_author=Keller-Baruch J; citation_author=Forest M; citation_journal_title=PLoS Med; citation_year=2020; citation_volume=17; citation_issue=7; citation_pages=e1003152 citation_title=Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies; citation_author=Chatterjee N; citation_author=Wheeler B; citation_author=Sampson J; citation_author=Hartge P; citation_author=Chanock SJ; citation_author=Park JH; citation_journal_title=Nat Genet; citation_year=2013; citation_volume=45; citation_issue=4; citation_pages=400-405; citation_title=Development of prognostic nomograms for individualizing 5-year and 10-year fracture risks; citation_author=Nguyen ND; citation_author=Frost SA; citation_author=Center JR; citation_author=Eisman JA; citation_author=Nguyen TV; citation_journal_title=Osteoporos Int; citation_year=2008; citation_volume=19; citation_issue=10; citation_pages=1431-1444; citation_title=FRAX And the assessment of fracture probability in men and women from the UK; citation_author=Kanis JA; citation_author=Johnell O; citation_author=Oden A; citation_author=Johansson H; citation_author=McCloskey E; citation_journal_title=Osteoporos Int; citation_year=2008; citation_volume=19; citation_issue=4; citation_pages=385-397; citation_title=External validation of the Garvan nomograms for predicting absolute fracture risk: the Tromsø study; citation_author=Ahmed LA; citation_author=Nguyen ND; citation_author=Bjørnerem Å; citation_journal_title=PLoS One; citation_year=2014; citation_volume=9; citation_issue=9; citation_pages=e107695 citation_title=Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration; citation_author=Leslie WD; citation_author=Lix LM; citation_author=Johansson H; citation_author=Oden A; citation_author=McCloskey E; citation_author=Kanis JA; citation_journal_title=J Bone Miner Res; citation_year=2010; citation_volume=25; citation_issue=11; citation_pages=2350-2358; citation_title=External validation and comparison of three prediction tools for risk of osteoporotic fractures using data from population based electronic health records: retrospective cohort study; citation_author=Dagan N; citation_author=Cohen-Stavi C; citation_author=Leventer-Roberts M; citation_author=Balicer RD; citation_journal_title=BMJ; citation_year=2017; citation_volume=356; citation_pages=i6755 citation_title=FRAX® tool, the WHO algorithm to predict osteoporotic fractures: the first analysis of its discriminative and predictive ability in the Spanish FRIDEX cohort; citation_author=Azagra R; citation_author=Roca G; citation_author=Encabo G; citation_journal_title=BMC Musculoskelet Disord; citation_year=2012; citation_volume=13; citation_issue=1; citation_pages=204 citation_title=Evaluation of the FRAX and Garvan fracture risk calculators in older women; citation_author=Bolland MJ; citation_author=Siu AT; citation_author=Mason BH; citation_journal_title=J Bone Miner Res; citation_year=2011; citation_volume=26; citation_issue=2; citation_pages=420-427; citation_title=FRAX Facts; citation_author=Watts NB; citation_author=Ettinger B; citation_author=LeBoff MS; citation_journal_title=J Bone Miner Res; citation_year=2009; citation_volume=24; citation_issue=6; citation_pages=975-979; citation_title=Assessing the clinical utility of genetic profiling in fracture risk prediction: a decision curve analysis; citation_author=Ho-Le TP; citation_author=Tran HTT; citation_author=Center JR; citation_author=Eisman JA; citation_author=Nguyen HT; citation_author=Nguyen TV; citation_journal_title=Osteoporos Int; citation_year=2021; citation_volume=32; citation_issue=2; citation_pages=271-280; citation_title=Genetic risk scores implicated in adult bone fragility associate with pediatric bone density; citation_author=Mitchell JA; citation_author=Chesi A; citation_author=Elci O; citation_journal_title=J Bone Miner Res; citation_year=2016; citation_volume=31; citation_issue=4; citation_pages=789-795; citation_title=The utility of genetic risk score to improve performance of FRAX for fracture prediction in US postmenopausal women; citation_author=Xiao X; citation_author=Wu Q; citation_journal_title=Calcif Tissue Int; citation_year=2021; citation_volume=108; citation_issue=6; citation_pages=746-756; citation_title=Genetic profiling and individualized assessment of fracture risk; citation_author=Nguyen TV; citation_author=Eisman JA; citation_journal_title=Nat Rev Endocrinol; citation_year=2013; citation_volume=9; citation_issue=3; citation_pages=153-161; citation_title=Genomic risk prediction of coronary artery disease in 480,000 adults; citation_author=Inouye M; citation_author=Abraham G; citation_author=Nelson CP; citation_journal_title=J Am Coll Cardiol; citation_year=2018; citation_volume=72; citation_issue=16; citation_pages=1883-1893; citation_title=Development and validation of a residual risk score to predict breast cancer risk in unaffected women negative for mutations on a multi-gene hereditary cancer panel; citation_author=Hughes E; citation_author=Judkins T; citation_author=Wagner S; citation_author=Wenstrup RJ; citation_author=Lanchbury JS; citation_author=Gutin A; citation_journal_title=J Clin Oncol; citation_year=2017; citation_volume=35; citation_issue=15_suppl; citation_pages=1579 citation_title=Polygenic risk score for breast cancer in high-risk women; citation_author=Black MH; citation_author=Li S; citation_author=LaDuca H; citation_journal_title=J Clin Oncol; citation_year=2018; citation_volume=36; citation_issue=15_suppl; citation_pages=1508 citation_title=American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update; citation_author=Camacho PM; citation_author=Petak SM; citation_author=Binkley N; citation_journal_title=Endocr Pract; citation_year=2020; citation_volume=26; citation_issue=Suppl 1; citation_pages=1-46; citation_title=Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society* clinical practice guideline; citation_author=Eastell R; citation_author=Rosen CJ; citation_author=Black DM; citation_author=Cheung AM; citation_author=Murad MH; citation_author=Shoback D; citation_journal_title=J Clin Endocrinol Metab; citation_year=2019; citation_volume=104; citation_issue=5; citation_pages=1595-1622; citation_title=UK Clinical guideline for the prevention and treatment of osteoporosis; citation_author=Gregson CL; citation_author=Armstrong DJ; citation_author=Bowden J; citation_journal_title=Arch Osteoporos; citation_year=2022; citation_volume=17; citation_issue=1; citation_pages=58 citation_author=Kanis JA; citation_publisher=WHO Collaborating Centre, University of Sheffield, Technical Report, ; citation_title=Assessment of Osteoporosis at the Primary Health-Care Level; citation_year=2008; citation_title=European Guidance for the diagnosis and management of osteoporosis in postmenopausal women; citation_author=on behalf on the Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF); citation_author=Kanis JA; citation_author=Cooper C; citation_author=Rizzoli R; citation_author=Reginster JY; citation_journal_title=Osteoporos Int; citation_year=2019; citation_volume=30; citation_issue=1; citation_pages=3-44; citation_title=Clinical use of current polygenic risk scores may exacerbate health disparities; citation_author=Martin AR; citation_author=Kanai M; citation_author=Kamatani Y; citation_author=Okada Y; citation_author=Neale BM; citation_author=Daly MJ; citation_journal_title=Nat Genet; citation_year=2019; citation_volume=51; citation_issue=4; citation_pages=584-591;