Generation of a human induced pluripotent stem cell line (UEFi003-A) carrying heterozygous A673T variant in amyloid precursor protein associated with a reduced risk of Alzheimer’s disease

Stem Cell Research - Tập 48 - Trang 101968 - 2020
Taisia Rolova1, Ying-Chieh Wu1, Marja Koskuvi1,2, Jenni Voutilainen2, Tuuli-Maria Sonninen2, Johanna Kuusisto3, Markku Laakso3, Riikka H. Hämäläinen2, Jari Koistinaho1,2, Šárka Lehtonen1,2
1Neuroscience Center, University of Helsinki, Helsinki, Finland
2A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
3Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland

Tài liệu tham khảo

Brothers, 2018, The physiological roles of amyloid-β peptide hint at new ways to treat Alzheimer's disease, Front. Aging Neurosci., 10, 118, 10.3389/fnagi.2018.00118

Jonsson, 2012, A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline, Nature, 488, 96, 10.1038/nature11283

Lehtonen, 2018, Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease, Stem Cell Res., 30, 96, 10.1016/j.scr.2018.05.014

Maloney, J.A., Bainbridge, T., Gustafson, A., Zhang, S., Kyauk, R., Steiner, P., van der Brug, M., Liu, Y., Ernst, J.A., Watts, R.J., Atwal, J.K., 2014. Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein. J. Biol. Chem. 89(45), 30990–31000.

Nicolas, 2014, Amyloid precursor protein and neural development, Development, 141, 2543, 10.1242/dev.108712

Thông tin
Thông tin xuất bản

Stem Cell Research

Tập 48

101968

Thông tin tác giả