Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

American Association for the Advancement of Science (AAAS) - Tập 261 Số 5123 - Trang 921-923 - 1993
Elizabeth H. Corder1, Ann M. Saunders1, Warren J. Strittmatter1, Donald E. Schmechel2, P C Gaskell1, Gary W. Small3, Tommy Martinsson1, J. L. Haines4, Jeffery M. Vance1
1Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710.
2Department of Medicine, Neurology, and Neurobiology, Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710, and Durham VA Medical Center, Durham, NC 27710.
3Neuropsychiatric Institute and Hospital, Center for Health Sciences, University of California, Los Angeles, CA 90024.
4Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, MA, 02129

Tóm tắt

The apolipoprotein E type 4 allele ( APOE -ε4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE -ε4 alleles in 42 families with late onset AD. Thus APOE -ε4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE -ε4 was virtually sufficient to cause AD by age 80.

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American Association for the Advancement of Science (AAAS)

Tập 261 Số 5123

921-923

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