Gender Differences in the Presentation and Outcomes of Hospitalized Patients With COVID‐19

Journal of Hospital Medicine - Tập 16 Số 6 - Trang 349-352 - 2021
Carloalberto Biolè1, Matteo Bianco1, Iván J. Núñez‐Gil2, Enrico Cerrato1,3, A. Spirito1, Sergio Raposeiras‐Roubín4, María C. Viana‐Llamas5, Adelina González6, Alex F. Castro‐Mejía7, Emilio Alfonso8, Cristina Fernández9, Aitor Uribarri10, Emilio Alfonso‐Rodríguez11, Fabrizio Ugo12, Federico Guerra13, Gisela Feltes14, İbrahim Akın15,16, Inmaculada Fernández‐Rozas17, Natividad Blasco‐Angulo18, Jia Huang19, Marcos Garcı́a Aguado20, Martino Pepe21, Rodolfo Romero22, Víctor Manuel Becerra‐Muñoz23, Vicente Estrada2, Carlos Macaya2
1Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano (Turin), Italy
2Hospital Clínico San Carlos, Madrid, Spain
3Interventional Cardiology Unit, San Luigi Gonzaga University Hospital, Orbassano, and Rivoli Infermi Hospital, Rivoli, Turin, Italy
4University Hospital Álvaro Cunqueiro, Vigo, Spain
5Hospital Universitario Guadalajara, Guadalajara, Spain
6Hospital Universitario Infanta Sofia, San Sebastian de Los Reyes, Madrid, Spain
7Hospital General del norte de Guayaquil IESS, Los Ceibos, Ecuador
8Hospital La Paz, Madrid, Spain
9Hospital Santiago de Compostela, Santiago de Compostela, Spain
10Hospital Clínico Universitario de Valladolid, Valladolid, Spain
11Instituto de Cardiología y Cirugía Cardiovascular, Havana, Cuba
12Sant'Andrea Hospital, Vercelli, Italy
13Cardiology and Arrhythmology Clinic, Ospedali Riuniti "Umberto I - Lancisi - Salesi", Ancona, Italy
14Hospital Nuestra Señora de América, Madrid, Spain
15First Department of Medicine, University Heidelberg, Mannheim, Germany
16German Center for Cardiovascular Research, Heidelberg-Mannheim, Mannheim, Germany
17Hospital Severo Ochoa, Leganés, Spain
18Instituto de Investigación Sanitaria Incliva, Universidad de Valencia Valencia Spain
19The Second People's Hospital Of Shenzhen, Shenzhen, China
20Hospital Puerta de Hierro, Majadahonda, Spain
21Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy
22Hospital Universitario Getafe, Madrid, Spain
23Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain

Tóm tắt

Gender‐related differences in COVID‐19 clinical presentation, disease progression, and mortality have not been adequately explored. We analyzed the clinical profile, presentation, treatments, and outcomes of patients according to gender in the HOPE‐COVID‐19 International Registry. Among 2,798 enrolled patients, 1,111 were women (39.7%). Male patients had a higher prevalence of cardiovascular risk factors and more comorbidities at baseline. After propensity score matching, 876 men and 876 women were selected. Male patients more often reported fever, whereas female patients more often reported vomiting, diarrhea, and hyposmia/anosmia. Laboratory tests in men presented alterations consistent with a more severe COVID‐19 infection (eg, significantly higher C‐reactive protein, troponin, transaminases, lymphocytopenia, thrombocytopenia, and ferritin). Systemic inflammatory response syndrome, bilateral pneumonia, respiratory insufficiency, and renal failure were significantly more frequent in men. Men more often required pronation, corticosteroids, and tocilizumab administration. A significantly higher 30‐day mortality was observed in men vs women (23.4% vs 19.2%; P = .039). Trial Numbers: NCT04334291/EUPAS34399.

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Tài liệu tham khảo

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Journal of Hospital Medicine

Tập 16 Số 6

349-352

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