Gefitinib kết hợp với Paclitaxel và Carboplatin trong điều trị ung thư phổi không tế bào nhỏ giai đoạn nặng: Thử nghiệm pha III—INTACT 2
Tóm tắt
Từ khóa
#Gefitinib #Paclitaxel #Carboplatin #Non-Small-Cell Lung Cancer #Phase III TrialTài liệu tham khảo
Parkin DM, Bray FI, Devesa SS: Cancer burden in the year 2000: The global picture. Eur J Cancer 37:S4,2001–S66, (suppl 8)
Natale RB, Skarin A, Maddox A-M, et al: Improvement in symptoms and quality of life for advanced non–small-cell lung cancer patients receiving ZD1839 (‘Iressa’) in IDEAL 2. Proc Am Soc Clin Oncol 21:292a,2002, (abstr 1167)
Ciardiello F, Caputo R, Bianco R, et al: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053,2000–2063,
Sirotnak FM, Zakowski MF, Miller VA, et al: Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 6:4885,2000–4892,
Ravindranath N, Wion D, Brachet P, et al: Epidermal growth factor modulates the expression of vascular endothelial growth factor in the human prostate. J Androl 22:432,2001–443,
Morikawa K, Walker SM, Nakajima M, et al: Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res 48:6863,1988–6871,
Meye A, Fiedler U, Kunert K, et al: Growth inhibitory effects of ZD1839 (‘Iressa’) on human bladder cancer cell lines. Proc Am Assoc Cancer Res 42:805,2001, (abstr 4320)
Moasser MM, Basso A, Averbuch SD, et al: The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 61:7184,2001–7188,
Janmaat ML, Kruyt FAE, Rodriquez JA, et al: Inhibition of the epidermal growth factor receptor induces apoptosis in A431 cells, but not in non-small-cell lung cancer cell lines. Proc Am Assoc Cancer Res 43:XX,2002, (abstr 3901)
Budillon A, Guarrasi R, Di Gennaro E, et al: ZD1839 (‘Iressa’), an EGFR tyrosine kinase inhibitor, potentiates non-Mhc restricted cytotoxicity in human cancer cell lines. Proc Am Assoc Cancer Res 42:XX,2001, (abstr 4306)
Janas MS, Franklin WA, Schmidt K, et al: Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer. Proc Am Assoc Cancer Res 44:XX,2003, (abstr LB-213)
Bailey LR, Kris M, Wolf M, et al: Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib (‘Iressa’, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Assoc Cancer Res 44:1362,2003, (abstr LB-170)