Gastrodin Điều Chỉnh Đường Dẫn Truyền PI3K/AKT-Sirt3 và Các Chất Trung Gian Gây Viêm Trong Tế Bào Thần Kinh Microglia Được Kích Hoạt

Guo J, Zhang X L, Bao Z R et al (2021) Gastrodin regulates the Notch Signaling Pathway and Sirt3 in activated Microglia in Cerebral hypoxic-ischemia neonatal rats and in activated BV-2 microglia [J]. Neuromolecular Med 23(3):348–362 Li SJ, Liu W, Wang JL et al (2014) The role of TNF-α, IL-6, IL-10, and GDNF in neuronal apoptosis in neonatal rat with hypoxic-ischemic encephalopathy [J]. Eur Rev Med Pharmacol Sci 18(6):905–909 Huang J Z, Ren Y, Jiang Y et al (2018) GluR1 protects hypoxic ischemic brain damage via activating akt signaling pathway in neonatal rats [J]. Eur Rev Med Pharmacol Sci 22(24):8857–8865 Jellema R K, Lima Passos V, Zwanenburg A et al (2013) Cerebral inflammation and mobilization of the peripheral immune system following global hypoxia-ischemia in preterm sheep [J]. J Neuroinflammation 10:13 Guo L, Wang D, BO G et al (2016) Early identification of hypoxic-ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy [J]. Experimental and Therapeutic Medicine 12(5):2835–2842 Yang L, Zhao H (2020) Treatment and new progress of neonatal hypoxic-ischemic brain damage [J]. Histol Histopathol 35(9):929–936 Du Plessis A J, Volpe JJ (2002) Perinatal brain injury in the preterm and term newborn [J]. Curr Opin Neurol 15(2):151–157 Liu F, Mccullough LD (2013) Inflammatory responses in hypoxic ischemic encephalopathy [J]. Acta Pharmacol Sin 34(9):1121–1130 Kreutzberg G W (1996) Microglia: a sensor for pathological events in the CNS [J]. Trends Neurosci 19(8):312–318 Yenari M A, Kauppinen T M, Swanson RA (2010) Microglial activation in Stroke: therapeutic targets [J]. Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics 7(4):378–391 El Khoury J, Hickman S E, Thomas C A et al (1998) Microglia, scavenger receptors, and the pathogenesis of Alzheimer’s Disease [J]. Neurobiol Aging 19(1 Suppl):S81–S84 Thomas W E (1992) Brain macrophages: evaluation of microglia and their functions [J]. Brain Res Brain Res Rev 17(1):61–74 Zheng Z, Yenari MA (2004) Post-ischemic inflammation: molecular mechanisms and therapeutic implications [J]. Neurol Res 26(8):884–892 Davies C A, Loddick S A, Stroemer R P et al (1998) An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat [J]. Exp Neurol 154(1):199–212 Schroeter M, Jander S, Witte O W et al (1994) Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion [J]. J Neuroimmunol 55(2):195–203 Walker D G, Lue L F (2015) Immune phenotypes of microglia in human neurodegenerative Disease: challenges to detecting microglial polarization in human brains [J]. Alzheimers Res Ther 7(1):56 Perego C, Fumagalli S, De Simoni M G (2011) Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice [J]. J Neuroinflammation 8:174 Fumagalli S, Perego C, Ortolano F et al (2013) CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice [J]. Glia 61(6):827–842 He Y, Gao Y, Zhang Q et al (2020) IL-4 switches Microglia/macrophage M1/M2 polarization and alleviates neurological damage by modulating the JAK1/STAT6 pathway following ICH [J]. Neuroscience 437:161–171 Tang Y (2016) Differential roles of M1 and M2 microglia in neurodegenerative Diseases [J]. Mol Neurobiol 53(2):1181–1194 Kaur C, Rathnasamy G, Ling EA (2013) Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina [J]. J Neuroimmune Pharmacol 8(1):66–78 Del Bigio M R, Becker LE (1994) Microglial aggregation in the dentate gyrus: a marker of mild hypoxic-ischaemic brain insult in human infants [J]. Neuropathol Appl Neurobiol 20(2):144–151 Disdier C, Stonestreet BS (2020) Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain [J]. J Neurosci Res 98(7):1468–1484 Pappas A, Shankaran S, Mcdonald S A et al (2015) Cognitive outcomes after neonatal encephalopathy [J]. Pediatrics 135(3):e624–e634 Gluckman P D, Wyatt JS (2005) Selective head cooling with mild systemic Hypothermia after neonatal encephalopathy: multicentre randomised trial [J]. Lancet (London England) 365(9460):663–670 Kim HJ, Moon K D, Oh S Y et al (2001) Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus [J]. Neuroscience letters, 314(1–2): 65 – 8 Dai J N, Zong Y, Zhong L M et al (2011) Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways [J]. PLoS ONE 6(7):e21891 Peng Z, Wang S, Chen G et al (2015) Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway [J]. Neurochem Res 40(4):661–673 Li X, Zhang J, Zhu X et al (2015) Progesterone reduces inflammation and apoptosis in neonatal rats with hypoxic ischemic brain damage through the PI3K/Akt pathway [J]. Int J Clin Exp Med 8(5):8197–8203 Narayanankutty A (2019) PI3K/ Akt/ mTOR pathway as a therapeutic target for Colorectal Cancer: a review of preclinical and clinical evidence [J]. Curr Drug Targets 20(12):1217–1226 Kamada H, Nito C, Endo H et al (2007) Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats [J]. J Cereb Blood Flow Metab 27(3):521–533 Ma X H, Gao Q, Jia Z et al (2015) Neuroprotective capabilities of TSA against cerebral ischemia/reperfusion injury via PI3K/Akt signaling pathway in rats [J]. Int J Neurosci 125(2):140–146 Yang W, Liu Y, Xu Q Q et al (2020) Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease [J]. Oxid Med Cell Longev, 2020: 4754195 Fu X, Chen H (2020) C16 peptide and angiopoietin-1 protect against LPS-induced BV-2 microglial cell inflammation [J]. Life Sci 256:117894 Zhang B, Yang N, Mo ZM et al (2017) IL-17A enhances microglial response to OGD by regulating p53 and PI3K/Akt pathways with involvement of ROS/HMGB1 [J]. Front Mol Neurosci 10:271 North B J Verdine, Sirtuins (2004) Sir2-related NAD-dependent protein deacetylases [J]. Genome Biol 5(5):224 Li Y, Ma Y, Song L et al (2018) SIRT3 deficiency exacerbates p53/Parkin–mediated mitophagy inhibition and promotes mitochondrial dysfunction: implication for aged hearts [J]. Int J Mol Med 41(6):3517–3526 Jing E, Emanuelli B, Hirschey MD et al (2011) Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production [J]. Proc Natl Acad Sci U S A 108(35):14608–14613 Haigis M C, Deng C X, Finley L W et al (2012) SIRT3 is a mitochondrial Tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis [J]. Cancer Res 72(10):2468–2472 Alhazzazi T Y, Kamarajan P (2011) SIRT3 and cancer: Tumor promoter or suppressor? [J]. Biochim Biophys Acta 1816(1):80–88 Ahn B H, Kim H S Songs et al (2008) A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis [J]. Proc Natl Acad Sci U S A 105(38):14447–14452 Wang X, Dai Y, Zhang X et al (2021) CXCL6 regulates cell permeability, proliferation, and apoptosis after ischemia-reperfusion injury by modulating Sirt3 expression via AKT/FOXO3a activation [J], vol 22. Cancer biology & therapy, pp 30–39. 1 Wang Z, Li Y, Wang Y et al (2019) Pyrroloquinoline quinine protects HK-2 cells against high glucose-induced oxidative stress and apoptosis through Sirt3 and PI3K/Akt/FoxO3a signaling pathway [J]. Biochem Biophys Res Commun 508(2):398–404 Semple BD, Blomgren K, Gimlin K et al (2013) Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species [J]. Prog Neurobiol 106–107:1–16 Min Y, Yan L, Wang Q et al (2020) Distinct residential and infiltrated macrophage populations and their phagocytic function in mild and severe neonatal hypoxic-ischemic brain damage [J]. Front Cell Neurosci 14:244 Liu SJ, Liu X Y, Li JH et al (2018) Gastrodin attenuates microglia activation through renin-angiotensin system and Sirtuin3 pathway [J]. Neurochem Int 120:49–63 Li C, Mo Z, Lei J et al (2018) Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway [J]. Int J Biochem Cell Biol 99:169–177 Liu X H, Yan H, Xu M et al (2013) Hyperbaric oxygenation reduces long-term brain injury and ameliorates behavioral function by suppression of apoptosis in a rat model of neonatal hypoxia-ischemia [J]. Neurochem Int 62(7):922–930 Huang J, Lu W, Doycheva D M et al (2020) IRE1alpha inhibition attenuates neuronal pyroptosis via miR-125/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model [J]. J Neuroinflammation 17(1):152 Li JJ, Lu J, Kaur C et al (2009) Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells [J]. Neuroscience 158(4):1488–1499 Livak K J, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method [J]. Methods 25(4):402–408 Rangarajan P, Karthikeyan A, LU J et al (2015) Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia [J]. Neuroscience 311:398–414 Hasegawa M, Ogihara T, Tamai H et al (2009) Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: reduction of oxidative stress and maintenance of the glutathione redox state [J]. Brain Res 1283:1–13 Inder T E, Volpe JJ (2000) Mechanisms of perinatal brain injury [J]. Semin Neonatol 5(1):3–16 Tan W K, Williams C E, During M J et al (1996) Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep [J]. Pediatr Res 39(5):791–797 Tan W K, Williams C E, Gunn A J et al (1992) Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep [J]. Ann Neurol 32(5):677–682 Macmanus JP, Buchan A M, Hill I E et al (1993) Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain [J]. Neurosci Lett 164(1–2):89–92 Beilharz E J, Williams C E, Dragunow M et al (1995) Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss [J]. Brain Res Mol Brain Res 29(1):1–14 Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo [J]. Science 308(5726):1314–1318 Iadecola C, Anrather J (2011) The immunology of Stroke: from mechanisms to translation [J]. Nat Med 17(7):796–808 Varnum MM (2012) The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer’s Disease brain [J]. Arch Immunol Ther Exp (Warsz) 60(4):251–266 Porta C, Rimoldi M, Raes G et al (2009) Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB [J]. Proc Natl Acad Sci U S A 106(35):14978–14983 Mantovani A, Sozzani S, Locati M et al (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes [J]. Trends Immunol 23(11):549–555 Liu Y, Gao J (2018) A review on Central Nervous System effects of Gastrodin [J]. Front Pharmacol 9:24 Yang P, Han Y (2013) Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling [J]. Biochem Pharmacol 85(8):1124–1133 Cheng C, Chen X, Wang Y et al (2021) MSCs–derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6 [J]. 27(1):67 Molecular medicine (Cambridge, Mass) Huang Y, Yu J, Wan F et al (2014) Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway [J]. Oxid Med Cell Longev, 2014: 978034 Sundaresan N R, Gupta M, Kim G et al (2009) Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice [J]. J Clin Invest 119(9):2758–2771 Wang B, Guo H, Li X et al (2018) Adiponectin attenuates oxygen-glucose Deprivation-Induced mitochondrial oxidative Injury and apoptosis in hippocampal HT22 cells via the JAK2/STAT3 pathway [J]. Cell Transpl 27(12):1731–1743 Moro MA, Almeida A, Bolanos J P et al (2005) Mitochondrial respiratory chain and free radical generation in Stroke [J]. Free Radic Biol Med 39(10):1291–1304 Yang K E, Jang H J, Hwang I H et al (2020) Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling [J]. J Ginseng Res 44(2):341–349 Song C, Zhao J, Fu B et al (2017) Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway [J]. Free Radic Biol Med 112:616–630 Ai Mamun A, Yu H (2018) Inflammatory responses are sex specific in chronic hypoxic-ischemic encephalopathy [J]. Cell Transpl 27(9):1328–1339 Mirza MA, Ritzel R, Xu Y et al (2015) Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy [J]. J Neuroinflammation 12:32 Ngwa C, Qi S, Mamun A A et al (2021) Age and sex differences in primary microglia culture: a comparative study [J]. J Neurosci Methods 364:109359 Qi S, Al Mamun A, Ngwa C et al (2021) X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals [J]. J Neuroinflammation 18(1):70