Gastric protection by misoprostol against 1300 mg of aspirin

Canadian Cooperative Study Group: A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 299:53?59, 1978

Persantine-Aspirin Reinfarction Study Research Group: Persantine and aspirin in coronary heart disease. Circulation 62:449?461, 1980

Plotz PH: Aspirin and salicylate.In Textbook of Rheumatology. WN Kelley, EO Harris (eds). Philadelphia, WB Saunders, 1981, pp 740?767

Erickson SH: Salicylic acid and related compounds.In Encyclopedia of Chemical Technology, 3rd ed, Vol 20. M Grayson, D Eckroth (eds) New York, John Wiley and Sons, 1982, p 520

Silvoso GR, Ivey KJ, Butt JH, Lockard SS, Holt DS, Sisk C, Baskin WN, Mackercher PA, Hewett J: Incidence of gastric lesions in patients with rheumatic disease on chronic aspirin therapy. Ann Intern Med 91:517?520, 1979

Thorsen Jr WB, Western D, Tanaka Y, Morrissey JF: Aspirin injury to the gastric mucosa: Gastrocamera observations of the effect of pH. Arch Intern Med 121:499?506, 1968

Hoftiezer JW, Silvoso GR, Burks M, Ivey KJ: Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa of man, Lancet 2:609?612, 1980

Kilander A, Dotevall G: Endoscopic evaluation of the comparative effects of acetylsalicylic acid and choline magnesium trisalicylate on human gastric and duodenal mucosa. Br J Rheumatol 22:36?40, 1983

Welch RW, Bentch HL, Harris SC: Reduction of aspirininduced gastrointestinal bleeding with cimetidine. Gastroenterology 74:459?463, 1978

Cohen MM, McCready DR, Clark L, Sevelius H: Protection against aspirin-induced antral and duodenal damage with enprostil. A double-blind endoscopic study. Gastroenterology 88:382?386, 1985

Silverstein FE, Saunders DR, Chapman RW, Levine DS: Cimetidine mucosal protection: A dose response study. Gastrointest Endosc 30:136, 1985

Konturek SJ, Kwiecien N, Obtulowicz W, Polanski M, Kopp B, Oleksy J: Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man. Gut 24:89?93, 1983

Gilbert DA, Surawicz CM, Silverstein FE, Weinberg CR, Saunders DR, Feld AD, Sanford RL, Bergman D, Washington P: Prevention of acute aspirin-induced gastric mucosal injury by 15-(R), 15-methyl prostaglandin E2: An endoscopic study. Gastroenterology 86:339?345, 1984

Muller P, Fischer N, Kather H, Simon B: Prevention of aspirin-induced drop in gastric potential difference with 16,16-dimethyl prostaglandin E2. Lancet 1:333?334, 1981

Cohen MM: Prevention of aspirin-induced fecal blood loss with oral prostaglandin E2. Dose-response studies in man. Prostaglandins 21(Suppl):155?169, 1981

O'Laughlin JC, Hoftiezer JW, Ivey KJ: Effect of aspirin on the human stomach in normals: Endoscopic comparison of damage produced one hour, 24 hours, and 2 weeks after administration. Scand J Gastroenterol 16(Suppl 67):211?214, 1981

Akdamar K, Ertan A, Agrawal NM, McMahon G, Ryan J, Kedia S, Burk J: Upper gastrointestinal endoscopy in normal asymptomatic volunteers. Am J Gastroenterol 78:670, 1983 (abstract)

Rosner BA: Fundamentals of Biostatistics. Boston, Duxbury Press, 1982, pp 210?214

Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761?767, 1979

Robert A, Nezamis JE, Lancaster C, Hanchar AJ Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77:433?443, 1979

Guth PH, Aures D, Paulsen G: Topical aspirin, plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Gastroenterology 76:88?93, 1979

Miller TA: Protective effects of prostaglandins against gastric mucosal damage: Current knowledge and proposed mechanisms. Am J Physiol 245:G601-G623 1983

Fung WP, Lea SK, Karim SMM: Effect of prostaglandin 15(R),15-methyl prostaglandin E2 methyl ester on the gastric mucosa in patients with peptic ulceration: An endoscopic and histological study. Prostaglandins 5:465?472, 1974

Bickel M Kauffman GL Jr: Gastric gel mucus thickness; Effect of distension, 16,16-dimethyl prostaglandin E2, and carbenoxolone. Gastroenterology 80:770?775, 1981

Kauffman GL Jr, Reeve JJ Jr, Grossman MI: Gastric bicarbonate secretion: effect of topical and intravenous 16,16-dimethyl prostaglandin E2. Am J Physiol 239:G44-G48, 1980

Cheung LY: Topical effects of 16,16-dimethyl prostaglandin E2 on gastric blood flow in dogs. Am J Physiol 238:G514-G519, 1980

Johansson C, Aly A, Kollberg B, Rubio C, Erikoinen T, Helander HF: Trophic actions of oral E2 prostaglandins on the rat gastrointestinal mucosa.In Advances in Prostaglandins, Thromboxane, and Leukotriene Research, Vol 12. B. Samuelsson, R Paoletti, P Ramwell (eds). New York, Raven, Press, 1983, pp 403?407

Schiessel R, Matthews J, Barzilai A, Merhav A, Silen W: PGE2 stimulates gastric chloride transport: Possible key to cytoprotection. Nature 283:671?673, 1980

Ferguson WW, Edmonds AW, Srarling JR, Wangensteen SL: Protective effect of prostaglandin E1 (PGE1) on lysosomal enzyme release in serotonin-induced gastric ulceration. Ann Surg 177:648?654, 1973

Lichtenberger LM, Richards JE, Hills BA: Effect of 16,16-dimethyl prostaglandin E2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. Gastroenterology 88:308?314, 1985

Cooke AR, Hunt JN: Absorption of acetylsalicylic acid from unbuffered and buffered gastric contents. Am J Dig Dis 15:95?102, 1970

Ivey KJ, Paone DB, Krause WJ: Acute effects of systemic aspirin on gastric mucosa in man. Dig Dis Sci 25:97?99, 1980

Akdamar K, Agrawal N, Ertan A: Inhibition of nocturnal gastric secretion in normal human volunteers by misoprostol: A synthetic prostaglandin E1 methyl ester analog. Am J Gastroenterol 77(12):902?904, 1982

Rajapaksa T, Adams A, Ramsamooj E, Quadros E, Wilson DE: The effects of an oral prostaglandin E1 (PGE1) analogue on gastric acid and mucous secretion in man. Clin Res 31:776A, 1983

Ene MD, Daneshmend TK, Roberts CJC: The effect of chronic dosing with cimetidine, carbenoxolone and SC-29333 on gastric acid output in man. Br J Clin Pharmacol 15:611?612, 1983

Hunt JN, Smith JL, Jiang CL, Kessler L: Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion. Dig Dis Sci 28:897?902, 1983

Cohen MM, Clark L, Armstrong L, D'Souza J: Reduced aspirin-induced fecal blood loss with simultaneous administration of misoprostol (PGE1 methyl analogue). Gastroenterology 84:1126, 1983 (abstract)

Graham DY, Lacey-Smith J, Dobbs SM: Gastric adaptation occurs with aspirin administration in man. Dig Dis Sci 28:1?6, 1983

Needham CD, Kyle J, Jones PF, Johnston SJ, Kerridge DF: Aspirin and alcohol in gastrointestinal hemorrhage Gut 12:819?821, 1971

Levy M: Aspirin use in patients with major upper gastrointestinal bleeding and peptic ulcer disease. N Engl J Med 290:1158?1162, 1974