Gabapentin: pharmacology and its use in pain management

Anaesthesia - Tập 57 Số 5 - Trang 451-462 - 2002
Michael Rose1, Peter Kam2
1Department of Anaesthesia and Pain Management, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia
2Associate Professor, Department of Anaesthesia and Pain Management, University of␣Sydney at Royal North Shore Hospital, St Leonards, NSW 2065, Australia

Tóm tắt

Summary Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage‐dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation. Gabapentin is especially effective at relieving allodynia and hyperalgesia in animal models. It has been shown to be efficacious in numerous small clinical studies and case reports in a wide variety of pain syndromes. Gabapentin has been clearly demonstrated to be effective for the treatment of neuropathic pain in diabetic neuropathy and postherpetic neuralgia. This evidence, combined with its favourable side‐effect profile in various patient groups (including the elderly) and lack of drug interactions, makes it an attractive agent. Therefore, gabapentin should be considered an important drug in the management of neuropathic pain syndromes.

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Anaesthesia

Tập 57 Số 5

451-462

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