GLP‐1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice

American Journal of Reproductive Immunology - Tập 74 Số 5 - Trang 457-466 - 2015
Erhong Zhang1, Fen Xu1, Hua Liang1, Jinhua Yan1, Haixia Xu1, Zhuo Li1, Xingqiao Wen1, Jianping Weng1
1Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Tóm tắt

Problem

Male obesity has been linked to subfecundity. This study is to investigate the effects of GLP‐1 receptor (GLP‐1R) agonist exenatide on sperm quality in high‐fat diet (HFD)‐induced obese mice.

Method of study

After 12 weeks of chow diet (CD) or HFD challenge, mice on HFD were allocated to either saline or exenatide (24 nmol/kg/day) interventions for 8 weeks. Sperm quality and the inflammatory profile of testis were compared among three groups.

Results

Obesity reduced the quality of sperm and changed the inflammatory profile characterized by increased mRNA expression levels of TNF‐α, MCP‐1, and F4/80 in testis. Exenatide intervention reduced the expression of pro‐inflammatory cytokines and improved the quality of sperm.

Conclusion

HFD‐induced obesity leads to the impairment of sperm quality and increased inflammation of testis in mice, and the abnormal physiology can be attenuated by exenatide treatment. Exenatide treatment may bring additional profits to obese and diabetes men by improving sperm function.

Từ khóa


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Thông tin
Thông tin xuất bản

American Journal of Reproductive Immunology

Tập 74 Số 5

457-466

Thông tin tác giả