GH effect on enzyme activity of 11βHSD in abdominal obesity is dependent on treatment duration

European Journal of Endocrinology - Tập 154 Số 1 - Trang 69-74 - 2006
Helga Ágústa Sigurjónsdóttir1, J. Korányi, Magnus Axelson, Bengt‐Åke Bengtsson, Gudmundur Johannsson
1Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.

Tóm tắt

Objective: In the past years the interaction of GH and 11βhydroxysteroid dehydrogenase (11βHSD) in the pathogenesis of central obesity has been suggested.

Design: We studied the effects of 9 months of GH treatment on 11βHSD activity and its relationship with body composition and insulin sensitivity in 30 men with abdominal obesity, aged 48–66 years, in a randomised, double-blind, placebo-controlled trial.

Methods: Urinary steroid profile was used to estimate 11βHSD type 1 and 2 (11βHSD1 and 11βHSD2) activities. Abdominal s.c. and visceral adipose tissues were measured using computed tomography. Glucose disposal rate (GDR) obtained during a euglycaemic–hyperinsulinaemic glucose clamp was used to assess insulin sensitivity.

Results: In the GH-treated group the 11βHSD1 activity decreased transiently after 6 weeks (P< 0.01) whereas 11βHSD2 increased after 9 months of treatment (P< 0.05). Between 6 weeks and 9 months, GDR increased and visceral fat mass decreased. Changes in 11βHSD1 correlated with changes in visceral fat mass between baseline and 6 weeks. There were no significant correlations between 11βHSD1 and 11βHSD 2 and changes in GDR.

Discussion: The study demonstrates that short- and long-term GH treatment has different effects on 11βHSD1 and 11βHSD2 activity. Moreover, the data do not support that long-term metabolic effects of GH are mediated through its action on 11βHSD.

Từ khóa


Tài liệu tham khảo

Tannin, 1991, Journal of Biological Chemistry, 266, 16653, 10.1016/S0021-9258(18)55351-5

Yang, 1997, The Journal of steroid biochemistry and molecular biology, 60, 247, 10.1016/S0960-0760(96)00187-2

Bujalska, 1997, Lancet, 349, 1210, 10.1016/S0140-6736(96)11222-8

Katz, 1999, Clinical endocrinology, 50, 63, 10.1046/j.1365-2265.1999.00598.x

Walker, 1992, Endocrinology, 131, 970, 10.1210/en.131.2.970

Donovan, 1999, British journal of biomedical science, 56, 215

Sigurjonsdottir, 2003, Journal of human hypertension, 17, 125, 10.1038/sj.jhh.1001504

1998, Cardiovascular Research, 38, 16, 10.1016/S0008-6363(97)00299-X

Andrew, 1998, Journal of Clinical Endocrinology &amp; Metabolism, 83, 1806, 10.1210/jc.83.5.1806

Andrews, 2002, Journal of Clinical Endocrinology &amp; Metabolism, 87, 5587, 10.1210/jc.2002-020048

Rask, 2002, Journal of Clinical Endocrinology &amp; Metabolism, 87, 3330, 10.1210/jc.87.7.3330

Tomlinson, 2002, Journal of Clinical Endocrinology &amp; Metabolism, 87, 5630, 10.1210/jc.2002-020687

Weaver, 1994, Clinical endocrinology, 41, 639, 10.1111/j.1365-2265.1994.tb01830.x

Gelding, 1998, Clinical endocrinology, 48, 153, 10.1046/j.1365-2265.1998.3641180.x

Moore, 1999, Journal of Clinical Endocrinology &amp; Metabolism, 84, 4172, 10.1210/jc.84.11.4172

Liu, 1996, Life sciences, 59, 227, 10.1016/0024-3205(96)00288-3

Toogood, 2000, Journal of Clinical Endocrinology &amp; Metabolism, 85, 1727, 10.1210/jc.85.4.1727

Walker, 1998, Clinical endocrinology, 49, 257, 10.1046/j.1365-2265.1998.00575.x

Dullaart, 1995, Journal of Clinical Endocrinology &amp; Metabolism, 80, 3002, 10.1210/jc.80.10.3002

Kerstens, 2000, Clinical endocrinology, 52, 403, 10.1046/j.1365-2265.2000.00975.x

Johannsson, 1997, Journal of Clinical Endocrinology &amp; Metabolism, 82, 727, 10.1210/jc.82.3.727

1981, JOURNAL OF CHROMATOGRAPHY A, 224, 355, 10.1016/S0378-4347(00)80208-X

Best, 1997, Clinical endocrinology, 47, 231, 10.1046/j.1365-2265.1997.2471061.x

Palermo, 1996, Clinical endocrinology, 45, 605, 10.1046/j.1365-2265.1996.00853.x

Stewart, 1999, Journal of Clinical Endocrinology &amp; Metabolism, 84, 1022, 10.1210/jc.84.3.1022

Westerbacka, 2003, Journal of Clinical Endocrinology &amp; Metabolism, 88, 4924, 10.1210/jc.2003-030596

Wake, 2003, Journal of Clinical Endocrinology &amp; Metabolism, 88, 3983, 10.1210/jc.2003-030286

Trainer, 2001, Journal of Clinical Endocrinology &amp; Metabolism, 86, 2989, 10.1210/jc.86.7.2989

Isidori, 2003, Clinical endocrinology, 58, 601, 10.1046/j.1365-2265.2003.01759.x

Rodr  guez-Arnao, 1996, Clinical endocrinology, 45, 33, 10.1111/j.1365-2265.1996.tb02057.x

Tomlinson, 2003, Journal of Clinical Endocrinology &amp; Metabolism, 88, 2113, 10.1210/jc.2002-021894

Thông tin
Thông tin xuất bản

European Journal of Endocrinology

Tập 154 Số 1

69-74

Thông tin tác giả