Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

American Association for the Advancement of Science (AAAS) - Tập 243 Số 4890 - Trang 500-507 - 1989
Yusuf A. Hannun1, Robert M. Bell
1Department of Medicine, Duke University Medical Center, Durham, NC 27710.

Tóm tắt

The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction. Sphingolipids and lysosphingolipids affect significant cellular responses and exhibit antitumor promoter activities in various mammalian cells. These molecules may function as endogenous modulators of cell function and possibly as second messengers.

Từ khóa


Tài liệu tham khảo

BELL, R.M., PROTEIN-KINASE-C ACTIVATION BY DIACYLGLYCEROL 2ND MESSENGERS, CELL 45: 631 (1986).

BERRIDGE, M.J., INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL AS 2ND MESSENGERS, BIOCHEMICAL JOURNAL 220: 345 (1984).

BISHOP, W.R., FUNCTIONS OF DIACYLGLYCEROL IN GLYCEROLIPID METABOLISM, SIGNAL TRANSDUCTION AND CELLULAR-TRANSFORMATION, ONCOGENE RESEARCH 2: 205 (1988).

BLACKBURN, C.C., GANGLIOSIDES SUPPORT NEURAL RETINA CELL-ADHESION, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 2873 (1986).

BOCCKINO, S.B., PHOSPHATIDATE ACCUMULATION IN HORMONE-TREATED HEPATOCYTES VIA A PHOSPHOLIPASE-D MECHANISM, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 15309 (1987).

BREMER, E.G., GANGLIOSIDE-MEDIATED MODULATION OF CELL-GROWTH, GROWTH-FACTOR BINDING, AND RECEPTOR PHOSPHORYLATION, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 6818 (1984).

BREMER, E.G., GANGLIOSIDE-MEDIATED MODULATION OF CELL-GROWTH - SPECIFIC EFFECTS OF GM3 ON TYROSINE PHOSPHORYLATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 2434 (1986).

BYRNE, M.C., GANGLIOSIDE-INDUCED NEURITOGENESIS - VERIFICATION THAT GANGLIOSIDES ARE THE ACTIVE AGENTS, AND COMPARISON OF MOLECULAR-SPECIES, JOURNAL OF NEUROCHEMISTRY 41: 1214 (1983).

CABOT, M.C., STRUCTURAL AND CHEMICAL SPECIFICITY OF DIRADYLGLYCEROLS FOR PROTEIN KINASE-C ACTIVATION, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 125: 163 (1984).

CASTAGNA, M, DIRECT ACTIVATION OF CALCIUM-ACTIVATED, PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE BY TUMOR-PROMOTING PHORBOL ESTERS, JOURNAL OF BIOLOGICAL CHEMISTRY 257: 7847 (1982).

CHAN, KFJ, GANGLIOSIDE-MODULATED PROTEIN-PHOSPHORYLATION - PARTIAL-PURIFICATION AND CHARACTERIZATION OF A GANGLIOSIDE-INHIBITED PROTEIN-KINASE IN BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 568 (1988).

CHAN, KFJ, GANGLIOSIDE-MODULATED PROTEIN-PHOSPHORYLATION IN MYELIN, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 2415 (1987).

CHAN, KFJ, GANGLIOSIDE-MODULATED PROTEIN-PHOSPHORYLATION - PARTIAL-PURIFICATION AND CHARACTERIZATION OF A GANGLIOSIDE-STIMULATED PROTEIN-KINASE IN BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 5248 (1987).

CIVAN, M.M., INSULIN AND PHORBOL ESTER STIMULATE CONDUCTIVE NA+ TRANSPORT THROUGH A COMMON PATHWAY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 963 (1988).

CLELAND, W.W., ENZYMATIC SYNTHESIS OF PSYCHOSINE, JOURNAL OF BIOLOGICAL CHEMISTRY 235: 45 (1960).

CONKLING P unpublished data.

10.1126/science.2452481

COULONMORELEC, M.J., LIPID PATTERNS OF EMBRYONAL CARCINOMA CELL-LINES AND THEIR DERIVATIVES - CHANGES WITH DIFFERENTIATION, DEVELOPMENTAL BIOLOGY 83: 278 (1981).

10.1126/science.3755548

CURTINO, J.A., ENZYMATIC-SYNTHESIS OF GLUCOSYLSPHINGOSINE BY RAT-BRAIN MICROSOMES, LIPIDS 7: 525 (1972).

DAVIS, R.J., 2 ALTERNATIVE MECHANISMS CONTROL THE INTERCONVERSION OF FUNCTIONAL-STATES OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 5373 (1988).

DAVIS, R.J., STRUCTURAL REQUIREMENTS FOR DIACYLGLYCEROLS TO MIMIC TUMOR-PROMOTING PHOBOL DIESTER ACTION ON THE EPIDERMAL GROWTH-FACTOR RECEPTOR, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 5315 (1985).

DIPPOLD, W.G., INHIBITION OF HUMAN-MELANOMA CELL-GROWTH INVITRO BY MONOCLONAL ANTI-GD3-GANGLIOSIDE ANTIBODY, CANCER RESEARCH 44: 806 (1984).

ETO, Y, SULFOGALACTOSYLSPHINGOSINE SULFATASE - CHARACTERISTICS OF ENZYME AND ITS DEFICIENCY IN METACHROMATIC LEUKODYSTROPHY IN HUMAN CULTURED SKIN FIBROBLASTS, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 4955 (1974).

FARRELL, D.F., CHARACTERIZATION OF CEREBROSIDE SULFOTRANSFERASE FROM RAT BRAIN, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 4694 (1971).

FAUCHER, M, REGULATION OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR PHOSPHORYLATION STATE BY SPHINGOSINE IN A431 HUMAN EPIDERMOID CARCINOMA-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 5319 (1988).

FEIZI, T, 3 TYPES OF BLOOD GROUP-I SPECIFICITY AMONG MONOCLONAL ANTI-I AUTOANTIBODIES REVEALED BY ANALOGS OF A BRANCHED ERYTHROCYTE GLYCOLIPID, JOURNAL OF EXPERIMENTAL MEDICINE 149: 975 (1979).

FISHER, G.J., SPHINGOSINE INHIBITS PHORBOL ESTER-INDUCED INFLAMMATION, ORNITHINE DECARBOXYLASE ACTIVITY AND ACTIVATION OF PROTEIN-KINASE C IN MOUSE SKIN, FASEB JOURNAL 2: A350 (1988).

FISHMAN, P.H., ROLE OF MEMBRANE GANGLIOSIDES IN THE BINDING AND ACTION OF BACTERIAL TOXINS, JOURNAL OF MEMBRANE BIOLOGY 69: 85 (1982).

10.1126/science.183.4124.540

FUKUDA, M.N., STRUCTURE OF A NOVEL SIALYLATED FUCOSYL LACTO-N-NOR-HEXAOSYLCERAMIDE ISOLATED FROM CHRONIC MYELOGENOUS LEUKEMIA-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 2376 (1986).

GAHMBERG, C.G., SURFACE CARBOHYDRATES OF HAMSTER FIBROBLASTS .1. CHEMICAL CHARACTERIZATION OF SURFACE-LABELED GLYCOSPHINGOLIPIDS AND A SPECIFIC CERAMIDE TETRASACCHARIDE FOR TRANSFORMANTS, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 2438 (1975).

GANONG, B.R., SPECIFICITY AND MECHANISM OF PROTEIN-KINASE-C ACTIVATION BY SN-1,2-DIACYLGLYCEROLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 1184 (1986).

GLICKMAN, R.M., CHARACTERIZATION, DISTRIBUTION AND BIOSYNTHESIS OF MAJOR GANGLIOSIDE OF RAT INTESTINAL-MUCOSA, BIOCHIMICA ET BIOPHYSICA ACTA 424: 17 (1976).

GOLDENRING, J.R., CALCIUM GANGLIOSIDE-DEPENDENT PROTEIN-KINASE ACTIVITY IN RAT-BRAIN MEMBRANE, JOURNAL OF NEUROCHEMISTRY 44: 1229 (1985).

GROVE, D.S., PREVENTION OF THE TPA-MEDIATED DOWN-REGULATION OF PROTEIN KINASE-C, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 151: 94 (1988).

HAKOMORI, S, GLYCOSPHINGOLIPIDS, SCIENTIFIC AMERICAN 254: 44 (1986).

HAKOMORI, S, SPHINGOLIPID BIOCH: 327 (1983).

HAKOMORI, S, SPHINGOLIPID BIOCH: 381 (1983).

HAKOMORI, S.I., CELL DENSITY-DEPENDENT CHANGES OF GLYCOLIPID CONCENTRATIONS IN FIBROBLASTS, AND LOSS OF THIS RESPONSE IN VIRUS-TRANSFORMED CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 67: 1741 (1970).

HAKOMORI, S.I., SPHINGOLIPID BIOCH: 1 (1983).

HALL, F.L., SUPPRESSION OF NERVE GROWTH FACTOR-DIRECTED NEURITE OUTGROWTH IN PC12 CELLS BY SPHINGOSINE, AN INHIBITOR OF PROTEIN KINASE-C, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 4460 (1988).

HANAI, N, MODIFIED GANGLIOSIDE AS A POSSIBLE MODULATOR OF TRANSMEMBRANE SIGNALING MECHANISM THROUGH GROWTH-FACTOR RECEPTORS - A PRELIMINARY NOTE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 147: 127 (1987).

HANNUN, Y, J BIOL CHEM 260: 15718 (1985).

HANNUN, Y, J BIOL CHEM 263: 15241 (1988).

HANNUN Y unpublished data.

HANNUN, Y.A., ACTIVATION OF PROTEIN KINASE-C BY TRITON X-100 MIXED MICELLES CONTAINING DIACYLGLYCEROL AND PHOSPHATIDYLSERINE, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 10039 (1985).

HANNUN, Y.A., SPHINGOSINE INHIBITION OF PROTEIN-KINASE-C ACTIVITY AND OF PHORBOL DIBUTYRATE BINDING INVITRO AND IN HUMAN-PLATELETS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12604 (1986).

HANNUN, Y.A., PROTEIN-KINASE-C ACTIVATION IN MIXED MICELLES - MECHANISTIC IMPLICATIONS OF PHOSPHOLIPID, DIACYLGLYCEROL, AND CALCIUM INTERDEPENDENCIES, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 7184 (1986).

HANNUN, Y.A., PHORBOL ESTER BINDING AND ACTIVATION OF PROTEIN-KINASE-C ON TRITON X-100 MIXED MICELLES CONTAINING PHOSPHATIDYLSERINE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 9341 (1986).

HANNUN, Y.A., SPHINGOSINE INHIBITION OF AGONIST-DEPENDENT SECRETION AND ACTIVATION OF HUMAN-PLATELETS IMPLIES THAT PROTEIN-KINASE-C IS A NECESSARY AND COMMON EVENT OF THE SIGNAL TRANSDUCTION PATHWAYS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 13620 (1987).

10.1126/science.3101176

10.1126/science.125.3256.1041

HELLSTROM, I, STRONG ANTITUMOR ACTIVITIES OF IGG3 ANTIBODIES TO A HUMAN MELANOMA-ASSOCIATED GANGLIOSIDE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 1499 (1985).

HILDEBRAND, J, BIOSYNTHESIS OF LACTOSYLCERAMIDE BY RAT BRAIN PREPARATIONS AND COMPARISON WITH FORMATION OF GANGLIOSIDE GM1 AND PSYCHOSINE DURING DEVELOPMENT, JOURNAL OF NEUROCHEMISTRY 17: 403 (1970).

HIRSCH, H.E., SEROLOGICAL REACTIONS AGAINST GLYCOLIPID-SENSITIZED LIPOSOMES IN MULTIPLE-SCLEROSIS, NATURE 264: 785 (1976).

HOKIN, M.R., ENZYME SECRETION AND THE INCORPORATION OF P-82 INTO PHOSPHOLIPIDES OF PANCREAS SLICES, JOURNAL OF BIOLOGICAL CHEMISTRY 203: 967 (1953).

HONSIK, C.J., LYMPHOKINE-ACTIVATED KILLER-CELLS TARGETED BY MONOCLONAL-ANTIBODIES TO THE DISIALOGANGLIOSIDES GD2 AND GD3 SPECIFICALLY LYSE HUMAN-TUMOR CELLS OF NEUROECTODERMAL ORIGIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 7893 (1986).

10.1126/science.3278379

HUANG, K.P., AUTOPHOSPHORYLATION OF RAT-BRAIN CA-2+-ACTIVATED AND PHOSPHOLIPID-DEPENDENT PROTEIN-KINASE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 2134 (1986).

IGISU, H, ANALYSIS OF GALACTOSYLSPHINGOSINE (PSYCHOSINE) IN THE BRAIN, JOURNAL OF LIPID RESEARCH 25: 1000 (1984).

10.1126/science.6719111

JOZWIAK, W, LACTOSYLSPHINGOSINE-REACTIVE ANTIBODY AND CEA IN PATIENTS WITH COLORECTAL-CANCER, EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY 18: 617 (1982).

Kato, M., Journal of Biological Chemistry 262: 5696 (1987).

KATOHSEMBA, R, GANGLIOSIDES STIMULATE ASTROGLIAL CELL-PROLIFERATION IN THE ABSENCE OF SERUM, JOURNAL OF CELLULAR PHYSIOLOGY 126: 147 (1986).

KAWAI, G, STIMULATORY EFFECT OF CERTAIN PLANT SPHINGOLIPIDS ON FRUITING OF SCHIZOPHYLLUM-COMMUNE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 779 (1986).

KEENAN, R.W., IN VITRO DEGRADATION OF DIHYDROSPHINGOSINE, BIOCHIMICA ET BIOPHYSICA ACTA 176: 348 (1969).

KEENAN, T.W., EXOGENOUS GLYCOSPHINGOLIPIDS SUPPRESS GROWTH-RATE OF TRANSFORMED AND UNTRANSFORMED 3T3 MOUSE CELLS, EXPERIMENTAL CELL RESEARCH 92: 259 (1975).

KNOPF, J.L., CLONING AND EXPRESSION OF MULTIPLE PROTEIN-KINASE-C CDNAS, CELL 46: 491 (1986).

KOLESNICK, R.N., 1,2-DIACYGLYCEROLS BUT NOT PHORBOL ESTERS STIMULATE SPHINGOMYELIN HYDROLYSIS IN GH3 PITUITARY-CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 16759 (1987).

KONDOH, H, DEACYLATION OF CERAMIDE, TRIACYLGLYCEROL AND PHOSPHOLIPIDS IN GUINEA-PIG EPIDERMAL-CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 753: 97 (1983).

KREUTTER, D, REGULATION OF PROTEIN-KINASE-C ACTIVITY BY GANGLIOSIDES, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 1633 (1987).

LAINE, R.A., INCORPORATION OF EXOGENOUS GLYCOSPHINGOLIPIDS IN PLASMA-MEMBRANES OF CULTURED HAMSTER CELLS AND CONCURRENT CHANGE OF GROWTH BEHAVIOR, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 54: 1039 (1973).

LAMARCO, K.L., GALACTOSYLSPHINGOSINE INHIBITION OF THE BROAD-SPECIFICITY CYTOSOLIC BETA-GLUCOSIDASE OF HUMAN-LIVER, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 236: 669 (1985).

LAMBETH, J.D., SPHINGANINE EFFECTS ON CHEMOATTRACTANT-INDUCED DIACYLGLYCEROL GENERATION, CALCIUM FLUXES, SUPEROXIDE PRODUCTION, AND ON CELL VIABILITY IN THE HUMAN NEUTROPHIL - DELIVERY OF SPHINGANINE WITH BOVINE SERUM-ALBUMIN MINIMIZES CYTO-TOXICITY WITHOUT AFFECTING INHIBITION OF THE RESPIRATORY BURST, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 3818 (1988).

LARRAGA, V, IMMUNOCHEMICAL CHARACTERIZATION OF SURFACE-ANTIGENS OF TERC, A TERATOCARCINOMA-DERIVED CELL-LINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 2912 (1979).

LEDEEN, R.W., BIOLOGY OF GANGLIOSIDES - NEURITOGENIC AND NEURONOTROPHIC PROPERTIES, JOURNAL OF NEUROSCIENCE RESEARCH 12: 147 (1984).

LEVINE, P, SPECIFICITY OF ANTIBODY IN PAROXYSMAL COLD HEMOGLOBINURIA (PCH), ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 124: 456 (1965).

LINGWOOD, C.A., SELECTIVE-INHIBITION OF CELL-GROWTH AND ASSOCIATED CHANGES IN GLYCOLIPID METABOLISM INDUCED BY MONOVALENT ANTIBODIES TO GLYCOLIPIDS, EXPERIMENTAL CELL RESEARCH 108: 385 (1977).

LIVINGSTON, P.O., VACCINES CONTAINING PURIFIED GM2 GANGLIOSIDE ELICIT GM2 ANTIBODIES IN MELANOMA PATIENTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 2911 (1987).

LOCKNEY, M.W., PHORBOL ESTER TUMOR PROMOTERS SPECIFICALLY STIMULATE CHOLINE PHOSPHOLIPID-METABOLISM IN HUMAN-LEUKEMIC CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 796: 384 (1984).

10.1126/science.3276003

Majerus, P. W., Journal of Biological Chemistry 263: 3051 (1988).

MAKITA, A, GLYCOLIPIDS: 1 (1985).

MANDEL, P, ADV EXP MED BIOL 125: 515 (1980).

MARCHASE, R.B., BIOCHEMICAL INVESTIGATIONS OF RETINOTECTAL ADHESIVE SPECIFICITY, JOURNAL OF CELL BIOLOGY 75: 237 (1977).

MARCUS, D.M., A REVIEW OF THE IMMUNOGENIC AND IMMUNO-MODULATORY PROPERTIES OF GLYCOSPHINGOLIPIDS, MOLECULAR IMMUNOLOGY 21: 1083 (1984).

10.1126/science.164.3879.553

MARKUS, D, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 3263 (1976).

MATYAS, G.R., ALTERATION OF GLYCOLIPIDS IN RAS-TRANSFECTED NIH-3T3 CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 6065 (1987).

MCINTYRE, T.M., PROTEIN-KINASE-C ACTIVITY APPEARS TO BE REQUIRED FOR THE SYNTHESIS OF PLATELET-ACTIVATING-FACTOR AND LEUKOTRIENE-B4 BY HUMAN-NEUTROPHILS, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 15370 (1987).

MERRILL, A.H., CHARACTERIZATION OF SERINE PALMITOYLTRANSFERASE ACTIVITY IN CHINESE-HAMSTER OVARY CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 754: 284 (1983).

MERRILL, A.H., INHIBITION OF PHORBOL ESTER-DEPENDENT DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIC (HL-60) CELLS BY SPHINGANINE AND OTHER LONG-CHAIN BASES, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12610 (1986).

MERRILL A.H. unpublished data.

MIYATAKE, T, GLOBOID CELL LEUKODYSTROPHY - ADDITIONAL DEFICIENCY OF PSYCHOSINE GALACTOSIDASE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 48: 538 (1972).

MIYATAKE, T, GALACTOSYLSPHINGOSINE GALACTOSYL HYDROLASE IN RAT-BRAIN - PROBABLE IDENTITY WITH GALACTOSYLCERAMIDE GALACTOSYL HYDROLASE, JOURNAL OF NEUROCHEMISTRY 22: 231 (1974).

MOMOI, T, ACTIVATION OF CMP-N-ACETYLNEURAMINIC ACID - LACTOSYLCERAMIDE SIALYLTRANSFERASE DURING THE DIFFERENTIATION OF HL-60 CELLS INDUCED BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 16270 (1986).

MOOLENAAR, W.H., GROWTH FACTOR-LIKE ACTION OF PHOSPHATIDIC-ACID, NATURE 323: 171 (1986).

MOSKAL, J.R., CHANGES IN GLYCOLIPID GLYCOSYLTRANSFERASES AND GLUTAMATE DECARBOXYLASE AND THEIR RELATIONSHIP TO DIFFERENTIATION IN NEUROBLASTOMA-CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 61: 751 (1974).

NAGAI, Y, GANGLIOSIDE SYNDROME, A NEW AUTOIMMUNE NEUROLOGIC DISORDER, EXPERIMENTALLY INDUCED WITH BRAIN GANGLIOSIDES, NEUROSCIENCE LETTERS 2: 107 (1976).

NEEDLEMAN, P, ARACHIDONIC-ACID METABOLISM, ANNUAL REVIEW OF BIOCHEMISTRY 55: 69 (1986).

NELSON, D.H., DEXAMETHASONE INCREASES TISSUE SPHINGOSINE LEVELS AND BLOCKS PHORBOL STIMULATED GLUCOSE-TRANSPORT, FASEB JOURNAL 2: A1417 (1988).

NELSON, D.H., SPHINGOLIPIDS INHIBIT INSULIN AND PHORBOL ESTER STIMULATED UPTAKE OF 2-DEOXYGLUCOSE, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 138: 463 (1986).

NELSON, D.H., DEXAMETHASONE-INDUCED CHANGE IN THE SPHINGOMYELIN CONTENT OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES INVITRO, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 54: 292 (1982).

Nelson, D. H., Proceedings of the National Academy of Sciences of the United States of America 79: 6690 (1982).

NEUENHOFER, S, OCCURRENCE OF LYSOGANGLIOSIDE LYSO-GM2 (II3-NEU5AC-GANGLIOTRIAOSYLSPHINGOSINE) IN GM2 GANGLIOSIDOSIS BRAIN, BIOLOGICAL CHEMISTRY HOPPE-SEYLER 367: 241 (1986).

Niedel, J. E., Proceedings of the National Academy of Sciences of the United States of America 80: 36 (1983).

NILLSON, O, J NEUROCHEM 39: 709 (1982).

NILLISON, O, BIOCHIM BIOPHYS ACTA 712: 453 (1982).

NILSSON, O, GLYCOSPHINGOLIPID STUDIES OF VISCERAL TISSUES AND BRAIN FROM TYPE-1 GAUCHER DISEASE VARIANTS, CLINICAL GENETICS 27: 443 (1985).

NINIO, E, ENZYMES LIPID METABO: 191 (1986).

10.1126/science.3014651

NOJIRI, H, GANGLIOSIDE-GM3 - AN ACIDIC MEMBRANE COMPONENT THAT INCREASES DURING MACROPHAGE-LIKE CELL-DIFFERENTIATION CAN INDUCE MONOCYTIC DIFFERENTIATION OF HUMAN MYELOID AND MONOCYTOID LEUKEMIC-CELL LINES HL-60 AND U937, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 782 (1986).

NUSSBAUM, J.L., ENZYMIC-SYNTHESIS OF PSYCHOSINE SULFATE, JOURNAL OF NEUROCHEMISTRY 19: 1789 (1972).

OBATA, K, EFFECTS OF GLYCOLIPIDS ON INVITRO DEVELOPMENT OF NEUROMUSCULAR-JUNCTION, NATURE 266: 369 (1977).

OKUYAMA, E, CHEMICAL AND PHARMACEUTICAL BULLETIN 31: 2269 (1983).

ONO, Y, CLONING OF RAT-BRAIN PROTEIN-KINASE-C COMPLEMENTARY-DNA, FEBS LETTERS 203: 111 (1986).

ONO, Y, IDENTIFICATION OF 3 ADDITIONAL MEMBERS OF RAT PROTEIN-KINASE C FAMILY - DELTA-SUBSPECIE,EPSILON-SUBSPECIE AND ZETA-SUBSPECIE, FEBS LETTERS 226: 125 (1987).

10.1126/science.3755547

PITTET, D.I., J BIOL CHEM 263: 10072 (1987).

PREISS, J, QUANTITATIVE MEASUREMENT OF SN-1,2-DIACYLGLYCEROLS PRESENT IN PLATELETS, HEPATOCYTES, AND RAS-TRANSFORMED AND SIS-TRANSFORMED NORMAL RAT-KIDNEY CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 8597 (1986).

RAMACHANDRAN, C, INCREASED ACTIVITY OF NEUTRAL SPHINGOMYELINASE IN DEXAMETHASONE TREATED 3T3-L1 CELLS, FASEB JOURNAL 2: A581 (1988).

RANDO, R.R., THE STEREOSPECIFIC ACTIVATION OF PROTEIN KINASE-C, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 122: 818 (1984).

ROBB, R.J., THE SUPPRESSIVE EFFECT OF GANGLIOSIDES UPON IL 2-DEPENDENT PROLIFERATION AS A FUNCTION OF INHIBITION OF IL 2-RECEPTOR ASSOCIATION, JOURNAL OF IMMUNOLOGY 136: 971 (1986).

ROBERTS, D.D., VONWILLEBRAND-FACTOR BINDS SPECIFICALLY TO SULFATED GLYCOLIPIDS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 3306 (1986).

ROBERTS, D.D., COMPARISON OF THE SPECIFICITIES OF LAMININ, THROMBOSPONDIN, AND VONWILLEBRAND-FACTOR FOR BINDING TO SULFATED GLYCOLIPIDS, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 6872 (1986).

SAKIYAMA, H, GLYCOLIPID SYNTHESIS IN NORMAL AND VIRUS-TRANSFORMED HAMSTER CELL LINES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 872 (1972).

10.1126/science.2820055

SCHWARTING, G.A., GANGLIOTETRAOSYLCERAMIDE IS A T-CELL DIFFERENTIATION ANTIGEN ASSOCIATED WITH NATURAL CELL-MEDIATED CYTO-TOXICITY, JOURNAL OF IMMUNOLOGY 124: 1691 (1980).

SHARKEY, N.A., KINETIC EVIDENCE THAT 1,2-DIOLEIN INHIBITS PHORBOL ESTER BINDING TO PROTEIN-KINASE-C VIA A COMPETITIVE MECHANISM, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 133: 1051 (1985).

SHAROM, F.J., GLYCOSPHINGOLIPIDS IN MEMBRANE ARCHITECTURE, JOURNAL OF SUPRAMOLECULAR STRUCTURE 6: 249 (1977).

SHINODA, H, ACCUMULATION OF GALACTOSYLSPHINGOSINE (PSYCHOSINE) IN THE TWITCHER MOUSE - DETERMINATION BY HPLC, JOURNAL OF NEUROCHEMISTRY 49: 92 (1987).

SIFFERT, W, PROTEIN KINASE-C ENHANCES CA-2+ MOBILIZATION IN HUMAN-PLATELETS BY ACTIVATING NA+/H+ EXCHANGE, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 4223 (1988).

SPEIZER, L. A., FEDERATION PROCEEDINGS 46: 2065 (1987).

Spiegel, S., Journal of Biological Chemistry 261: 15755 (1986).

SPIEGEL, S, GANGLIOSIDES AS BIMODAL REGULATORS OF CELL-GROWTH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 141 (1987).

10.1126/science.2999979

STOFFEL, W, Z PHYSL CHEM 354: 562 (1973).

Suzuki, K., Current Trends in Sphingolipidoses and Allied Disorders: 99 (1976).

SYMINGTON, F.W., INTRACELLULAR-LOCALIZATION OF LACTOSYLCERAMIDE, THE MAJOR HUMAN NEUTROPHIL GLYCOSPHINGOLIPID, JOURNAL OF BIOLOGICAL CHEMISTRY 262: 11356 (1987).

TAKETOMI, T, PHYSIOLOGICAL ACTIVITY OF PSYCHOSINE, JAPANESE JOURNAL OF EXPERIMENTAL MEDICINE 34: 255 (1964).

TAKI, T, A GANGLIOSIDE OF RAT ASCITES HEPATOMA AH-7974F CELLS - OCCURRENCE OF A NOVEL DISIALOGANGLIOSIDE (GD1ALPHA) WITH A UNIQUE N-ACETYLNEURAMINOSYL(ALPHA2-6)-N-ACETYLGALACTOSAMINE STRUCTURE, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 3075 (1986).

THOMPSON, L.K., LOCALIZATION OF THE GANGLIOSIDE-BINDING SITE OF FIBRONECTIN, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 5209 (1986).

THURIN, J, GD2 GANGLIOSIDE BIOSYNTHESIS IS A DISTINCT BIOCHEMICAL EVENT IN HUMAN-MELANOMA TUMOR PROGRESSION, FEBS LETTERS 208: 17 (1986).

TSUJI, S, GQ1B, A BIOACTIVE GANGLIOSIDE THAT EXHIBITS NOVEL NERVE GROWTH-FACTOR (NGF)-LIKE ACTIVITIES IN THE 2 NEURO-BLASTOMA CELL-LINES, JOURNAL OF BIOCHEMISTRY 94: 303 (1983).

TSUJI, S, BIOACTIVE GANGLIOSIDES .4. GANGLIOSIDE GQ1B/CA-2+ DEPENDENT PROTEIN-KINASE ACTIVITY EXISTS IN THE PLASMA-MEMBRANE FRACTION OF NEURO-BLASTOMA CELL-LINE, GOTO, JOURNAL OF BIOCHEMISTRY 97: 969 (1985).

USUKI, S, SIALIDASE ACTIVITIES OF CULTURED HUMAN-FIBROBLASTS AND THE METABOLISM OF GM3 GANGLIOSIDE, JOURNAL OF BIOLOGICAL CHEMISTRY 263: 6847 (1988).

VACCARINO, F, GANGLIOSIDE INHIBITION OF GLUTAMATE-MEDIATED PROTEIN-KINASE-C TRANSLOCATION IN PRIMARY CULTURES OF CEREBELLAR NEURONS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 8707 (1987).

VANBLITTERSWIJK, W.J., MEMBRANE FLUIDITY BI 3: 85 (1985).

VANHEYNINGEN, W.E., THE FIXATION OF TETANUS TOXIN BY NERVOUS TISSUE, JOURNAL OF GENERAL MICROBIOLOGY 20: 291 (1959).

VANIER, M.T., CHEMICAL PATHOLOGY OF KRABBES DISEASE .3. CERAMIDE-HEXOSIDES AND GANGLIOSIDES OF BRAIN, ACTA PAEDIATRICA SCANDINAVICA 64: 641 (1975).

WATANABE, K, CHARACTERIZATION OF A BLOOD-GROUP I-ACTIVE GANGLIOSIDE - STRUCTURAL REQUIREMENTS FOR I AND I SPECIFICITIES, JOURNAL OF BIOLOGICAL CHEMISTRY 254: 3221 (1979).

WENZL, S, A NOVEL GLYCOSPHINGOLIPID THAT MAY PARTICIPATE IN EMBRYO INVERSION IN VOLVOX CARTERI, CELL 46: 633 (1986).

WHATLEY, R, DEVELOPMENTAL-CHANGES IN GANGLIOSIDES DURING MYOGENESIS OF A RAT MYOBLAST CELL LINE AND ITS DRUG-RESISTANT VARIANTS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 70: 180 (1976).

WIEGANDT, H, GLYCOLIPIDS: 199 (1985).

WILSON, E, PROTEIN-KINASE-C INHIBITION BY SPHINGOID LONG-CHAIN BASES - EFFECTS ON SECRETION IN HUMAN-NEUTROPHILS, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 259: 204 (1987).

Wilson, E., Journal of Biological Chemistry 263: 9304 (1988).

WILSON, E, INHIBITION OF THE OXIDATIVE BURST IN HUMAN-NEUTROPHILS BY SPHINGOID LONG-CHAIN BASES - ROLE OF PROTEIN-KINASE-C IN ACTIVATION OF THE BURST, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 12616 (1986).