Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans

Wiley - Tập 56 Số 2 - Trang 178-197 - 2003
Ephraim L. Tsalik1, Oliver Hobert2
1Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
2Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032

Tóm tắt

Abstract

One approach to understanding behavior is to define the cellular components of neuronal circuits that control behavior. In the nematode Caenorhabditis elegans, neuronal circuits have been delineated based on patterns of synaptic connectivity derived from ultrastructural analysis. Individual cellular components of these anatomically defined circuits have previously been characterized on the sensory and motor neuron levels. In contrast, interneuron function has only been addressed to a limited extent. We describe here several classes of interneurons (AIY, AIZ, and RIB) that modulate locomotory behavior in C. elegans. Using mutant analysis as well as microsurgical mapping techniques, we found that the AIY neuron class serves to tonically modulate reversal frequency of animals in various sensory environments via the repression of the activity of a bistable switch composed of defined command interneurons. Furthermore, we show that the presentation of defined sensory modalities induces specific alterations in reversal behavior and that the AIY interneuron class mediates this alteration in locomotory behavior. We also found that the AIZ and RIB interneuron classes process odorsensory information in parallel to the AIY interneuron class. AIY, AIZ, and RIB are the first interneurons directly implicated in chemosensory signaling. Our neuronal mapping studies provide the framework for further genetic and functional dissections of neuronal circuits in C. elegans. © 2003 Wiley Periodicals, Inc. J Neurobiol 56: 178–197, 2003

Từ khóa


Tài liệu tham khảo

10.1242/dev.128.11.1951

10.1016/S0065-2911(08)60168-X

10.1242/dev.00277

Avery L, 1997, 679

10.1016/S0091-679X(08)61390-4

10.1016/0092-8674(93)80053-H

10.1016/0896-6273(91)90276-6

Bargmann CI, 1997, 717

10.1093/genetics/77.1.71

10.1152/jn.1998.80.2.762

10.1016/S0896-6273(01)00394-4

10.1523/JNEUROSCI.05-04-00956.1985

10.1523/JNEUROSCI.17-21-08259.1997

10.1016/S0065-308X(08)60319-X

Driscoll M, 1997, 645

10.1016/0092-8674(90)90493-X

10.1016/0012-1606(84)90201-X

10.1002/neu.10014

10.1073/pnas.72.10.4061

Hobert O, 1998, Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin‐11, J Neurosci, 18, 2084, 10.1523/JNEUROSCI.18-06-02084.1998

10.1016/S0896-6273(00)80944-7

Kandel ER, 1979, Cellular insights into behavior and learning, Harvey Lect, 73, 19

10.1016/S0959-4388(96)80055-9

10.1016/S0896-6273(00)81196-4

10.1002/cne.901720306

10.1152/physrev.1996.76.3.687

10.1038/376344a0

10.1038/417343a

10.1242/dev.126.9.1891

10.1523/JNEUROSCI.19-21-09557.1999

Robatzek M, 2000, Calcium/Calmodulin‐Dependent protein kinase II regulates Caenorhabditis elegans locomotion in concert with a G(o)/G(q) signaling network, Genetics, 156, 1069, 10.1093/genetics/156.3.1069

10.1523/JNEUROSCI.22-13-05727.2002

10.1101/gad.13.14.1794

10.1523/JNEUROSCI.12-06-02331.1992

10.1016/S0896-6273(01)00431-7

10.1016/S0092-8674(00)81068-5

10.1016/0092-8674(94)90028-0

10.1101/SQB.1983.048.01.049

10.1073/pnas.96.6.3257

10.1016/S0092-8674(00)80399-2

10.1242/dev.00341

10.1073/pnas.70.3.817

Weinshenker D, 1999, Block of an ether‐a‐go‐go‐like K(+) channel by imipramine rescues egl‐2 excitation defects in Caenorhabditis elegans, J Neurosci, 19, 9831, 10.1523/JNEUROSCI.19-22-09831.1999

10.1016/S0960-9822(01)00621-2

10.1098/rstb.1986.0056

10.1523/JNEUROSCI.15-03-02434.1995

10.1073/pnas.96.18.10477

10.1073/pnas.94.7.3384

10.1016/S0896-6273(00)80849-1

Thông tin
Thông tin xuất bản

Wiley

Tập 56 Số 2

178-197

Thông tin tác giả