Đặc điểm chức năng đa dạng giữa các isoform spectrin

Wiley - Tập 12 Số 4 - Trang 225-247 - 1989
Thomas R. Coleman1, Douglas J. Fishkind2, Mark S. Mooseker3, Jon S. Morrow4
1Department of Biology, Yale University, New Haven, CT 06511-8112.
2Department of Anatomy and Cellular Biology, Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston
3Department of Biology, Yale University, New Haven
4Department of Pathology, Yale University, New Haven

Tóm tắt

Tóm tắt

Mục đích của bài đánh giá này về spectrin là để xem xét các đặc tính chức năng của gia đình protein khung màng này. Các chủ đề chính bao gồm liên kết giữa spectrin và màng, liên kết giữa spectrin và sợi, vị trí của spectrin trong tế bào ở các loại tế bào khác nhau và thảo luận về sự khác biệt chức năng chính giữa spectrin thuộc dòng hồng cầu và không thuộc dòng hồng cầu. Điều này bao gồm một tóm tắt các nghiên cứu từ các phòng thí nghiệm của chúng tôi về sự so sánh chức năng và cấu trúc của các isoform spectrin ở động vật có vú, bao gồm một đơn vị alpha chung và một đơn vị beta đặc trưng cho mô. Do đó, sự khác biệt quan sát được giữa các spectrin này có thể được quy cho sự khác biệt trong các đặc tính của các đơn vị beta.

Từ khóa

#spectrin #protein khung màng #liên kết màng #đại thực bào #isoform

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